Kaolin

The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: "high ridge"), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Also Known As:

Networked: 1004 relevant articles (27 outcomes, 129 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Del Bigio, Marc R: 19 articles (05/2018 - 01/2002)
2.	Neugebauer, Volker: 17 articles (11/2019 - 02/2003)
3.	Yamamoto, Kouichi: 11 articles (05/2019 - 06/2002)
4.	McAllister, James P: 10 articles (02/2022 - 06/2008)
5.	Yamatodani, Atsushi: 10 articles (05/2019 - 06/2002)
6.	Ji, Guangchen: 10 articles (12/2017 - 06/2007)
7.	da Silva Lopes, Luiza: 9 articles (01/2022 - 04/2012)
8.	Yuan, Chun-Su: 9 articles (08/2009 - 12/2003)
9.	Catalão, Carlos Henrique Rocha: 8 articles (01/2022 - 01/2012)
10.	Machado, Hélio Rubens: 7 articles (01/2022 - 11/2012)

Related Diseases

1.	Hemorrhage 01/01/2017 - "She had improvement in clinical bleeding and in kaolin thromboelastogram result and transient improvement in FXIII activity after each dose of plasma-derived FXIII concentrate (Corifact) or cryoprecipitate. " 01/01/2018 - "The objectives of this study were to investigate the correlation between thromboelastography (TEG) and conventional measures of anticoagulation, and to determine optimum values for citrated kaolin TEG R time (TEG RCK) and anti-Xa activity that would minimize both bleeding and thrombotic complications in pediatric and neonatal patients requiring extracorporeal membranous oxygenation (ECMO). " 06/01/2016 - "This study investigates the application of kaolin to control intraoperative bleeding and promote wound healing in eyelid surgery. " 01/01/2020 - "Detection of intrinsic pathway factor deficiency associated with bleeding risk by kaolin-based aPTT." 12/01/2019 - "However, the interfacial interactions between kaolinite and blood cells in hemostasis, and the effects of the stacking structure or particle size of kaolinite on bleeding control are unclear. "
2.	Hydrocephalus (Hydrocephaly) 01/01/2017 - "Histologically, there was a significant reduction in the number of cerebellar apoptotic cells after the hydrocephalus induced by kaolin (P < 0.05). " 11/08/2021 - "Kaolin induction of acquired hydrocephalus in juvenile pigs produced an in vivo model that is highly translational, allowing systematic studies of the pathophysiology and clinical treatment of hydrocephalus." 01/01/2021 - "Neurobehavioural changes and morphological study of cerebellar purkinje cells in kaolin induced hydrocephalus." 01/01/2019 - "The aim of the present study is to compare which method of Kaolin injection into fetal cisterna magna is feasible, safer, and more effective to induce hydrocephalus in fetal lambs. " 07/01/2017 - "This study reported degenerative changes of oligodendrocytes and its organelles in kaolin-induced hydrocephalus. "
3.	Vomiting 08/01/2015 - "We aimed to establish a rodent model of delayed emesis and explore EA effects on kaolin intake. " 10/30/2004 - "Conversely, all treatments induced kaolin consumption in rats without inducing emesis. " 12/06/2022 - "The results of the included studies were subdivided into four categories: kaolin consumption, retching and vomiting, food intake, and weight loss. " 04/01/2016 - "Kaolin intake, food intake and bodyweight change were evaluated as markers of nausea and vomiting severity. " 01/01/2013 - "The use of a mouse pica model, based on the consumption of kaolin, was also evaluated as a possible surrogate for studying emesis but was found unsuitable. "
4.	Hyperalgesia 04/01/2008 - "The combination of SCI and subarachnoid kaolin injection resulted in a significantly greater syrinx formation and perilesional myelomalacia than SCI alone; SCI and kaolin injection significantly attenuated locomotor recovery and exacerbated neuropathic pain (mechanical allodynia) compared with SCI alone. " 07/19/2007 - "Modifications in temperature, body weight gain, food and kaolin intake, and the threshold for mechanical allodynia were recorded. " 05/01/1998 - "The present study investigated whether spinal administration of S-(+)-3-isobutylgaba (S-(+)-3-IBG) or its stereoisomer, R-(-)-3-isobutylgaba (R-(-)-3-IBG), are effective in reducing the hyperalgesia and swelling observed after injection of kaolin and carrageenan into the knee joint of the rat. " 04/01/2018 - "The ED50 in this model was 6.6 mg/kg. Flunixin exhibited marked antinociceptive effect on kaolin-induced inflammatory hyperalgesia in piglets." 12/24/2008 - "The spinal GLT-1 gene transfer had no effect on acute mechanical and thermal nociceptive responses in naive rats, whereas it significantly reduced the inflammatory mechanical hyperalgesia induced by hindlimb intraplantar injection of carrageenan/kaolin. "
5.	Body Weight (Weight, Body) 01/01/2022 - "The intake of kaolin and chow diet as well as body weights were recorded every 24 hours. " 04/20/2009 - "However, those with access to kaolin ate more food and lost less body weight than did those without access to kaolin. " 07/01/2005 - "Kaolin intake, food intake, and body weight were measured every 24 h for 120 h. " 08/01/1986 - "These results indicate that SCFA accelerates epithelial cell proliferation, thereby increasing cecal tissue weight, kaolin stimulates body weight gain which is accompanied by a proportional increase in the tissue weight of some digestive organs, and the actions of these factors are independent of each other." 08/01/1986 - "Kaolin increased the tissue weight, but not relative tissue weight (tissue weight/empty body weight), of the forestomach, distal colon, liver and heart by 6-14%. "

Related Drugs and Biologics

1.	Hemostatics (Antihemorrhagics)
2.	Cisplatin (Platino)
3.	Chitosan
4.	Clay
5.	Bentonite (Montmorillonite)
6.	Carrageenan
7.	Dextrans (Dextran)
8.	Factor VIII (Coagulation Factor VIII)
9.	Anticoagulants
10.	Melatonin

Related Therapies and Procedures

1.	Therapeutics
2.	Debridement
3.	Catheters
4.	Injections
5.	Transcutaneous Electric Nerve Stimulation (TENS)