Iron

A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.

Networked: 29267 relevant articles (1162 outcomes, 3702 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ganz, Tomas: 78 articles (08/2015 - 10/2002)
2.	Nemeth, Elizabeta: 75 articles (08/2015 - 04/2003)
3.	Swinkels, Dorine W: 71 articles (12/2015 - 11/2004)
4.	Richardson, Des R: 68 articles (10/2015 - 01/2002)
5.	Wood, John C: 61 articles (09/2015 - 03/2004)
6.	Camaschella, Clara: 52 articles (12/2015 - 05/2002)
7.	Youdim, Moussa B H: 52 articles (09/2015 - 01/2002)
8.	Porter, John B: 49 articles (09/2015 - 06/2002)
9.	Brissot, Pierre: 49 articles (02/2015 - 01/2002)
10.	Barton, James C: 48 articles (12/2015 - 02/2003)

Related Diseases

1.	Anemia 02/01/2013 - "Although the anemia in the three treated groups was resolved after 3 and 12 weeks of oral iron therapy, we conclude that the regimen of two doses per week is the most effective in resolving anemia with less cost and fewer side effects." 04/15/2011 - "Most anemias were asymptomatic and improved with iron/multivitamin supplementation and cessation of ZDV exposure. " 05/01/2004 - "The regimen with iron administered daily is still the best option for treating anemia. " 02/15/2003 - "The combination of IPT and iron supplementation was most effective in the treatment of mild anemia. " 09/01/2001 - "Paired analysis of 875 patients present in 1996 and 1998 showed that, although there was a marked increase in the use of IV iron, the improvement in anemia was modest, and there was evidence for increased iron accumulation. "
2.	Iron Overload 12/05/2014 - "Several studies have shown that targeting iron absorption could be beneficial in reducing or preventing iron overload in these 2 disorders, with promising preclinical data. " 06/01/2015 - "Conclusion DFX significantly improved iron metabolism in HD patients with iron overload and had an acceptable frequency of adverse effects. " 02/01/2014 - "Primary endpoint was regarded as significant improvement in the severity of liver and cardiac iron overload in severe and moderate cases, in addition to improvement or maintenance of the grade of severity in patients with mild iron overload or normal iron accumulation. " 06/10/2011 - "Iron-chelating therapy results in a significant improvement in the life expectancy of patients with transfusional iron overload. " 01/01/2008 - "There was a significant difference in disease-free and overall survival (35.8 and 27% in the iron overload group vs. 80.6 and 54.6% in the iron non-overload group; p = 0.01 and 0.03, respectively). "
3.	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 01/01/2005 - "The prevalence of iron deficiency anemia (IDA) during the first year of life has been dramatically reduced in developed countries, mainly due to the increase in breastfeeding and the use of iron-fortified feeding formulae. " 03/01/2001 - "We concluded that the use of sweet rolls fortified with 2 mg of iron from the bis-glycinate chelate is highly effective for the control of iron deficiency and iron deficiency anemia in young children." 03/01/2011 - "A previous study among schoolchildren supplemented with iron-fortified rice showed a significant reduction in the rate of iron-deficiency anemia from 100% to 33%. " 09/01/2007 - "Because biscuits are a popular snack item and are consumed frequently by the younger population, fortification of biscuits with iron can be beneficial in preventing iron-deficiency anemia, which is widely prevalent in developing countries. " 10/01/2005 - "This suggests that high iron-demand reproductive functions helped to make iron-deficiency anemia a chronic condition in many women's lives irrespective of their status affiliation."
4.	Infection 08/01/2012 - "Variables related to health status and infection transmission, such as iron status and number of siblings, are important for the incidence and spontaneous clearance of H pylori infection." 07/01/2004 - "pylori infection improved gastric acid output but did not significantly influence iron absorption. " 06/01/2002 - "Remarkably, in a mouse model of systemic infection, the Caccc2Delta strain displayed robust proliferation and no significant reduction in pathogenicity, suggesting the existence of alternative mechanisms of iron uptake from host tissues. " 08/15/1994 - "The iron-treatment before the infection resulted in a significant reduction in the LD50 of virulent strains. " 08/01/1983 - "In comparison with normal rats, those with iron deficiency anaemia showed no significant difference in susceptibility to experimental infection with Candida albicans although anaemic rats had a significantly greater incidence of persistent infection. "
5.	Neoplasms (Cancer) 07/01/2015 - "Here, we found a significant reduction of FPN levels in prostate tumors relative to adjacent tissues, and demonstrated a crucial role of FPN in tumor growth through controlling tumor iron concentration. " 03/15/2013 - "7T MR images obtained at 16 hours posttreatment revealed a significant reduction in signal indicating the presence of iron-loaded NK-92 cells at the tumor site. " 03/01/2008 - "The number of positive voxels detected around small and medium tumors was significantly greater with the SGM technique than with the White Marker and IRON techniques. " 05/01/1997 - "High-dispersion iron endowed with certain physical and chemical and medical and biological characteristics was shown to be helpful in treating malignant tumors of the brain. " 07/01/1981 - "It has been recently found that the clearance of 67Ga from blood and the attainment of high ratios of the tumor to normal soft-tissue concentrations are accelerated, if the serum iron concentration is high. "

Related Drugs and Biologics

1.	Deferoxamine (Desferal)
2.	Erythropoietin
3.	Ferritins (Ferritin)
4.	Chelating Agents
5.	Hemoglobins (Hemoglobin)
6.	deferiprone (CP20)
7.	deferasirox
8.	saccharated ferric oxide
9.	hepcidin
10.	Transferrin (beta 2 Transferrin)

Related Therapies and Procedures

1.	Chelation Therapy (Therapy, Chelation)
2.	Renal Dialysis (Hemodialysis)
3.	Blood Transfusion (Blood Transfusions)
4.	Drug Therapy (Chemotherapy)
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)