Neonatal Jaundice

Yellow discoloration of the SKIN; MUCOUS MEMBRANE; and SCLERA in the NEWBORN. It is a sign of NEONATAL HYPERBILIRUBINEMIA. Most cases are transient self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) occurring in the first week of life, but some can be a sign of pathological disorders, particularly LIVER DISEASES.

Also Known As:

Networked: 732 relevant articles (30 outcomes, 78 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Glucosephosphate Dehydrogenase Deficiency
2.	Infertility (Sterility)
3.	Hemorrhage
4.	Toxemia
5.	Rubella (German Measles)

Experts

1.	Stevenson, David K: 9 articles (01/2014 - 10/2002)
2.	Wong, Ronald J: 8 articles (01/2014 - 10/2002)
3.	Hansen, Thor Willy Ruud: 7 articles (07/2015 - 01/2002)
4.	Vreman, Hendrik J: 7 articles (01/2014 - 10/2002)
5.	Hansen, T W: 5 articles (11/2001 - 07/2000)
6.	Bhutani, Vinod K: 4 articles (07/2013 - 10/2008)
7.	Ahlfors, Charles E: 4 articles (01/2013 - 10/2004)
8.	Qadir, Maqbool: 3 articles (09/2015 - 05/2012)
9.	Brites, Dora: 3 articles (11/2014 - 12/2006)
10.	Tiribelli, Claudio: 3 articles (03/2014 - 06/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neonatal Jaundice:

1.	BilirubinIBA 09/01/2013 - "amarus may be beneficial in reducing bilirubin level as well as oxidative stress in neonatal jaundice." 06/01/2010 - "Information on the level of bilirubin production and its rate of elimination may help to guide the clinical management of neonatal jaundice." 01/01/2015 - "Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice." 11/01/2014 - "Accordingly, recent studies revealed vascular dysfunction in neonatal jaundice, a common pathology in the early neonatal period affecting 1/10 children presenting values of total bilirubin>17 mg/dL (291 μM). " 01/01/2014 - "Our study examined the accuracy of transcutaneous bilirubin measurements in clinically jaundiced healthy-term Greek newborns, using total serum bilirubin as the reference standard, in order to re-evaluate our local guidelines about neonatal jaundice. "
2.	tin protoporphyrin IXIBA 06/01/1992 - "However, if it can be shown that tin-protoporphyrin can serve as a safe and less costly alternate treatment, a considerable improvement in the management of neonatal jaundice would be achieved." 01/01/1990 - "However, if it can be shown that the use of tin-protoporphyrin can serve as a safe and less costly alternate treatment, a considerable improvement in the management of neonatal jaundice will be achieved." 09/01/1987 - "Tin-protoporphyrin and neonatal jaundice." 09/24/1982 - "Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model." 02/01/1993 - "The heme oxygenase inhibitor, tin protoporphyrin, is being studied for the prevention of neonatal jaundice. "
3.	ClofibrateFDA Link 02/01/2005 - "Therefore, clofibrate is now the only available pharmacological treatment of neonatal jaundice." 11/01/1998 - "Therefore clofibrate represents the only pharmacological treatment of neonatal jaundice actually available." 12/01/1991 - "Clofibrate treatment of neonatal jaundice." 10/01/1990 - "Clofibrate treatment of neonatal jaundice." 01/01/2012 - "In conclusion, clofibrate was effective in reducing neonatal jaundice and its effect appeared 24 hours after treatment."
4.	MetalloporphyrinsIBA 04/01/2005 - "Since the 1980s and 1990s, there have been no publications on trials to determine the efficacy of metalloporphyrins in the treatment of neonatal jaundice. " 04/01/2005 - "Metalloporphyrins for the treatment of neonatal jaundice." 10/01/2002 - "Metalloporphyrins (Mps) have been well characterized as competitive inhibitors of HO and have been evaluated as potential chemopreventive agents for neonatal jaundice. " 12/01/2001 - "Alternative metalloporphyrins for the treatment of neonatal jaundice." 08/01/2000 - "Certain metalloporphyrins such as SnPP are being tested as drugs for the treatment of neonatal jaundice. "
5.	Vitamin EFDA LinkGeneric 08/21/1980 - "Controlled clinical trials of vitamin E supplementation may be warranted to examine its efficacy in ameliorating acute hemolytic crises or in reducing morbidity from neonatal jaundice in this relatively common genetic disorder." 10/01/1999 - "Vitamin E is also useful for the treatment of toxemia of pregnancy, intra-uterine growth retardation (IUGR), and neonatal jaundice. " 04/01/1993 - "The therapeutic use of vitamin E was reviewed, and it was concluded that there was a large number of diseases for example, sterility, toxemia of pregnancy, IUGR, neonatal jaundice, climacteric syndrome, in which a therapeutic value for vitamin E could be clearly establish, vitamin K prophylaxis is also under taken for the neonate. "
6.	Intravenous Immunoglobulins (IVIG)FDA Link 06/01/2011 - "We conducted a study to compare single versus multiple dose of IVIG in combination with light emitting diode (LED) phototherapy in patients with neonatal jaundice secondary to ABO blood incompatibility, and compared the efficacy of these treatments with that in a group of patients who received LED phototherapy solely. " 06/01/2011 - "Intravenous immunoglobulin (IVIG) has been found to decrease hemolysis in neonatal jaundice due to blood group incompatibility, but a consensus on its usage has not been reached. "
7.	tin mesoporphyrinIBA 04/01/2005 - "Recent case reports and previous evidence from larger clinical trials conducted in Greece and Argentina in the 1980s and 1990s demonstrate that tin mesoporphyrin is useful in the treatment of neonatal jaundice. "
8.	PorphyrinsIBA 01/01/1993 - "In the first reported comparison of chromium porphyrin efficacy in vivo, our data suggest that chromium porphyrins, and particularly CrMP, may be effective in chemopreventive strategies for the treatment of neonatal jaundice." 10/01/1988 - "Purple versus yellow: preventing neonatal jaundice with tin-porphyrins." 11/01/2009 - "In addition, the results of inhibiting ring opening reaction of tin verdoheme complexes could support the great interest of tin porphyrin analogues as pharmacologic means of chemoprevention of neonatal jaundice by the competitive inhibitory action of tin porphyrins on heme oxygenase."
9.	Nifedipine (Adalat)FDA LinkGeneric 04/01/2000 - "Logistic regression analysis showed that even after correction for gestational age at birth, newborn risk of RDS, intracranial bleeding, or neonatal jaundice was significantly lower in the nifedipine group than the ritodrine group. " 02/01/2011 - "Nifedipine was associated with a significant reduction in the risk of delivery within 7 days of initiation of treatment and before 34 weeks' gestation, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, neonatal jaundice, and admission to the neonatal intensive care unit when compared with β₂-adrenergic-receptor agonists. "
10.	Metformin (Glucophage)FDA LinkGeneric 08/01/2009 - "Neonatal morbidity was improved in the metformin group; prematurity (0 vs. 10%, P < 0.01), neonatal jaundice (8 vs. 30%, P < 0.01) and admission to neonatal unit (6 vs. 19%, P < 0.01). " 04/01/1979 - "Apart from a high incidence of neonatal jaundice requiring phototherapy the infant morbidity in the Metformin group was low. "

Therapies and Procedures

1.	Phototherapy (Light Therapy) 03/01/2014 - "Both spectra exhibit maxima near 476 nm and widths at half height of about 50 nm. This result supports the conclusion that light between 460 and 490 nm is most effective for phototherapy of neonatal jaundice." 11/01/2006 - "Hanging white curtains around phototherapy units significantly increases efficacy of phototherapy in the treatment of neonatal jaundice without evidence of increased adverse effects." 01/01/1992 - "The efficacy of 'standard' daylight phototherapy and 'high intensity' blue light phototherapy for neonatal jaundice from ABO-HD, or of a non-haemolytic nature was evaluated. " 05/01/2010 - "Overhead is superior to underneath light-emitting diode phototherapy in the treatment of neonatal jaundice: a comparative study." 07/01/2015 - "Phototherapy using blue light-emitting diodes (LED) is effective against neonatal jaundice. "
2.	Neonatal Intensive Care 11/01/2015 - "Neonatal complications, such as respiratory distress syndrome (RDS), neonatal hypoglycaemia, neonatal jaundice and subsequent admission to a neonatal intensive care unit (NICU) were significantly higher for neonates born to mothers with PGDM compared to those born to mothers with GDM (P <0.001). " 01/01/1997 - "The influence of several clinical factors on the cephalocaudal progression of neonatal jaundice was investigated in 377 newborns admitted to the neonatal intensive care unit for various reasons. " 12/01/2012 - "Findings indicated that neonatal jaundice, exposure to human immunodeficiency virus (HIV), mechanical or assisted ventilation, and neonatal intensive care unit stay greater than 48 hours were the most frequently occurring high-risk factors for hearing loss in the current sample. " 12/07/2015 - "This study involved 65 critically ill full-term and preterm newborns admitted to the neonatal intensive care unit (NICU), divided into three groups: 25 newborns with bacterial neonatal sepsis (group A); 15 newborns with a diagnosis of non-bacterial SIRS and with no localizing source of bacterial infection (group B); and 25 babies with no clinical or bacteriological signs of systemic or local infection receiving routine NICU care, most of them treated with phototherapy for neonatal jaundice (group C). " 01/01/2014 - "Calcium channel blockers resulted in an increase in the interval between trial entry and birth (average MD 4.38 days, 95% CI 0.25 to 8.52) and gestational age (MD 0.71 weeks, 95% CI 0.34 to 1.09), while decreasing preterm and very preterm birth (RR 0.89, 95% CI 0.80 to 0.98 and RR 0.78, 95% CI 0.66 to 0.93); respiratory distress syndrome (RR 0.64, 95% CI 0.48 to 0.86); necrotising enterocolitis (RR 0.21, 95% CI 0.05 to 0.96); intraventricular haemorrhage (RR 0.53, 95% CI 0.34 to 0.84); neonatal jaundice (RR 0.72, 95% CI 0.57 to 0.92); and admissions to neonatal intensive care unit (NICU) (average RR 0.74, 95% CI 0.63 to 0.87). "
3.	Massage (Reflexology) 01/01/2011 - "We suggest baby massage is beneficial for ameliorating neonatal jaundice." 01/01/2011 - "Baby massage ameliorates neonatal jaundice in full-term newborn infants." 01/01/2011 - "In the present study, the effects of gentle baby massage on neonatal jaundice in full term newborn infants were evaluated by a controlled clinical trial. " 06/01/2015 - "The effect of massage on neonatal jaundice in stable preterm newborn infants: a randomized controlled trial." 01/01/2011 - "Newborn massage and neonatal jaundice."
4.	Hemoperfusion 01/01/1977 - "These studies suggest that AAG hemoperfusion is effective in the treatment of neonatal jaundice, although potential problems such as sterility and platelet loss need further evaluation before it can be considered for human use." 01/01/1977 - "Hemoperfusion through albumin-conjugated agarose gel for the treatment of neonatal jaundice in premature rhesus monkeys."
5.	Aftercare (After-Treatment) 09/01/2007 - "People, usually males, with deficient alleles are susceptible to neonatal jaundice, and acute hemolytic anemia, usually during infection, after treatment with certain drugs or after eating fava beans. " 01/01/2012 - "In conclusion, clofibrate was effective in reducing neonatal jaundice and its effect appeared 24 hours after treatment." 05/01/1993 - "Auditory evoked responses using BERA were studied in 30 newborn babies with plasma bilirubin > or = 15 mgm/dl and repeated after treatment of neonatal jaundice with bilirubin levels of < or = 10 mgm/dl. "