Isoleucine (L-Isoleucine)

An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.

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Networked: 1296 relevant articles (24 outcomes, 97 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Tobias, Deirdre K: 10 articles (01/2022 - 01/2018)
2.	Manson, JoAnn E: 8 articles (01/2022 - 10/2016)
3.	Ala-Korpela, Mika: 7 articles (04/2022 - 07/2012)
4.	Mora, Samia: 7 articles (01/2022 - 01/2018)
5.	Scaini, Giselli: 7 articles (01/2022 - 05/2012)
6.	Streck, Emilio L: 7 articles (01/2022 - 05/2012)
7.	Holecek, Milan: 7 articles (01/2016 - 05/2010)
8.	Hu, Frank B: 6 articles (01/2022 - 05/2016)
9.	Mamtimin, Batur: 6 articles (03/2016 - 02/2011)
10.	Baldwin, Ian T: 6 articles (03/2015 - 04/2004)

Related Diseases

1.	Sepsis (Septicemia) 03/01/1985 - "In sepsis, perfusion with leucine and isoleucine resulted in a mild improvement in systolic function. " 07/01/1988 - "Although the BCAA isoleucine and valine were taken up to a greater extent in sepsis, the overall BCAA uptake was not significantly greater in sepsis than in control (CON 6.92 +/- 2.15 mumol/g liver protein vs CLP 15.8 +/- 1.9 mumol/g liver protein). " 03/01/1985 - "However, valine was far less effective than leucine and isoleucine in maintaining systolic function in sepsis, due apparently to valine being a less efficient energy substrate for the cardiac muscle in a state of severe energy deficit. " 09/01/1985 - "In contrast, the clearances of branched-chain AA (BCAA) valine and isoleucine were maintained, and the clearance of leucine was higher (p less than 0.05) in trauma patients with sepsis than in those without. " 01/01/2022 - "Data showed that phenylalanine was significantly higher in sepsis patients compared to healthy controls, whereas isoleucine, valine and histidine were significantly lower in sepsis patients compared to healthy controls. "
2.	Neoplasms (Cancer) 04/16/2015 - "This combination was as effective in killing cancer cells as highly active recombinant isoleucine-zipper-tagged TRAIL (iz-TRAIL). " 10/27/2023 - "The cytotoxicity evaluation of Zn(II) isoleucine dithiocarbamate against MCF-7 cells obtained an IC50 value of 362.70 µg/mL indicating moderate cytotoxicity and morphological changes of cancer cells causing cancer cells to undergo apoptosis. " 10/27/2023 - "This suggests that the Zn(II) isoleucine dithiocarbamate complex could be a promising candidate for cancer treatment with potential HIF1 inhibition properties. " 02/23/2023 - "Overall, our results provide insights into the regulation of the IARS-PTEN anti-tumor axis by isoleucine and reveal a unique therapeutic approach based on enhancing cellular isoleucine supply." 02/23/2023 - "At the same time, IARS knockout leads to loss of isoleucine tumor suppressor ability. "
3.	Muscular Atrophy (Muscle Atrophy) 01/01/2021 - "Interestingly, a positive correlation was observed between plasma isoleucine, aspartate, and glutamate concentrations and improvement in the biceps femoris muscle atrophy. " 01/01/2021 - "Branched Chain Amino Acids (BCAAs: leucine, isoleucine, valine) supplements can be beneficial for counteracting muscle atrophy, in virtue of their reported anabolic properties. "
4.	Obesity 09/01/2007 - "In an analysis of all studies, individuals carrying the isoleucine allele had an 18% (95% confidence interval 4-30%, P=0.015) lower risk of obesity compared with non-carriers. " 05/27/2021 - "In contrast, isoleucine consumption is significantly higher in all groups of subjects with obesity, particularly in Ob+Pre-T2D, compared to Non-Ob. " 01/01/2021 - "Our results reveal isoleucine as a key regulator of metabolic health and the adverse metabolic response to dietary BCAAs and suggest reducing dietary isoleucine as a new approach to treating and preventing obesity and diabetes." 05/01/2014 - "Inasmuch as these factors underlie obesity comorbidities, it may important to identify obese individuals with elevated alloisoleucine." 05/01/2014 - "Therefore, alloisoleucine was investigated in these two obesity models. "
5.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/01/2022 - "All three metabolites were supported by robust Mendelian randomization measures and sensitivity analyses; estrone-3-sulphate and isoleucine were confirmed in a validation amyotrophic lateral sclerosis genome-wide association study. " 01/01/2022 - "Serum isoleucine was positively associated with amyotrophic lateral sclerosis risk. " 01/01/2022 - "Multivariable Mendelian randomization revealed that the toxic effect of isoleucine is dependent on the depletion of vitamin B12; consistent with this, rare variants which reduce the function of MMUT are protective against amyotrophic lateral sclerosis. " 01/01/2022 - "We propose that amyotrophic lateral sclerosis patients and family members with high serum isoleucine levels should be offered supplementation with vitamin B12." 09/01/1995 - "We report here a novel point mutation in exon 5 of the Cu/Zn superoxide dismutase (SOD) gene resulting in an amino acid substitution of valine(148) by isoleucine (V148I) in a Japanese family with amyotrophic lateral sclerosis (FALS). "

Related Drugs and Biologics

1.	Valine (L-Valine)
2.	Leucine (L-Leucine)
3.	Branched-Chain Amino Acids
4.	Amino Acids
5.	Phenylalanine (L-Phenylalanine)
6.	Threonine (L-Threonine)
7.	Proteins (Proteins, Gene)
8.	Glutamic Acid (Glutamate)
9.	Arginine (L-Arginine)
10.	Aspartic Acid (Aspartate)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Infusions
3.	Protein-Restricted Diet (Diet, Protein Restricted)
4.	Continuous Positive Airway Pressure
5.	Nephrectomy