Isoamylase

An enzyme that hydrolyzes 1,6-alpha-glucosidic branch linkages in glycogen, amylopectin, and their beta-limit dextrins. It is distinguished from pullulanase (EC 3.2.1.41) by its inability to attack pullulan and by the feeble action of alpha-limit dextrins. It is distinguished from amylopectin 6-glucanohydrolase (EC 3.2.1.69) by its action on glycogen. With EC 3.2.1.69, it produces the activity called "debranching enzyme". EC 3.2.1.68.

Also Known As:

Networked: 181 relevant articles (9 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dagash, Haitham: 1 article (01/2015)
2.	Rajimwale, Ashok: 1 article (01/2015)
3.	Durell, Jonathan: 1 article (01/2015)
4.	Boam, Tristan: 1 article (01/2015)
5.	Catanzaro, R: 1 article (10/2012)
6.	Italia, A: 1 article (10/2012)
7.	Durie, Peter R: 1 article (07/2010)
8.	Ip, Wan F: 1 article (07/2010)
9.	Stormon, Michael O: 1 article (07/2010)
10.	Ellis, Lynda: 1 article (07/2010)

Related Diseases

1.	Chronic Pancreatitis 10/01/1990 - "In the group with chronic pancreatitis studied during painful relapse, 16 had an increase in P-isoamylase, as determined with the immunoinhibition assay, 13 with the wheat germ inhibition test, and 15 with electrophoresis. " 07/01/1986 - "As for P-isoamylase, a statistical difference was detected only between mean peak concentrations of control versus chronic pancreatitis. " 11/01/1984 - "Only two out of 8 patients with elevated isoamylase P had chronic pancreatitis. " 10/01/1984 - "A low value of pancreatic isoamylase strongly supports a diagnosis of chronic pancreatitis and may obviate the need for further investigation." 10/01/1984 - "The mean pancreatic isoamylase in those with chronic pancreatitis (68 +/- 77 IU/l) was significantly lower (p less than 0.005) than in controls (113 +/- 60 IU/l). "
2.	Hyperamylasemia 05/01/1982 - "The purpose of this study was to determine if routine isoamylase assay would provide valuable diagnostic information in patients with hyperamylasemia. " 01/01/2015 - "A hyperamylasemia was noted, and further characterised by a fractionated isoamylase test, as being predominantly of the salivary type. " 05/01/1998 - "Hyperamylasemia occurred from 6 to 24 hours after the CABG and was mainly caused by pancreatic isoamylase. " 05/01/1995 - "The most useful and accurate method for distinguishing pancreatic from salivary-type hyperamylasemia is isoamylase analysis by electrophoresis. " 08/01/1992 - "2. The isoamylase pattern of postoperative hyperamylasemia was dominant in the salivary type. "
3.	Pancreatitis 06/01/1991 - "An increase in pancreatic isoamylase was found in 27% of the patients; however, none of them had clinical symptoms of pancreatitis. " 01/01/1989 - "A lack of a correlation with steroid therapy and a need to document pancreatitis in a multisystem disease like lupus with radiographic evidence as well as pancreatic isoamylase elevations is emphasized." 06/01/1987 - "Total pancreatic (P-type) isoamylase was elevated in 89% of patients with clinical evidence of pancreatitis, and in only 11% of those without pancreatitis. " 05/01/1987 - "It is suggested that isoamylase P3 determination is the most sensitive assay to screen for the complications of acute pancreatitis." 07/01/1986 - "We sought to determine whether the clinical diagnosis of pancreatitis was supported by elevated serum levels of pancreatic isoamylase, currently the most specific test for pancreatitis. "
4.	Pancreatic Diseases (Pancreatic Disease) 03/01/1991 - "Serum pancreatic isoamylase activity in pancreatic disease." 01/01/1991 - "Fecal isoamylase activity in patients with pancreatic diseases." 07/01/1990 - "Diagnostic utility of a new monoclonal antibody pancreatic isoamylase assay in chronic pancreatic diseases." 11/01/1988 - "Serum isoamylase activities in pancreatic diseases." 09/01/1983 - "Assessment of a rapid pancreatic isoamylase assay as a screening test for chronic pancreatic disease."
5.	Abdominal Pain (Pain, Abdominal) 01/01/2003 - "A 70-year-old man was admitted to our hospital because of abdominal pain with an elevated serum pancreatic isoamylase level. " 05/01/1983 - "Although nine of the 58 patients had abdominal pain and clinical symptoms suggestive of acute pancreatitis, none of these patients had elevated pancreatic isoamylase. " 10/01/1992 - "Total amylase and salivary (S) type isoamylase were measured in serum from 80 women with acute abdominal pain admitted to the Department of Gynecology. " 08/01/1982 - "Since hyperamylasemia with or without abdominal pain is a frequently encountered problem, serum isoamylase analysis in 52 patients was done to see if the organ source of the amylase would be helpful in a clinical setting. " 06/01/1998 - "She subsequently complained of abdominal pain; this was associated with a slight elevation of serum pancreatic isoamylase and lipase levels, and a huge pancreatic pseudocyst was detected. "

Related Drugs and Biologics

1.	Amylases
2.	Lipase (Acid Lipase)
3.	Enzymes
4.	Trypsinogen
5.	Pancreatic Elastase (Elastase)
6.	Isoenzymes
7.	alpha-Amylases
8.	acetylcellulose
9.	Barium
10.	macroamylase

Related Therapies and Procedures

1.	Neck Dissection (Radical Neck Dissection)
2.	Transplants (Transplant)
3.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
4.	Laparotomy
5.	Intramuscular Injections