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Clioquinol (Vioform)

A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.

Also Known As:

Vioform; 5-Chloro-7-iodo-8-quinolinol; Chinoform; Entero-Septol; Entero-Vioform; Enteroquinol; 5 Chloro 7 iodo 8 quinolinol; Entero Septol; Entero Vioform; EnteroSeptol; EnteroVioform; Chloroiodoquine; Iodochlorhydroxyquin; Iodochloroxyquinoline; 8-Quinolinol, 5-chloro-7-iodo-

Networked: 223 relevant articles (14 outcomes, 41 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ding, Wei-Qun: 9 articles (12/2011 - 04/2005)
2.	Bush, Ashley I: 6 articles (09/2015 - 11/2002)
3.	Lind, Stuart E: 6 articles (12/2011 - 04/2005)
4.	Dou, Q Ping: 6 articles (02/2010 - 01/2005)
5.	Volitakis, Irene: 5 articles (09/2015 - 12/2003)
6.	Chen, Di: 5 articles (09/2009 - 01/2005)
7.	Mao, Xinliang: 4 articles (01/2014 - 11/2008)
8.	Yu, Haijun: 4 articles (09/2011 - 01/2009)
9.	Tanzi, Rudolph E: 4 articles (07/2008 - 11/2002)
10.	Masters, Colin L: 4 articles (07/2008 - 12/2003)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2006 - "To evaluate the efficacy of clioquinol for the treatment of cognitive impairment due to Alzheimer's disease. " 01/01/2008 - "The Internet was searched using the term: clioquinol, PBT, MPAC Randomised double-blind trials in which treatment with clioquinol was administered to participants with Alzheimer's disease in parallel group comparison with placebo are included. " 05/01/2007 - "Successful trials with 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, CQ) for Alzheimer's disease treatment prompted renewed interest in assessing whether its therapeutic action is related to the coordination of neurotoxic trace metals, such as Cu(II) and Zn(II). " 01/01/2006 - "Randomised double-blind trials in which treatment with clioquinol was administered to participants with Alzheimer's disease in parallel group comparison with placebo are included. " 01/01/2005 - "PBT-1 (clioquinol), is undergoing phase II clinical trials by Prana Biotechnology Ltd for the potential treatment of Alzheimer's disease. "
2.	Neoplasms (Cancer) 12/15/2011 - "The present study compared the cytotoxicity of clioquinol with six analogues using human cancer cell lines. " 09/01/2011 - "This study demonstrates for the first time that clioquinol targets post-transcriptional steps of cyclin D1 gene expression in cancer cells, adding new insight into our understanding of its mechanisms of anticancer action." 03/01/2011 - "Given the prior toxicology and pharmacology studies, Clioquinol could be rapidly repositioned for a new anti-cancer indication. " 11/10/2008 - "Such information will aid in the design of clinical trials of oral Clioquinol for new indications such as cancer therapy." 11/13/2014 - "The complexes were also >100-fold more potent than clioquinol in a tumor spheroid model, with values similar to currently used chemotherapeutics for the treatment of solid tumors. "
3.	Skin Diseases 05/19/1983 - "[Report of experiences with the effect of Linola-Vioform in various dermatoses]." 03/01/1967 - "Treatment of inflammatory dermatoses with a corticosteroid-clioquinol paste." 01/01/1958 - "Bradex-vioform in the treatment of fungus and other skin diseases." 06/21/1957 - "[The use of bradex-vioform in various skin diseases]." 04/24/1953 - "[Bradex and bradex-vioform in therapy of mycotic and bacterial dermatoses]."
4.	Infection 12/01/1978 - "A double-blind multicenter study compared the antifungal effectiveness of an iodochlorhydroxyquin-hydrocoritsone cream with that of its individual components in 354 patients with cutaneous fungal infections. " 01/01/2015 - "Despite clinical features mimicking infection or multiple sclerosis, SMON was confirmed as being caused by ingestion of clioquinol, an intestinal antibacterial drug, based on extensive epidemiological studies. " 07/14/2009 - "Effects of clioquinol on memory impairment and the neurochemical modifications induced by scrapie infection in golden hamsters." 01/01/1987 - "Our studies demonstrate the efficacy of prophylactic tetracycline but do not support the use of clioquinol to prevent intestinal infection due to these organisms. " 01/01/1987 - "Comparison of prophylactic tetracycline and clioquinol in a rabbit model of intestinal infection with Vibrio cholerae and Escherichia coli."
5.	Dementia (Dementias) 01/01/2014 - "We searched ALOIS, the Cochrane Dementia and Cognitive Improvement Group Specialized Register, on 29 July 2010 using the terms: Clioquinol OR PBT1 OR PBT2 OR "metal protein" OR MPACS OR MPAC. " 01/01/2012 - "We searched ALOIS, the Cochrane Dementia and Cognitive Improvement Group Specialized Register, on 29 July 2010 using the terms: Clioquinol OR PBT1 OR PBT2 OR "metal protein" OR MPACS OR MPAC. " 01/01/2008 - "The Cochrane Dementia and Cognitive Improvement Group's Specialized Register was searched on 15 February 2007 using the terms clioquinol, PBT, MPAC. " 01/01/2006 - "The Cochrane Dementia and Cognitive Improvement Group's Specialized Register was searched on 20 May 2005 using the terms clioquinol and PBT1. " 09/01/2015 - "Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse."

Related Drugs and Biologics

1.	Copper
2.	Tetracycline (Achromycin)
3.	Clioquinol (Vioform)
4.	Zinc
5.	Ligands
6.	Gentamicins (Gentamicin)
7.	Tolnaftate (Ting)
8.	Diflucortolone
9.	Betamethasone 17-Valerate (Betamethasone 17 Valerate)
10.	secnidazole

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Oral Administration
4.	Transplants (Transplant)
5.	Synchrotrons