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Chronic Idiopathic Jaundice (Dubin Johnson Syndrome)

A benign, autosomally recessive inherited hyperbilirubinemia characterized by the presence of a dark pigment in the centrilobular region of the liver cells. There is a functional defect in biliary excretion of bilirubin, cholephilic dyes, and porphyrins. Affected persons may be asymptomatic or have vague constitutional or gastrointestinal symptoms. The liver may be slightly enlarged, and oral and intravenous cholangiography fails to visualize the biliary tract.
Also Known As:
Dubin Johnson Syndrome; Syndrome, Dubin-Johnson; Jaundice, Chronic Idiopathic; Hyperbilirubinemia 2; Hyperbilirubinemia II; Chronic Idiopathic Jaundices; Hyperbilirubinemia 2s; Hyperbilirubinemia IIs; Idiopathic Jaundice, Chronic; Idiopathic Jaundices, Chronic; Jaundices, Chronic Idiopathic; Dubin-Johnson Syndrome
Networked: 184 relevant articles (7 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Jaundice (Icterus)
2. Gilbert Disease
3. Hereditary Hyperbilirubinemia (Rotor Syndrome)
4. Liver Diseases (Liver Disease)
5. Hepatocellular Carcinoma (Hepatoma)

Experts

1. Hayashi, Hisao: 5 articles (10/2007 - 01/2003)
2. Wakusawa, Shinya: 5 articles (10/2007 - 01/2003)
3. Keppler, Dietrich: 4 articles (01/2011 - 07/2002)
4. Yano, Motoyoshi: 4 articles (10/2007 - 01/2003)
5. Machida, Ikuo: 4 articles (04/2005 - 01/2003)
6. Jirsa, Milan: 3 articles (02/2013 - 07/2005)
7. Suzuki, Satoshi: 3 articles (10/2004 - 01/2003)
8. Keitel, Verena: 2 articles (01/2021 - 01/2003)
9. Huang, Jian: 2 articles (01/2020 - 11/2018)
10. Jia, Jidong: 2 articles (01/2020 - 11/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Idiopathic Jaundice:
1. Bile Acids and Salts (Bile Acids)IBA
2. Phenobarbital (Luminal)FDA Link
3. Ursodeoxycholic Acid (Urso)FDA LinkGeneric
4. Technetium Tc 99m LidofeninIBA
5. IronIBA
6. Rose BengalIBA
7. Glycocholic AcidIBA
8. BilirubinIBA
9. Adenosine Triphosphate (ATP)IBA
10. Multidrug Resistance-Associated Protein 2IBA

Therapies and Procedures

1. Therapeutics
2. Segmental Mastectomy (Lumpectomy)
3. Lasers (Laser)
4. Aftercare (After-Treatment)
5. Hepatectomy