Isoenzymes

02/01/2015 - "Besides TH metabolism, several studies indicate an important role of DIO isoenzymes in tumorigenesis and cancer growth. "
10/01/2011 - "The aim of this study was to compare the metabolism of cervical cancer cells and normal cervical cells by measurement of ADH isoenzymes and ALDH activities. "
03/13/2006 - "Over the last three decades, data from cancer studies have linked aberrant expression of GST isozymes with the development and expression of resistance to a variety of chemicals, including cancer drugs. "
06/01/2004 - "Selective inhibition of membrane-associated CA isozymes is relevant indeed in many physiological studies and also pharmacologically, since the tumor-associated isozymes (CA IX and XII) are both membrane-bound."
06/01/2000 - "In an earlier study, it was shown that the expression pattern of PKC isoenzymes is altered in some tumors compared to their corresponding normal tissue. "

01/01/1994 - "Serum levels of T.LDH as well as all the five isoenzymes were significantly lower in leukemia patients in remission as compared to untreated leukemia patients. "
08/01/1997 - "The different therapeutic options that may be employed in the treatment of elderly patients with acute leukemias and myelodysplastic states are considered following an analysis of certain biological features, that have been investigated by cytochemical, cytogenetic and cytokinetic techniques, immunophenotyping, and studies on G-6-PD isoenzymes. "
01/01/1994 - "The study indicated that alterations in T.LDH and its isoenzymes are useful for diagnosis and treatment monitoring of leukemia."
05/15/1996 - "We conclude that measurements of serum levels of total LDH, human LDH isoenzymes, and NMP 41/7 are sensitive, quantitative, rapid, and easy to perform serologic methods useful to monitor the engraftment, progression, and treatment response of human leukemia in SCID mice."
04/01/1995 - "The 1.6 kb transcript was translated into two isozymes (isozyme I and II), while the 1.0 kb transcript was only translated into isozyme I. These results suggest that the two isozymes deduced from the cDNAs of the human erythroid leukemia cells may exist in normal human erythrocytes."

05/01/1995 - "In patients with acute pancreatitis, increase of Amylase-1 and -2 is accompanied by the appearance of Amylase-4, a minor component of the pancreatic-type isoamylases, and by disappearance of the salivary-type isoenzymes, thereby leaving a pattern of the pancreatic isoenzymes alone. "
06/01/1977 - "[Enymes and isoenzymes of the blood serum in acute pancreatitis]."
01/01/1991 - "Moreover, additional isoenzymes were found in all patients with severe acute pancreatitis or pseudocysts, and not in controls or patients with mild forms, acute abdomen or duodenal duplication. "
09/01/1976 - "Patients with mumps had elevations of salivary-type isozymes, while those with pancreatitis had elevations of pancreatic-type isozymes. "
03/01/1975 - "The determination of the blood serum LDG isoenzymes activity as a test supplementing other methods of investigation may, with due account of the clinico-electrocardiographic picture, be used in the differential diagnosis of myocardial infarction and acute pancreatitis."

10/01/1976 - "The isoenzymes were helpful in excluding the diagnosis of pancreatic in 1 renal failure patient whose hyperamylasemia was primarily salivary in origin and in confirming the diagnosis in another who had only a pancreatic band."
05/01/2009 - "Dabigatran is mainly eliminated by renal excretion (a fact which affects the dosage in elderly and in moderate-severe renal failure patients), and no hepatic metabolism by cytochrome P450 isoenzymes has been observed, showing a good interaction profile. "
09/01/2002 - "The aim of this study was to test the utility of serum alkaline phosphatase isoenzymes determination from patients with renal insufficiency. "
09/01/2002 - "[Alkaline phosphatase isoenzymes in the serum of patients with renal insufficiency]."
10/01/2001 - "Atypical alkaline phosphatase isozymes in serum and urine of patients with renal failure."

08/03/2001 - "In this study, the spatiotemporal expression of DGK isozymes was investigated in rat hearts under a normal condition and after myocardial infarction (MI) by in situ hybridization histochemistry and immunohistochemistry. "
10/01/1996 - "The present study was undertaken to determine changes in the activity of PGM and its isoenzymes after acute myocardial infarction.Methods"
01/01/1989 - "A comprehensive study of these isozymes is a reliable criterion of the diagnosis of myocardial infarction. "
06/01/2010 - "The patient had subendocardial myocardial infarction (MI) with positive electrocardiogram (EKG) findings and elevated levels of cardiac isoenzymes. "
03/01/2001 - "The results show that intrinsic to the pathophysiology of post-myocardial infarction CHF are abnormalities of SL PLA(2) isoenzymes, suggesting that PLA(2)-mediated bioprocesses are altered in CHF."