Keratan Sulfate

A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.

Also Known As:

Networked: 302 relevant articles (5 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tomatsu, Shunji: 26 articles (07/2021 - 12/2003)
2.	Orii, Tadao: 13 articles (06/2019 - 12/2003)
3.	Montaño, Adriana M: 12 articles (01/2021 - 07/2007)
4.	Kadomatsu, Kenji: 11 articles (01/2017 - 08/2006)
5.	Yamaguchi, Seiji: 9 articles (07/2021 - 12/2003)
6.	Suzuki, Yasuyuki: 9 articles (06/2019 - 04/2004)
7.	Giugliani, Roberto: 7 articles (05/2015 - 01/2004)
8.	Alméciga-Díaz, Carlos J: 6 articles (07/2020 - 09/2008)
9.	Mason, Robert W: 6 articles (06/2019 - 12/2012)
10.	Barrera, Luis A: 6 articles (01/2015 - 01/2004)

Related Diseases

1.	Mucopolysaccharidosis IV (Morquio Syndrome) 12/28/2020 - "However, no data have demonstrated improvements in bone lesions and bone grow thin MPS IVA after ERT, and there is no correlation between therapeutic efficacy and urine levels of keratan sulfate, which accumulates in MPS IVA patients. " 01/01/2017 - "Keratan sulfate (KS) is commonly elevated in urine samples from patients with mucopolysaccharidosis type IVA (MPS IVA) and is considered pathognomonic for the condition. " 01/01/2017 - "Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs." 01/01/2015 - "Keratan sulfate (KS) is a storage material in mucopolysaccharidosis IV (MPS IV). " 01/01/2013 - "Morquio A syndrome (Mucopolysaccharidosis type IVA) (MPS IVA) is a rare inherited metabolic disorder characterized by the defective degradation of keratan sulfate and chondroitin-6-sulfate. "
2.	Mucopolysaccharidoses 09/01/2013 - "Mucopolysaccharidosis IVA: correlation between genotype, phenotype and keratan sulfate levels." 04/01/2004 - "Development and testing of new screening method for keratan sulfate in mucopolysaccharidosis IVA." 01/01/2004 - "Identification of a common mutation in mucopolysaccharidosis IVA: correlation among genotype, phenotype, and keratan sulfate." 03/10/1975 - "[A new type of mucopolysaccharidosis with urinary elimination of keratan sulfate]." 09/01/2018 - "Animal studies show clearance of accumulated keratan sulfate from the body tissues in the treatment of systemic mucopolysaccharidosis by long-term enzyme replacement therapy. "
3.	Rheumatoid Arthritis 05/01/1994 - "To correlate the serum levels of keratan sulfate (KS) in patients with rheumatoid arthritis (RA) with different clinical and radiographic variables. " 05/01/1994 - "Serum keratan sulfate levels in rheumatoid arthritis: inverse correlation with radiographic staging." 06/01/1990 - "Single analyses of peripheral blood of rheumatoid arthritis (RA) patients showed a significant reduction in the mean value for keratan sulfate (KS) compared with that in control subjects, but the mean value for orosomucoid (OM) was elevated compared with that in control subjects. " 08/01/1995 - "To measure serum levels of matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-3 (MMP-3), and tissue inhibitor of MMP-1 (TIMP-1) in patients with rheumatoid arthritis (RA) and in age-matched control subjects, and to determine how these correlate with serum levels of antigenic keratan sulfate (KS) and other biochemical and clinical indicators of disease activity. " 06/01/1998 - "To determine whether patients with rheumatoid arthritis (RA) express cellular immunity to the purified G1 globular domain of cartilage proteoglycan (PG) aggrecan and whether it is influenced by the removal of keratan sulfate (KS) chains from the molecule. "
4.	Inflammation (Inflammations) 08/01/1995 - "Relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation." 10/22/2010 - "Keratan sulfate suppresses cartilage damage and ameliorates inflammation in an experimental mice arthritis model." 09/01/2005 - "By controlling the interlamellar spacing, keratan sulfate plays a role in postoperative edema, remodeling of the corneal stroma, and simultaneous regulation of inflammation after PRK." 10/01/2022 - "Over-representation analysis (% of total) revealed top up-regulated pathways at 4 and 12 weeks, respectively: Group 1, keratan sulfate metabolism (46%) and cellular processes (29%); Group 2, extracellular matrix (ECM)/collagen processes (33%) and beta oxidation (39%); Group 3, cellular processes (50%) and energy metabolism (100%); and Group 4, keratan sulfate metabolism (31%) and inflammation (50%). " 01/01/2017 - "A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models."
5.	Arthritis (Polyarthritis) 10/22/2010 - "Keratan sulfate suppresses cartilage damage and ameliorates inflammation in an experimental mice arthritis model." 09/01/2002 - "The release of 5D4 keratan sulfate epitope and serum 3B3 neoepitope was reduced in arthritis patients. " 12/01/1989 - "Using the monoclonal antibody to the keratan sulfate(KS), we modified the assay system for detecting of serum KS levels (Thonar, et al. Arthritis Rheum. " 04/15/1998 - "Susceptible BALB/c mice, however, develop arthritis only if both the chondroitin sulfate (CS) and keratan sulfate (KS) side chains of the arthritogenic human proteoglycans are removed. " 02/01/1995 - "Chondroitin 6-sulfate, an integral part of human aggrecan, was also high in OA and traumatic arthritis joint fluids, and showed a similar distribution with keratan sulfate in each disease group. "

Related Drugs and Biologics

1.	Orosomucoid (Seromucoid)
2.	Hyaluronic Acid (Hyaluronan)
3.	Proteoglycans (Proteoglycan)
4.	Glycosaminoglycans
5.	Chondroitin Sulfates (Chondroitin Sulfate)
6.	Dermatan Sulfate
7.	Heparitin Sulfate (Heparan Sulfate)
8.	Epitopes
9.	Monoclonal Antibodies
10.	Antibodies

Related Therapies and Procedures

1.	Enzyme Replacement Therapy
2.	Meniscectomy
3.	Laser In Situ Keratomileusis (LASIK)
4.	Penetrating Keratoplasty
5.	Intra-Articular Injections