Iodine

A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.

Networked: 8924 relevant articles (363 outcomes, 989 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zimmermann, Michael B: 39 articles (09/2015 - 01/2002)
2.	Laurberg, Peter: 35 articles (02/2016 - 01/2002)
3.	Tuttle, R Michael: 33 articles (12/2015 - 11/2002)
4.	Teng, Weiping: 28 articles (11/2015 - 05/2002)
5.	Knudsen, Nils: 26 articles (11/2015 - 02/2002)
6.	Shan, Zhongyan: 24 articles (11/2015 - 05/2002)
7.	Ovesen, Lars: 24 articles (11/2015 - 02/2002)
8.	Pearce, Elizabeth N: 24 articles (10/2015 - 12/2002)
9.	Perrild, Hans: 23 articles (11/2015 - 02/2002)
10.	Braverman, Lewis E: 23 articles (05/2015 - 12/2002)

Related Diseases

1.	Thyroid Neoplasms (Thyroid Cancer) 11/15/2012 - "It cannot be ruled out that iodine supplementation may play a role for the risk of thyroid cancer, but as the strongest increase in incidence began in the years before the implementation, it is likely that improvement in diagnostic modalities increased diagnostic activity, and/or new unknown risk factors are also important contributors to the increase." 01/01/2012 - "The vast majority of patients with differentiated thyroid cancer (DTC) are treated successfully with surgery and radioactive iodine ablation, yet the treatment of advanced cases is frustrating and largely ineffective. " 10/01/2015 - "To improve the efficacy of radioactive iodine (RAI) therapy for differentiated thyroid cancer patients, a low-iodine diet (LID) prior to the therapy is recommended. " 01/01/2014 - "Overall, this suggests that the use of AMPK modulating compounds may be useful for the enhancement of iodide uptake by thyrocytes, which could be useful for the treatment of thyroid cancer patients with radioactive iodine." 05/01/2006 - "Trials evaluating the efficacy of cytotoxic chemotherapeutic agents in iodine-refractory thyroid carcinoma and current novel therapeutic approaches will be emphasized."
2.	Neoplasms (Cancer) 06/01/2005 - "Residualizing iodine markedly improved tumor targeting using bispecific antibody-based pretargeting." 06/01/2014 - "Biodistribution of 125I/111In-capromab showed a more rapid clearance of iodine radioactivity from liver, spleen, kidneys, bones, colon tissue, as well as tumors. " 01/01/2012 - "To determine the efficacy of early screening, using endoscopy with iodine staining or cytologic examination, in reducing mortality from oesophageal cancer in asymptomatic individuals from high-risk and general populations. " 02/01/2008 - "Surgery followed by radioactive iodine ablation is the mainstay of treatment for differentiated thyroid cancers, and the majority of patients can expect high cure rates." 12/01/2001 - "The combination of RA and PA may be beneficial in the treatment of advanced thyroid cancers for which conventional therapy fails or as an adjuvant to radioactive iodine therapy in aggressive tumors."
3.	Hyperthyroidism 02/01/2006 - "Radioactive iodine provides a simple, effective, and safe treatment for cats with hyperthyroidism and is regarded by most authorities to be the treatment of choice. " 07/01/1999 - "In cases of iodine-related hyperthyroidism the concept of early and radical surgical treatment, following stabilization of the patient in a reasonably short amount of time shows best results and is thus favored. " 06/01/2008 - "The increase in remnant thyroid tissue radioactive iodine uptake was significantly greater in the patients operated upon for hyperthyroidism compared with those operated upon for nontoxic multinodular goitre (p = 0.0001). " 12/01/2007 - "Treatment with inorganic iodine for 7 months successfully relieved all symptoms of hyperthyroidism in both patients." 12/01/2003 - "Radioactive iodine was found to be a safe and an effective treatment for hyperthyroidism in Nigerian patients, but a high rate of default precludes adequate long-term follow-up."
4.	Goiter 01/01/2000 - "Goiter rates and iodine deficiency usually show marked improvement in efficacy studies of mandatory iodization of salt, but little is known about the short-term effectiveness of mandatory iodization. " 08/01/1986 - "Iodination of the water was followed by a prompt and marked reduction in goiter prevalence, and by improvement in biochemical indices of iodine deficiency. " 08/01/2004 - "Despite good results of iodine treatment of non-toxic goiters, this case describes an unintended outcome leaving a patient without thyroid tissue, and a protracted course could have been avoided if the patient had undergone surgery earlier. " 07/01/1999 - "After promote iodinated-food consumption, good results with a decrease in goiter prevalence and a increase in urinary iodine excretion were observed. " 01/01/1996 - "There was a small but significant reduction in serum T3, FT3I as well as in the prevalence and severity of goiter 1 year following iodine treatment. "
5.	Hypothyroidism 05/01/2011 - "Placental iodine content was only ∼3% that of the thyroid, but on the basis that neonatal iodine stores are very low and highly sensitive to fluctuations in maternal iodine supply, we postulate that placental iodine bioavailability makes a significant contribution to protection against neonatal hypothyroidism. " 01/01/1998 - "Iodine prophylaxis is highly effective in preventing the development of iodine deficiency disorders including transient neonatal hypothyroidism. " 01/01/1994 - "Iodine prophylaxis is highly effective in preventing the development of iodine deficiency disorders including transient neonatal hypothyroidism. " 01/01/2009 - "Dietary iodine supplementation alone resulted in complete remission of IDD in the subjects, including the 2 patients with hypothyroidism. " 07/01/1995 - "Since the clearance of iodine is linearly related to GFR, our study suggests that in the setting of hypothyroidism, the bioavailability of a given dose of radioiodine may have significant individual variation."

Related Drugs and Biologics

1.	Thyroglobulin
2.	Iron
3.	iodized salt (iodised salt)
4.	Thyroxine (Levothyroxine)
5.	Antithyroid Agents (Antithyroid Drugs)
6.	Amiodarone (Amiodarona)
7.	Contrast Media
8.	Bromine
9.	Starch (Cornstarch)
10.	Triiodothyronine (Liothyronine)

Related Therapies and Procedures

1.	Thyroidectomy
2.	Brachytherapy
3.	Radiotherapy
4.	Drug Therapy (Chemotherapy)
5.	Baths