Iris Diseases

Diseases, dysfunctions, or disorders of or located in the iris.

Also Known As:

Disease, Iris; Diseases, Iris; Iris Disease

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Eye Diseases: 3522
- Uveal Diseases: 16
  - Iris Diseases: 5

Related Diseases

1.	Glaucoma
2.	Retinal Neovascularization
3.	Retinopathy of Prematurity (Retrolental Fibroplasia)
4.	Melanoma (Melanoma, Malignant)
5.	Hemorrhage

Experts

1.	John, Simon W M: 3 articles (03/2014 - 07/2006)
2.	Masli, Sharmila: 2 articles (03/2014 - 04/2008)
3.	Nair, K Saidas: 2 articles (03/2014 - 04/2008)
4.	Smith, Richard S: 2 articles (03/2014 - 07/2006)
5.	Anderson, Michael G: 2 articles (04/2008 - 07/2006)
6.	Akkoyun, Imren: 1 article (01/2021)
7.	Sahinoglu-Keskek, Nedime: 1 article (01/2021)
8.	Torer, Birgin: 1 article (01/2021)
9.	Barbay, Jessica: 1 article (03/2014)
10.	Chou, Tsung-Han: 1 article (12/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Iris Diseases:

1.	Monophenol Monooxygenase (Tyrosinase)IBA 07/07/2006 - "Genetic epistasis experiments introducing a B6 tyrosinase mutation into the congenic strains demonstrated that both the single and double-congenic iris diseases are rescued by interruption of melanin synthesis. " 12/31/2010 - "C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse strains; D2 has two mutated genes, tyrosinase-related protein 1 (Tyrp1) and glycoprotein non-metastatic melanoma protein B (Gpnmb), causing iris disease and intraocular pressure (IOP) elevation after 6 months of age that results in RGC degeneration, and is the most widely used model of glaucoma. "
2.	Proteins (Proteins, Gene)FDA Link 03/28/2014 - "Mutations in two melanosomal protein genes (Tyrp1(b) and Gpnmb(R150X)) are responsible for pigment dispersing iris disease, which progresses to intraocular pressure (IOP) elevation and subsequent glaucoma in DBA/2J mice. " 12/31/2010 - "C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse strains; D2 has two mutated genes, tyrosinase-related protein 1 (Tyrp1) and glycoprotein non-metastatic melanoma protein B (Gpnmb), causing iris disease and intraocular pressure (IOP) elevation after 6 months of age that results in RGC degeneration, and is the most widely used model of glaucoma. "
3.	Interleukin-18 (Interleukin 18)IBA 04/10/2008 - "Finally, we show that the Gpnmb mediated iris disease does not require elevated IL18 or mature B or T lymphocytes. "
4.	Melanins (Melanin)IBA 07/07/2006 - "Genetic epistasis experiments introducing a B6 tyrosinase mutation into the congenic strains demonstrated that both the single and double-congenic iris diseases are rescued by interruption of melanin synthesis. "
5.	Glycoproteins (Glycoprotein)IBA 12/31/2010 - "C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse strains; D2 has two mutated genes, tyrosinase-related protein 1 (Tyrp1) and glycoprotein non-metastatic melanoma protein B (Gpnmb), causing iris disease and intraocular pressure (IOP) elevation after 6 months of age that results in RGC degeneration, and is the most widely used model of glaucoma. "
6.	Ranibizumab (Lucentis)FDA Link 01/01/2021 - "The documented data were gestational age, birth weight, gender, postmenstrual age at intravitreal ranibizumab injection, zone of retinopathy of prematurity, reactivation time of disease, iris neovascularization, retinal hemorrhage, anatomical outcome, and additional treatment. "
7.	IgA receptor (protein B)IBA 12/31/2010 - "C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse strains; D2 has two mutated genes, tyrosinase-related protein 1 (Tyrp1) and glycoprotein non-metastatic melanoma protein B (Gpnmb), causing iris disease and intraocular pressure (IOP) elevation after 6 months of age that results in RGC degeneration, and is the most widely used model of glaucoma. "