Ions

An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.

Networked: 4281 relevant articles (101 outcomes, 316 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Debus, Jürgen: 37 articles (09/2015 - 05/2002)
2.	Durante, Marco: 19 articles (10/2015 - 12/2002)
3.	Haberer, Thomas: 17 articles (09/2015 - 05/2002)
4.	Jäkel, Oliver: 17 articles (09/2015 - 05/2002)
5.	Faller, Peter: 15 articles (11/2015 - 06/2007)
6.	Combs, Stephanie E: 14 articles (01/2015 - 01/2010)
7.	Ando, Koichi: 13 articles (11/2015 - 09/2002)
8.	Tsujii, Hirohiko: 13 articles (02/2015 - 06/2004)
9.	Hureau, Christelle: 12 articles (11/2015 - 02/2009)
10.	Scholz, Michael: 12 articles (10/2015 - 08/2002)

Related Diseases

1.	Neoplasms (Cancer) 08/08/2006 - "Water-generated negative ions had a long life, significantly enhanced the cytotoxic activity of natural killer cells, and significantly decreased the incidence of cancer and inhibited tumor growth. " 04/21/2015 - "Besides, the dose conformation is improved for deep-seated tumors compared to (1)H, and the damage to surrounding healthy tissues is reduced compared to heavier ions due to the lower impact of nuclear fragmentation. " 11/01/2015 - "In vitro studies have shown a significant amplification of the biological damage in tumor cells charged with nanoparticles and irradiated with fast ions. " 06/26/2015 - "Patients with skull tumors treated by (12)C ions and volunteers whose posterior portion of the eye was exposed to highly ionizing particles in early studies reported comparable percepts. " 01/01/2015 - "Employing an APC-mutant mouse model (APC(Min/+)) the present study aimed to investigate the status of RXRα, an APC-independent factor involved in targeting β-catenin to UPP for degradation, in tumor-bearing and tumor-free areas of intestine after exposure to energetic (56)Fe ions. "
2.	Ischemia 11/01/1995 - "The ability to detail the changes in ions, metabolites, and high-energy phosphate compounds in both the extracellular and intracellular spaces and to correlate them directly with the simultaneously occurring electrophysiologic changes have greatly enhanced our understanding of the electrical events that characterize the ischemic process and hold promise for permitting studies aimed at developing interventions that may lessen the lethal consequences of ischemia." 03/01/2009 - "Several studies have already provided evidence that gap junction-mediated intercellular diffusion of ions and small molecules during ischemia represents an important mechanism through which necrotic, apoptotic, or even protective signals are transported between cells. " 05/01/1995 - "The purpose of the study was to compare the role of Na ions in the damage caused by cardioplegic ischemia in fast (rat) and slow (pig) hearts. " 05/03/2013 - "We conclude that the opening of Cav3.2 channels during ischemia contribute to the entry of Ca(2+) ions that are transmitted to mitochondria, resulting in a deleterious mitochondrial Ca(2+) overload." 05/15/2008 - "Marked changes in Ca(2+) distribution, compared with other fundamental ions, such as Na(+), K(+), and Mg(2+), were detected during the progression of ischemia. "
3.	Melanoma (Melanoma, Malignant) 04/01/2008 - "We examined expression profiles of 6 melanoma cell lines exposed to C-ions or X-rays with 2 Gy using single-color microarrays. " 01/01/2005 - "While for healthy subjects plasma samples lead to the production of a higher number of ionic species, for melanoma patients a high number of diagnostic ions, present with high frequency and with quite high relative abundance, are present in particular in serum samples and to a lesser extent also in plasma. " 12/01/2004 - "Sets of four parameters (m, E0, sigma0 and kappa) of the cellular track structure model of Katz have been fitted to recently published data concerning human melanoma (AA) and mammalian (V79) cells exposed to a variety of lighter ions and to mixed ion-Co60 and ion-ion irradiation. " 04/01/1998 - "Growth rates of melanoma cells in the presence of 1 mM of metal ions (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Yb3+, Al3+) were significantly lower than that of control cells. " 07/01/2008 - "The expected incomplete saturation of chelates with Gd(III) ions permitted radiometal complexation, and an in vivo tissue distribution of the resulting agent in M21 melanoma tumor-bearing mice showed mostly renal and reticuloendothelial accumulation, with the tumor:blood ratio peaking (3.30+/-0.03) at 2 h postinjection."
4.	Infection 05/01/2008 - "Therefore, it is necessary to further study these materials as well as the characteristics of the superficial film formed in physiologic media in infection conditions in order to control their potential toxicity due to the release of metallic ions in the human body. " 05/01/2003 - "This study has shown that phosphate-based glasses could potentially be used to deliver antibacterial ions to help combat oral infections. " 01/01/2002 - "This study presents evaluation of effects of aluminium ions on the development of experimental infection induced by the injection of Listeria monocytogenes bacteria into growing mice. " 06/12/2015 - "The urine/plasma ratio for Na(+) increased from 0.03 in uninfected carp to 0.43-0.83 in carp under CyHV-3 infection, while concentration of divalent ions were not significantly changed. " 01/01/2015 - "CaPs can be used as local antibiotic delivery agents for bone infections and can be substituted with antibacterial ions in their crystal structure to have a wide spectrum, sustained antibacterial activity even against drug resistant bacteria. "
5.	Alzheimer Disease (Alzheimer's Disease) 04/09/2015 - "The interaction of a series of metal ions (i.e., groups 1 and 2, first-row transition metals, and groups 11-14) with the His13-His14 sequence relevant to Alzheimer's disease has been studied using quantum chemical calculations. " 04/09/2015 - "Interaction of metal ions with the His13-His14 sequence relevant to Alzheimer's disease." 07/31/2014 - "Importantly, with an excess amount of Zn(II) ions, as is the case in brain tissues affected by Alzheimer's disease, component II becomes the dominant coordination mode, as Zn(II) selectively substitutes component I bound to Cu(II). " 07/22/2014 - "Membrane permeability to ions and small molecules is believed to be a critical step in the pathology of Alzheimer's disease (AD). " 01/01/2014 - "An imbalance of metal ions is implicated in the development of Alzheimer's disease (AD). "

Related Drugs and Biologics

1.	Carbon
2.	Silver
3.	Calcium
4.	Protons (Proton)
5.	Copper
6.	Iron
7.	Potassium
8.	Magnesium
9.	Helium
10.	Zinc

Related Therapies and Procedures

1.	Radiotherapy
2.	Fluid Therapy (Oral Rehydration Therapy)
3.	Drug Therapy (Chemotherapy)
4.	Root Planing
5.	Phototherapy (Light Therapy)