Isoxsuprine

A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.

Also Known As:

Networked: 102 relevant articles (4 outcomes, 12 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Alavi, Azin: 1 article (08/2015)
2.	Faghihi, Armaghan: 1 article (08/2015)
3.	Rajaee, Minoo: 1 article (08/2015)
4.	Amirian, Malihe: 1 article (08/2015)
5.	Jahanshahi, Keramat Allah: 1 article (08/2015)
6.	Mahboobi, Hamidreza: 1 article (08/2015)
7.	Silva, Alcino Lázaro da: 1 article (07/2015)
8.	Vidigal, Paula Vieira Teixeira: 1 article (07/2015)
9.	Costa, Walder: 1 article (07/2015)
10.	Costa, Gustavo Rocha: 1 article (07/2015)

Related Diseases

1.	Premature Obstetric Labor (Premature Labor) 08/01/2015 - "Effect of Maintenance Therapy with Isoxsuprine in the Prevention of Preterm Labor: Randomized controlled trial." 09/01/1981 - "Seventy patients treated with isoxsuprine for premature labor were studied. " 09/01/1981 - "Risk:benefit considerations for the use of isoxsuprine in the treatment of premature labor." 10/01/1980 - "The treatment of premature labor with isoxsuprine." 03/01/1979 - "A retrospective study of all inborn infants at 26 to 35 weeks' gestational age delivered from August, 1976, through July, 1977, was undertaken to determine the effects on the neonate of maternal isoxsuprine therapy for premature labor. "
2.	Stroke (Strokes) 01/01/2014 - "Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening." 01/01/2014 - "Isoxsuprine, a β2-adrenergic agonist and NR2B subtype-selective N-methyl-D-aspartate (NMDA) receptor antagonist, demonstrated no loss of efficacy when administered up to an hour after reoxygenation in an in vitro stroke model. " 01/01/2014 - "Our demonstration of the significant and novel neuroprotective action of isoxsuprine hydrochloride in an in vivo stroke model and its history of human use suggest that isoxsuprine may be an ideal candidate for further investigation as a potential stroke therapeutic."
3.	Retinal Artery Occlusion 05/05/1968 - "Successful remission of central retinal artery occlusion following the use of isoxsuprine."
4.	Erectile Dysfunction 07/01/2001 - "Isoxsuprine is no better than placebo as a first-line treatment for mixed-type erectile dysfunction." 07/01/2001 - "To determine the effectiveness and safety of high-dose isoxsuprine for the treatment of mixed-type erectile dysfunction. " 07/01/2001 - "Therapeutic effects of high-dose isoxsuprine in the management of mixed-type impotence."
5.	Necrosis 10/01/1981 - "In a controlled study of the rat abdominal pedicle flap the area of flap necrosis was not reduced by a course of treatment with isoxsuprine. " 07/01/1980 - "A study of the treatment time necessary for the vasodilator drug isoxsuprine to prevent necrosis in a skin flap." 07/01/2015 - "In the macroscopic evaluation of isoxsuprine Group retail presented absolute numbers: final area (p=0.001*) and viable area (p=0.006*) with the highest values; necrosis (p=0.001*) had the lowest value. " 10/01/1979 - "Prevention of necrosis in island myocutaneous flaps in the pig by treatment with isoxsuprine." 06/01/1979 - "The results imply that necrosis of skeletal muscle in a clinical flap could be prevented by treatment with isoxsuprine."

Related Drugs and Biologics

1.	Ritodrine (Yutopar)
2.	N-Methylaspartate (NMDA)
3.	Isoxsuprine
4.	Glucose (Dextrose)
5.	Dexamethasone (Maxidex)
6.	Nicotine
7.	Hyaluronoglucosaminidase (Hyaluronidase)
8.	Caffeine (No Doz)
9.	Acetaminophen (Paracetamol)
10.	Terbutaline (Brethaire)

Related Therapies and Procedures

1.	Tocolysis
2.	Injections
3.	Intrauterine Devices (Intrauterine Device)
4.	Drug Therapy (Chemotherapy)
5.	Cesarean Section (Caesarean Section)