Iohexol (Omnipaque)

An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.

Also Known As:

Networked: 464 relevant articles (35 outcomes, 43 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Schwartz, George J: 10 articles (04/2015 - 11/2007)
2.	Furth, Susan L: 9 articles (02/2014 - 11/2007)
3.	Abraham, Alison G: 8 articles (10/2015 - 11/2009)
4.	Warady, Bradley A: 8 articles (02/2014 - 03/2008)
5.	Melsom, Toralf: 6 articles (01/2015 - 12/2010)
6.	Toft, Ingrid: 6 articles (07/2014 - 04/2006)
7.	Solbu, Marit D: 5 articles (07/2014 - 12/2010)
8.	Eriksen, Bjørn O: 5 articles (07/2014 - 12/2010)
9.	Gaspari, Flavio: 4 articles (12/2015 - 01/2007)
10.	Njølstad, Inger: 4 articles (07/2014 - 12/2010)

Related Diseases

1.	Kidney Diseases (Kidney Disease) 04/01/2015 - "To evaluate the accuracy of plasma clearance of iohexol (PCio) for glomerular filtration rate (GFR) measurement in Chinese children with chronic kidney disease (CKD) and assess the feasibility of single-blood-sample method or dried capillary blood spots in determining the PCio. " 04/01/2015 - "Application of plasma clearance of iohexol in evaluating renal function in chinese children with chronic kidney disease." 09/01/2011 - "Data were used from 586 children participating in the Chronic Kidney Disease in Children (CKiD) study (United States and Canada) with GFR measured by iohexol plasma disappearance. " 04/01/2011 - "The Chronic Kidney Disease in Children (CKiD) study uses injected iohexol to obtain direct measures of GFR. " 02/01/2010 - "Study participants were categorized by kidney disease stage (measured by iohexol-based glomerular filtration rate [iGFR]), and group differences in HRQoL were evaluated by using analysis of variance and Cuzick trend tests. "
2.	Body Weight (Weight, Body) 01/01/2008 - "GFR was estimated from the plasma clearance of iohexol, by a compartmental model and an empirical correction formula, normalized to body weight in kilograms or liters of extracellular fluid volume (ECFV). " 02/01/2006 - "In the human study, 20 patients were randomized into four groups: Groups A, B, and C received 1.5, 1.7, and 2.5 mL of iohexol per kilogram of body weight, respectively, over 35 sec; and group D received 1.7 mL/kg over 25 sec. In patient groups A, B, C, and D, phantom protocols 1, 2, 3, and 4 were used, respectively. " 03/01/2015 - "Iohexol CL decreased by 29.8% from baseline value on D10, which was related to body weight loss (Pearson's r = 0.837, P = 0.019). " 09/01/2013 - "This was a prospective study including 348 patients with hypervascular HCC in 77 hospitals as a postmarketing surveillance to investigate the effects of body weight-tailored dose of CM (300 mgI/mL of iohexol) for hepatic multiphasic contrast-enhanced multidetector-row computed tomography imaging. " 07/01/2013 - "The modified Jacobsson method provides accurate estimation of iohexol clearance in cats, from a single sample collected at 180 minutes postinjection and using a formula based on the body weight to predict ECFV. "
3.	Renal Insufficiency (Renal Failure) 03/01/1996 - "The present study examined the agreement between single and multiple sample plasma clearance of iohexol, a non-ionic contrast agent, in renal failure. " 10/01/1998 - "The aim of this study was to determine whether single plasma sampling 4 h after injection of iohexol could accurately determine GFR in diabetic patients with mild to moderate renal failure, compared to multiple plasma sampling. " 06/01/2009 - "Iohexol is an iodinated contrast dye that has been shown to be useful in the estimation of glomerular filtration rate (GFR) in patients with suspected renal insufficiency. " 01/01/2007 - "A 229-patient renal failure validation sample with M/F 166/63, age 53.0 +/- 14.8, GFR 32.0 +/- 14.3 (range 4.3-69.8), assessed using iohexol Cl, was considered to compare the Cockcroft-Gault (C-G) and MDRD formulas with the new equation for estimating GFR. " 01/17/2003 - "Iohexol clearance is a valid method for measuring GFR in patients at any stages of renal failure. "
4.	Neoplasms (Cancer) 07/01/2008 - "IP iohexol significantly improved the accuracy of tumor-burden measurement for both low and high tumor-burdened animals. " 10/08/2014 - "With a demonstrated better X-ray attenuation property than that of clinically used iodinated small molecular contrast agent (e.g., Omnipaque) and the prolonged half-decay time (11.2 h in rat) confirmed by pharmacokinetics studies, the developed PEGylated Au PENPs enabled efficient and enhanced blood pool CT imaging with imaging time up to 75 min. Likewise, thanks to the enhanced permeability and retention effect, the PEGylated Au PENPs were also able to be used as a contrast agent for effective CT imaging of a tumor model. " 02/01/2015 - "The resulting GO/BaGdF5/PEG shows low cytotoxicity, positive magnetic resonance (MR) contrast effect and better X-ray attenuation property than Iohexol, which enables effective dual-modality MR and X-ray computed tomography (CT) imaging of the tumor model in vivo. " 05/01/2011 - "As a method control for GFR obtained by iohexol clearance, group A and B together were compared to 298 pediatric patients without cancer, group C. " 07/01/2008 - "The combination of IP iohexol with Fenestra provides superior delineation of liver tumors, in comparison to Fenestra alone. "
5.	Headache (Headaches) 01/01/1989 - "Headache incidence was significantly greater after 20G needle myelography (44%, n = 97) as compared to 22G needle iohexol myelography (26%, n = 58). " 01/01/1989 - "Nineteen publications were reviewed and subjected to a combined statistical analysis (meta-analysis) regarding the influence of study design factors upon reported headache and total symptom incidences after lumbar iohexol myelography. " 01/01/1990 - "Two patients (5%) of each group experienced noted unpleasant taste, and two patients (5%) of the iohexol group complained of headache. " 01/01/1989 - "The results supports the hypothesis that CSF leakage is a major cause of headache after lumbar iohexol myelography." 01/01/1987 - "These results suggest that apart from the slight early-onset headache, most side effects after lumbar iohexol myelography are related to the puncture per se, not to the contrast agent."

Related Drugs and Biologics

1.	Creatinine
2.	Contrast Media
3.	Iohexol (Omnipaque)
4.	Iodine
5.	Diatrizoate (Hypaque)
6.	Inulin
7.	Metrizamide
8.	Iopamidol (Isovue)
9.	iodixanol (Visipaque)
10.	iotrolan (Isovist)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Transplants (Transplant)
3.	Intravenous Injections
4.	Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)
5.	Aftercare (After-Treatment)