Joint Instability (Joint Laxity)

Lack of stability of a joint or joint prosthesis. Factors involved are intra-articular disease and integrity of extra-articular structures such as joint capsule, ligaments, and muscles.

Also Known As:

Networked: 345 relevant articles (5 outcomes, 33 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Rupture
2.	Pain (Aches)
3.	Osteoarthritis
4.	Congenital Abnormalities (Deformity)
5.	Pelvic Organ Prolapse

Experts

1.	Birk, David E: 4 articles (06/2015 - 09/2002)
2.	Soslowsky, Louis J: 3 articles (06/2015 - 06/2011)
3.	Voermans, N C: 3 articles (03/2015 - 01/2009)
4.	De Paepe, Anne: 3 articles (12/2014 - 10/2012)
5.	Malfait, Fransiska: 3 articles (12/2014 - 10/2012)
6.	Hastings, Mary K: 3 articles (11/2014 - 09/2011)
7.	Johnson, Jeffrey E: 3 articles (11/2014 - 09/2011)
8.	Sinacore, David R: 3 articles (11/2014 - 09/2011)
9.	Rosenwasser, Melvin P: 3 articles (06/2014 - 09/2003)
10.	Wolf, Jennifer Moriatis: 3 articles (04/2014 - 02/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Joint Instability:

1.	Carbon MonoxideIBA 09/01/2004 - "The OA group showed significantly greater knee instability (P = 0.002), medial joint laxity (P = 0.001), greater medial quadriceps-medial gastrocnemius (VMMG) co-contraction (P = 0.043), and greater knee adduction moments (P = 0.019) than the control group. " 09/01/2001 - "It was found that the subjects were capable of generating net abduction and adduction moment through differential co-contraction of muscles crossing the medial and lateral sides of the knee, which helped to reduce the abduction-adduction joint laxity (p< or =0.01) and increase stiffness (p<0.027) and viscous damping. " 08/01/2013 - "Interpretation Individuals with KOA exhibited increased co-contraction, amplitude and duration of lateral knee muscles regardless of disease severity, limb alignment or medial joint laxity. " 05/01/2007 - "These changes produced a diminution of co-contraction during single limb support for both the amputated and non-amputated limbs and, thus, could create joint instability." 04/01/2006 - "We used families of Boykin spaniels (BSs) to determine the level of joint laxity in the breed and to conduct an initial whole-genome screening to identify markers that co-segregate with increased joint laxity. "
2.	Estradiol (Estrace)FDA LinkGeneric 09/01/2005 - "Knee and ankle joint laxities are greater for women compared to men; however, the cyclic estradiol and progesterone fluctuations that occur during the menstrual cycle do not produce cyclic fluctuations of joint laxity. " 09/01/2005 - "Little is known about whether joint laxity varies cyclically during the menstrual cycle and if so, whether it is modulated by cyclic variations of estradiol (E2) and progesterone (P4). " 12/01/2015 - "The testing of generalized joint laxity was performed with the aid of the "laxity score" according to Beighton et al. Subjects with ACL rupture have highly statistically significantly greater concentrations of testosterone (p < 0.01), statistically significantly greater concentrations of 17-β estradiol (p < 0.05), and a highly statistically significantly greater generalized joint laxity score than subjects with an intact ACL (p < 0.01). " 02/01/2003 - "Fifty-seven percent of women developed subjective joint pain during pregnancy, which was not associated with increased joint laxity, but was associated with significantly increased levels of estradiol and progesterone. " 02/01/2003 - "Peripheral joint laxity increases during pregnancy; however, these changes do not correlate well with maternal estradiol, progesterone, or relaxin levels."
3.	Testosterone (Sustanon)FDA Link 12/01/2015 - "The testing of generalized joint laxity was performed with the aid of the "laxity score" according to Beighton et al. Subjects with ACL rupture have highly statistically significantly greater concentrations of testosterone (p < 0.01), statistically significantly greater concentrations of 17-β estradiol (p < 0.05), and a highly statistically significantly greater generalized joint laxity score than subjects with an intact ACL (p < 0.01). " 12/01/2015 - "The purpose of this study is to determine the difference in the concentrations of testosterone, 17-β estradiol and progesterone between male patients with and without ACL rupture, as well as the possible effect of these hormones on generalized joint laxity. " 09/01/2015 - "The purpose of this study was to determine the difference in the concentrations of testosterone, 17-β estradiol and progesterone between female patients with and without ACL rupture and the possible effect of these hormones on generalised joint laxity. "
4.	Glucose (Dextrose)FDA LinkGeneric 03/01/2000 - "However, Hotelling multivariate analysis of paired values at 0 and 12 months for pain, swelling, joint flexion, and joint laxity in the dextrose-treated knees, revealed a statistically significant improvement (P = .021). "
5.	CollagenIBA 06/01/2015 - "This study provides evidence that the regulatory role of collagen V in extracellular matrix assembly is tissue dependent and that joint instability in classic EDS may be caused in part by insufficient mechanical properties of the tendons and ligaments surrounding each joint." 05/15/1997 - "This paper summarizes some of the studies that investigated the relationship between joint laxity and a defect in collagen metabolism and the influence that alterations in transsynovial flow have on joint laxity." 06/01/2015 - "Emotion processing in joint hypermobility: A potential link to the neural bases of anxiety and related somatic symptoms in collagen anomalies." 01/01/2015 - "One common constitutional difference is Joint Hypermobility, in which there is an increased range of joint movement as a result of a variant of collagen. " 01/01/2014 - "Joint hypermobility, an expression of a common variation in the connective tissue protein collagen, is increasingly recognized as a risk factor to anxiety and related disorders. "
6.	RelaxinIBA 01/01/2015 - "In this study, we investigated the activity of serum relaxin in female patients with benign joint hypermobility syndrome (BJHS), locomotor system findings accompanying BJHS, and its relation to relaxin. " 04/01/2013 - "The purpose of this study was to evaluate the correlation of serum relaxin with radiographic laxity at the trapezial-metacarpal joint and with generalized joint laxity. " 06/01/2002 - "Gravidity studies have intimated a relationship between serum relaxin levels and joint laxity. " 04/01/2013 - "However, we were unable to show a direct link between serum relaxin and generalized joint laxity. " 04/01/2013 - "In a large volunteer population, we demonstrated a relationship between circulating relaxin and trapezial-metacarpal joint laxity. "
7.	HormonesIBA 09/01/2005 - "Although the mechanism by which these factors combine to increase injury risk is unclear, studies suggest that cyclic variations in joint laxity produced by hormone fluctuation during the menstrual cycle predispose an athlete to increased risk of ligamentous injury. " 09/01/2015 - "The concentrations of these hormones do not affect generalised joint laxity. " 02/01/2003 - "Characterization of the relationship between joint laxity and maternal hormones in pregnancy." 09/01/2015 - "Additional research on a larger group of patients is necessary to further determine the effects of these hormones on generalised joint laxity and ACL ruptures. " 03/01/2000 - "Speculation on the possible etiology of anterior cruciate ligament injuries in women has centered on anatomic differences, joint laxity, hormones, and training techniques. "
8.	proline dipeptidase (prolidase)IBA 01/01/2014 - "This study was carried out to determine the serum prolidase activity in female patients with benign joint hypermobility syndrome (BJHS), and to evaluate its correlation with their clinical features. " 01/01/2014 - "The prolidase activity, total oxidant status, and oxidative stress index were higher in tissue samples from patients with joint hypermobility (p < 0.001). " 01/01/2014 - "Serum prolidase activity in benign joint hypermobility syndrome." 01/01/2014 - "The aim of this study was to evaluate whether joint hypermobility is involved in the development of inguinal hernia in children and to investigate oxidative stress parameters and prolidase activity in tissue samples from children with inguinal hernia. " 01/01/2014 - "Evaluation of antioxidative/oxidative status and prolidase parameters in cases of inguinal hernia with joint hypermobility syndrome."
9.	ProgesteroneFDA LinkGeneric 09/01/2005 - "Knee and ankle joint laxities are greater for women compared to men; however, the cyclic estradiol and progesterone fluctuations that occur during the menstrual cycle do not produce cyclic fluctuations of joint laxity. " 09/01/2005 - "Little is known about whether joint laxity varies cyclically during the menstrual cycle and if so, whether it is modulated by cyclic variations of estradiol (E2) and progesterone (P4). " 02/01/2003 - "Fifty-seven percent of women developed subjective joint pain during pregnancy, which was not associated with increased joint laxity, but was associated with significantly increased levels of estradiol and progesterone. " 02/01/2003 - "Peripheral joint laxity increases during pregnancy; however, these changes do not correlate well with maternal estradiol, progesterone, or relaxin levels." 02/01/2003 - "To evaluate peripheral joint laxity during pregnancy and to correlate changes with serum cortisol, estradiol, progesterone, and relaxin. "
10.	Polyethylene (Polythene)IBA 01/01/2003 - "The aim of this study was to investigate the influence of joint laxity and microseparation on the wear of ceramic on polyethylene artificial hip joints in an in vitro simulator. " 10/01/2013 - "Radiological evaluation revealed no loosening of the implant after 5 years except in one patient who required revision due to polythene wear with secondary joint instability. " 08/01/2014 - "Main complications of the reverse shoulder prosthesis are due to the joint instability, the scapular notching and the wear of the polyethylene insert. " 04/19/2010 - "Effect of joint laxity on polyethylene wear in total knee replacement." 01/01/2003 - "Wear and deformation of ceramic-on-polyethylene total hip replacements with joint laxity and swing phase microseparation."

Therapies and Procedures

1.	Hip Replacement Arthroplasty (Total Hip Replacement) 09/01/2004 - "[Experimental analysis of neutral, asymmetric and constraint liners for total hip replacement: investigation of range of motion and protection against joint instability]." 01/01/2009 - "Osteonecrosis of the femoral head is the endpoint of a disease process that results from insufficient blood flow and bone-tissue necrosis, leading to joint instability, collapse of the femoral head, arthritis of the joint, and total hip replacement. " 01/01/2003 - "Wear and deformation of ceramic-on-polyethylene total hip replacements with joint laxity and swing phase microseparation."
2.	Arthroplasty 12/01/2011 - "The purposes of this study were to determine the contributions of each shoulder muscle to glenohumeral joint force during abduction and flexion in both the anatomical and post-operative shoulder and to identify factors that may contribute to the incidence of glenoid component loosening/failure and joint instability in the shoulder after reverse shoulder arthroplasty (RSA). " 10/01/2009 - "Analysis of joint laxity after total ankle arthroplasty: cadaver study." 01/01/2005 - "A series of studies have been performed to examine the intrinsic constraint of various total elbow arthroplasty designs, as well as the joint laxity after implantation in cadaveric specimens." 07/01/2015 - "Nevertheless, joint laxity and aseptic effusion, along with a progressive chondrolysis, lead to early BFOA failure in six patients, which were revised by total knee arthroplasty at 19.5 ± 3.9 months follow-up. " 03/01/2014 - "Relative risk of impingement and joint instability during sexual activities after total hip arthroplasty (THA) has never been objectively investigated. "
3.	Arthrodesis 02/01/2015 - "The fanning technique of arthrodesis of the CMC joint may lead to fracture of carpal bones, joint instability, and MC joint subluxation. " 02/01/2012 - "In cases of joint instability or arthrosis, arthrodesis of the thumb and index finger MP or IP joints, alone or in combination, may be indicated." 06/01/2014 - "Our study results indicate the technique promotes rapid union at a precise angle, provides strong fixation that does not require prolonged immobilization, does not cause hardware irritation, and can be used in conjunction with other procedures including TMC arthroplasty when MCP arthrodesis is indicated for joint instability." 11/01/1988 - "This study evaluates an arthrodesis technique that can be used for digital joint instability or deformity in skeletally immature patients. " 01/01/1999 - "The management options of this joint instability, complicated with secondary arthritis, have rarely been discussed and consist mainly of fibular head resection or arthrodesis of this joint. "
4.	Transplants (Transplant) 04/01/2008 - "The purpose of the present study was to compare the clinical results of anterior cruciate ligament reconstruction with use of different grafts in patients with or without excessive joint laxity. " 09/01/2015 - "To ascertain whether differences exist in joint instability after experimentally induced failure of medial patellofemoral ligament (MPFL) reconstruction in the cadaver knee with the four graft types most widely used for this procedure, and whether any of these grafts are associated with decreased risk in the event of failure. " 06/01/2014 - "Acute und chronic acromioclavicular joint separations type Rockwood III-VI. Recurrent AC-joint instability with intact coracoid process (with tendon graft). " 12/01/2013 - "The biological graft afforded better clinical and radiographic outcomes than the synthetic ligament in patients with chronic AC joint instability. " 01/01/2013 - "Larger grafts were associated with lower meniscal stress, decreased joint laxity, and less articular cartilage contact stress. "
5.	Osteotomy 03/01/2006 - "The purpose of this study was to measure the laxity of cadaveric thumb CMC joints and to determine the influence of ligament reconstruction and metacarpal osteotomy on joint laxity and contact area. " 06/01/2014 - "Dorsoradial ligament imbrication is a direct and effective alternative to ligament reconstruction or metacarpal osteotomy in patients with symptomatic thumb carpometacarpal (CMC) joint instability. " 01/01/2014 - "The principle of the different tibial osteotomies is the muscular compensation of stifle joint instability. " 06/01/2012 - "Because osseous abnormalities result in distal radioulnar joint instability, a sigmoid notch osteotomy is used to restore stability. " 08/01/2009 - "A combination of the medial displacement calcaneal osteotomy with the Evans lateral column-lengthening osteotomy has been suggested when hindfoot valgus, forefoot abduction, and midtarsal joint instability are significant. "