Isoleucine (L-Isoleucine)

An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.

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Networked: 699 relevant articles (10 outcomes, 49 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Holecek, Milan: 6 articles (01/2015 - 05/2010)
2.	Baldwin, Ian T: 5 articles (03/2015 - 11/2008)
3.	Mamtimin, Batur: 5 articles (10/2014 - 02/2011)
4.	Wajner, Moacir: 4 articles (10/2015 - 05/2007)
5.	Upur, Halmurat: 4 articles (10/2014 - 02/2011)
6.	Shimomura, Yoshiharu: 4 articles (01/2014 - 06/2009)
7.	Soeters, Peter B: 4 articles (11/2008 - 06/2004)
8.	Mescka, Caroline Paula: 3 articles (10/2015 - 02/2013)
9.	Wayhs, Carlos Alberto Yasin: 3 articles (10/2015 - 02/2013)
10.	Guerreiro, Gilian: 3 articles (10/2015 - 02/2013)

Related Diseases

1.	Sepsis (Septicemia) 07/01/1988 - "Although the BCAA isoleucine and valine were taken up to a greater extent in sepsis, the overall BCAA uptake was not significantly greater in sepsis than in control (CON 6.92 +/- 2.15 mumol/g liver protein vs CLP 15.8 +/- 1.9 mumol/g liver protein). " 03/01/1985 - "In sepsis, perfusion with leucine and isoleucine resulted in a mild improvement in systolic function. " 03/01/1985 - "However, valine was far less effective than leucine and isoleucine in maintaining systolic function in sepsis, due apparently to valine being a less efficient energy substrate for the cardiac muscle in a state of severe energy deficit. " 09/01/1985 - "In contrast, the clearances of branched-chain AA (BCAA) valine and isoleucine were maintained, and the clearance of leucine was higher (p less than 0.05) in trauma patients with sepsis than in those without. " 01/01/2015 - "Of special importance might be isoleucine deficiency in bleeding from varices, arginine deficiency in sepsis, and a marked rise of GLN and ammonia levels that may appear in all events leading to HE. "
2.	Neoplasms (Cancer) 04/16/2015 - "This combination was as effective in killing cancer cells as highly active recombinant isoleucine-zipper-tagged TRAIL (iz-TRAIL). " 01/01/2014 - "Cytotoxicity evaluation against four cancer cell lines showed that N-sapienoyl isoleucine was active against three cell lines whereas other derivatives either showed activity against only one or two cell lines with very moderate activity and two derivatives were observed to be inactive against the tested cell lines." 03/01/2001 - "We have also demonstrated that the addition of an isoleucine zipper to the N-terminal of TRAIL greatly enhanced the trimerization of the fusion protein and dramatically increased its anti-tumor activity. " 07/01/2015 - "MSCs were transduced with lentiviruses expressing flT or an isoleucine zipper-fused sT. TRAIL expression was examined and cancer cell apoptosis was measured after treatment with transduced MSCs or with MSC-derived soluble TRAIL. " 01/01/1979 - "N-Ethyloxycarbonylaminomehyl-L-isoleucine (A-145), a novel antitumor amino acid derivative, is an anti-tumor agent effect in cases of Ehrlich ascites rather than against Sarcoma-180. "
3.	Liver Failure 10/10/2015 - "Leucine (Leu), isoleucine (Ile) and valine (Val) are three branched-chain amino acids (BCAAs), which have been widely used as dietary supplements for professional athletes and patients with liver failure or catabolic diseases. " 01/01/2011 - "Aminoleban® EN, a nutritional product for patients with liver failure, contains three branched-chain amino acids (BCAAs): L-leucine, L-isoleucine, and L-valine. " 11/01/2007 - "Nutritional products for patients with liver failure available on the Japanese market contain many branched-chain amino acids (BCAAs) such as L-leucine, L-isoleucine, and L-valine, which not only have a bitter taste but also strong, unpleasant odours, leading to low palatability. " 05/01/1999 - "This study aimed to investigate profiles of the amino acid molar ratio, the Fischer molar ratio (FR, valine + leucine + isoleucine/phenylalanine + tyrosine), and relationships with other nutritional parameters and to assess the efficacy of enteral nutrient preparations for hepatic failure in patients with BA. " 06/01/2013 - "The pretreatment amino acid plasma profiles were typical for hepatic failure, with abnormally high levels of phenylalanine and tyrosine as well as decreased valine, leucine, and isoleucine. "
4.	Hepatocellular Carcinoma (Hepatoma) 05/01/1980 - "Concentration and clearance of Tc-99m-pyridoxylidene isoleucine by a hepatoma." 05/01/1980 - "This report involves a rare case in which a hepatoma did not take up Tc-99m-phytate, but concentrated and cleared a Tc-99m-hepatobiliary agent, Tc-99m-pyridoxylidene isoleucine." 01/15/1982 - "The regulation of thymidylate synthetase activity was investigated throughout the first cell cycle after release from an isoleucine block in synchronous cultures of mouse hepatoma (Hepa) cells. " 12/01/1998 - "Stored sera from asymptomatic hepatitis B virus (HBV) carriers and hepatitis B virus surface antigen-positive hepatocellular carcinoma (HCC) patients were tested for HBV subtypes, such as subtype determinants d, y, w, r and also antigenic determinants isoleucine (i) and threonine (t) by direct S gene nucleotide sequencing. " 08/01/2005 - "In this study, wild-type and mutants of the X gene, including the point mutations at codons 130 (AAG-->ATG, lysin-->methionine) and 131 (GTC-->ATC, valine-->isoleucine), commonly found in patients with human hepatocellular carcinoma (HCC), or deletions encompassing the same region, were cloned and inserted into expression vectors. "
5.	Starvation 01/01/2013 - "The results revealed complex translational regulation of this pathway, essential to cope with isoleucine starvation.To" 01/01/2013 - "Under isoleucine starvation, half of the mRNAs considered were translationally down-regulated mainly due to decreased ribosome density. " 01/01/2013 - "To identify the translational response of bacteria in stress conditions and assess its contribution to the regulation of gene expression, the translational states of all mRNAs were compared under optimal growth condition and during nutrient (isoleucine) starvation. " 01/01/2013 - "Interestingly, degradation control increased during the dynamic adaptation of bacteria as the growth rate reduced due to progressive isoleucine starvation in batch cultures. " 01/01/2013 - "The model bacterium Lactococcus lactis was used and different growth rates were studied in continuous cultures under isoleucine-limitation and in batch cultures during the adaptation to the isoleucine starvation. "

Related Drugs and Biologics

1.	Valine (L-Valine)
2.	Leucine (L-Leucine)
3.	Threonine (L-Threonine)
4.	Branched-Chain Amino Acids
5.	Amino Acids
6.	Phenylalanine (L-Phenylalanine)
7.	Tyrosine (L-Tyrosine)
8.	Arginine (L-Arginine)
9.	Tryptophan (L-Tryptophan)
10.	Lysine (L-Lysine)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Nephrectomy
3.	Oral Administration
4.	Ketogenic Diet
5.	Transjugular Intrahepatic Portasystemic Shunt