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Isoproterenol (Isoprenaline)

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Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.

Also Known As:

Isoprenaline; Isuprel; Norisodrine; 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol; Euspiran; Isadrin; Isadrine; Isopropyl Noradrenaline; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol Hydrochloride; Isoproterenol Sulfate; Izadrin; Novodrin; Hydrochloride, Isoproterenol; Noradrenaline, Isopropyl; Sulfate, Isoproterenol; Isopropylarterenol; 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-

Networked: 4681 relevant articles (204 outcomes, 543 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Catecholamines: 6143
    - Isoproterenol: 4681
  - Amino Alcohols: 14
    - Ethanolamines: 12
      - Isoproterenol: 4681
        dichloroisoproterenol: 10
        hydroxybenzylisoproterenol: 5
        clorprenaline: 4
        1-phenyl-2-isopropylaminoethanol
        2-(3,4-diacetoxyphenyl)-2-chloro-N-isopropyl-1-ethanamine
        3-O,4-O-diacetylisoproterenol
        3-O,4-O-dibenzoylisoproterenol
        4-chloroisoprenaline
        di-4-toluoylisoproterenol
        dipivaloylisoproterenol
        isolevin
        metiprenaline
- Alcohols: 387
  - Amino Alcohols: 14
    - Ethanolamines: 12
      - Isoproterenol: 4681
        dichloroisoproterenol: 10
        hydroxybenzylisoproterenol: 5
        clorprenaline: 4
        1-phenyl-2-isopropylaminoethanol
        2-(3,4-diacetoxyphenyl)-2-chloro-N-isopropyl-1-ethanamine
        3-O,4-O-diacetylisoproterenol
        3-O,4-O-dibenzoylisoproterenol
        4-chloroisoprenaline
        di-4-toluoylisoproterenol
        dipivaloylisoproterenol
        isolevin
        metiprenaline

Experts

1.	Stanely Mainzen Prince, P: 19 articles (04/2015 - 01/2006)
2.	Arya, Dharamvir Singh: 15 articles (01/2015 - 04/2004)
3.	Kumari, Santosh: 13 articles (01/2015 - 03/2007)
4.	Brembilla-Perrot, B: 12 articles (08/2010 - 12/2000)
5.	Prince, P Stanely Mainzen: 10 articles (02/2015 - 10/2005)
6.	Garjani, Alireza: 10 articles (01/2015 - 09/2011)
7.	Brembilla-Perrot, Béatrice: 9 articles (11/2015 - 08/2003)
8.	Beurrier, Daniel: 8 articles (11/2015 - 08/2003)
9.	Ojha, Shreesh: 8 articles (01/2015 - 11/2010)
10.	Soraya, Hamid: 8 articles (01/2015 - 09/2011)

Related Diseases

1.	Myocardial Infarction 01/01/2014 - "vulgare extract has strong protective effects against isoproterenol-induced myocardial infarction and it seems possible that this protection is due to its anti-inflammatory effects." 01/01/2015 - "Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats." 01/01/2015 - "Protective effects of Labisia pumila var. alata on biochemical and histopathological alterations of cardiac muscle cells in isoproterenol-induced myocardial infarction rats." 09/01/2014 - "We showed that a 6-week treatment of myocardial infarction-induced HF rats with a selective ALDH2 activator (Alda-1), starting 4 weeks after myocardial infarction at a time when ventricular remodelling and cardiac dysfunction were present, improved cardiomyocyte shortening, cardiac function, left ventricular compliance and diastolic function under basal conditions, and after isoproterenol stimulation. " 03/01/2013 - "Thus, hUCBC ameliorates cardiotoxic effects of isoproterenol and may be of value in the treatment of myocardial infarction."
2.	Heart Failure 08/01/2006 - "However, during heart failure, long-term NCX overexpression over 2 wk significantly improved fractional shortening and dP/dt(max) compared with AdGFP-infected rabbits, both without inotropic stimulation and after beta-adrenergic stimulation with isoproterenol. " 06/01/1992 - "Isoproterenol is therefore effective in controlling myocardial failure during acute rejection despite a reduced sensitivity of the sinoatrial node and myocardial tissue." 01/01/2014 - "Isoproterenol was injected twice with a daily interval in dozes 85, 120, 150 or 180 mg/kg. Echocardiographic study of the heart in 2 weeks revealed obvious attributes of cardiac failure (left ventricular dilatation, lowered ejection fraction) in the groups which have received high cumulative dozes of isoproterenol (300-360 mg/kg). " 07/01/2013 - "The purpose of the present study was to investigate ventricular repolarization in a rat model of isoproterenol-induced heart failure. " 03/01/2011 - "The present study demonstrated prophylactic and therapeutic potential of Terminalia arjuna bark extract in isoproterenol (ISO)-induced chronic heart failure (CHF). "
3.	Necrosis 01/01/2013 - "The objective of the present study was to evaluate the possible protective effects of Tribulus terrestris fruit aqueous extract (TTFAEt) on lipid profile and oxidative stress in isoproterenol (ISO) induced myocardial necrosis in albino Wistar rats. " 03/01/1974 - "Biochemical changes of myocardial necrosis induced by isoproterenol and protective effects of beta-blocker and anti-inflammatory drugs." 06/25/2007 - "This study appraised the efficacy of OA and UA in protecting the heart against oxidative damage induced by isoproterenol, since oxidative injury has been investigated as a potential initiator of myocardial necrosis. " 01/01/1998 - "Role of Lipistat in protection against isoproterenol induced myocardial necrosis in rats: a biochemical and histopathological study." 10/05/2015 - "The present study was carried out to evaluate the protective effect of different statins on isoproterenol (ISO) induced myocardial necrosis. "
4.	Tachycardia (Tachyarrhythmias) 01/01/2003 - "In vivo studies indicated significantly improved therapeutic efficacy of MT from Ms with sustained and controlled inhibition of isoprenaline-induced tachycardia as compared with oral and nasal administration of drug solution." 10/01/1984 - "Drugs effective against induction of isoproterenol-facilitated ventricular tachyarrhythmias were identified in 13 of 25 trials. " 10/01/2009 - "Comparative pharmacokinetic-pharmacodynamic studies with four beta blockers were performed in conscious rats, using heart rate under isoprenaline-induced tachycardia as a pharmacodynamic endpoint. " 12/01/2005 - "The study population consists of nine children, age range 6-13 years (median 9) with previously documented SVT who had no tachyarrhythmia inducible during EP study (at baseline and following isoprenaline infusion). " 10/01/2001 - "Rapid atrial pacing under the influence of isoproterenol, during an electrophysiology study, elicited and AV nodal reentry tachycardia of the common type. "
5.	Asthma (Bronchial Asthma) 09/01/1984 - "There was no significant difference in the unstimulated cAMP levels before exercise in the three groups, but stimulation with isoprenaline caused a significantly greater rise in cAMP in the non-atopic, non-asthmatic subjects when compared to both the atopic asthmatics and the atopic subjects without asthma. " 04/01/1975 - "Notable acute improvement in pulmonary function in the majority of 32 patients with known bronchial asthma followed two inhalations of Isoproterenol. " 06/01/2004 - "Despite the controversy of bronchial responsiveness to beta2-agonist drugs in asthma, in a previous study we have shown increased responsiveness of asthmatic tracheobronchial tree to isoprenaline. " 12/01/2003 - "Despite the controversy of airway responsiveness to beta2-agonist drugs in asthma, in a previous study we showed increased responsiveness of asthmatic airways to isoprenaline. " 01/13/1948 - "A clinical and experimental study of isuprel in spontaneous and induced asthma."

Related Drugs and Biologics

1.	Epinephrine (Adrenaline)
2.	Norepinephrine (Noradrenaline)
3.	Propranolol (Inderal)
4.	Adenylate Cyclase (Adenylyl Cyclase)
5.	Atropine (Hyoscyamine)
6.	Isoproterenol (Isoprenaline)
7.	Aminophylline (Carine)
8.	Enzymes
9.	Adenosine Triphosphatases (ATPase)
10.	Adrenergic Receptors (Adrenergic Receptor)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Respiratory Therapy (Therapy, Respiratory)
3.	Oral Administration
4.	Injections
5.	Nebulizers and Vaporizers (Inhaler)