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Iodide Peroxidase (Deiodinase)

Subscribe to New Research on Iodide Peroxidase

A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. EC 1.11.1.8.

Also Known As:

Deiodinase; Thyroid Peroxidase; Iodothyronine Deiodinase; Tetraiodothyronine 5' Deiodinase; Thyroxine 5' Deiodinase; 5'-Deiodinase; Iodotyrosine Deiodinase; Monodeiodinase; Reverse Triiodothyronine 5'-Deiodinase; T4-5'-Deiodinase; T4-Monodeiodinase; Tetraiodothyronine 5'-Deiodinase; Thyroxine Converting Enzyme; Triiodothyronine Deiodinase; 5' Deiodinase; 5'-Deiodinase, Iodothyronine; 5'-Deiodinase, Reverse Triiodothyronine; 5'-Deiodinase, Tetraiodothyronine; 5'-Deiodinase, Thyroxine; 5'-Monodeiodinase, Thyroxine; Deiodase, Iodotyrosine; Deiodinase, Iodothyronine; Deiodinase, Iodotyrosine; Deiodinase, Triiodothyronine; Enzyme, Thyroxine Converting; Iodothyronine 5' Deiodinase; Peroxidase, Iodide; Peroxidase, Thyroid; Reverse Triiodothyronine 5' Deiodinase; T4 5' Deiodinase; T4 Monodeiodinase; Thyroxine 5' Monodeiodinase; Triiodothyronine 5'-Deiodinase, Reverse; Iodinase; Iodothyronine 5'-Deiodinase; Iodotyrosine Deiodase; Thyroxine 5'-Deiodinase; Thyroxine 5'-Monodeiodinase; Iodide:hydrogen-peroxide oxidoreductase

Networked: 1051 relevant articles (15 outcomes, 98 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - Peroxidases: 186
      - Iodide Peroxidase: 1051
        iodothyronine deiodinase type II: 15
        iodothyronine deiodinase type I: 14
        iodothyronine deiodinase type III: 3
        human TPO protein
        mouse selenodeiodinase type 1
        vanadium iodoperoxidase

Experts

1.	Visser, Theo J: 18 articles (02/2014 - 07/2002)
2.	Bianco, Antonio C: 13 articles (11/2015 - 03/2005)
3.	Van den Berghe, Greet: 11 articles (10/2014 - 07/2003)
4.	Peeters, Robin P: 10 articles (10/2015 - 07/2003)
5.	Salvatore, Domenico: 10 articles (02/2015 - 10/2002)
6.	Huang, Stephen A: 10 articles (04/2014 - 10/2002)
7.	Visser, T J: 10 articles (05/2013 - 02/2000)
8.	Larsen, P Reed: 8 articles (02/2015 - 10/2002)
9.	Zavacki, Ann Marie: 8 articles (02/2015 - 03/2005)
10.	Fliers, Eric: 8 articles (03/2014 - 06/2006)

Related Diseases

1.	Hypothyroidism 11/01/2014 - "Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism." 03/01/1973 - "[Hormonal and metabolic studies in a case of athyreotic hypothyroidism with secondary hypoactivity of deiodinase]." 03/01/2015 - "A common polymorphism in the gene encoding the activating deiodinase (Thr92Ala-D2) is known to be associated with quality of life in millions of patients with hypothyroidism and with several organ-specific conditions. " 01/01/2015 - "High Body Mass Index Is an Indicator of Maternal Hypothyroidism, Hypothyroxinemia, and Thyroid-Peroxidase Antibody Positivity during Early Pregnancy." 11/01/2014 - "In conclusion, the Hedgehog-dependent changes in liver stromal cells drive repair-related changes in hepatic deiodinase expression that promote intrahepatic hypothyroidism, thereby limiting exposure to T3, an important factor for cellular differentiation."
2.	Thyroiditis 06/01/2003 - "No such studies, however, have been performed for thyroid peroxidase (TPO), the major autoantigen in human thyroiditis. " 05/01/2012 - "Thyroid peroxidase antibody positivity is associated with symptomatic distress in patients with Hashimoto's thyroiditis." 07/01/2011 - "This action, which correlates with a reduction in thyroid peroxidase antibody titers, may be associated with clinical benefits in the prevention and management of Hashimoto's thyroiditis, particularly in subjects receiving both agents." 01/01/2010 - "Biochemical testing of thyroid function and Thyroid Peroxidase Antibody was in-keeping with an associated Hashimoto's thyroiditis. " 09/01/2009 - "Grading of thyroiditis and lymphocytic infiltration showed no correlation with the clinical severity of HT, while a high L:E ratio was strongly correlated with thyroid peroxidase positivity (p = 0.004). "
3.	Graves Disease (Basedow Disease) 01/01/2012 - "Thr92Ala polymorphism of human type 2 deiodinase gene (hD2) affects the development of Graves' disease, treatment efficiency, and rate of remission." 10/01/2015 - "The association of thyroid peroxidase antibody risk loci with susceptibility to and phenotype of Graves' disease." 08/15/2009 - "Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease." 02/01/2003 - "Pax-8 expression correlates with type II 5' deiodinase expression in thyroids from patients with Graves' disease." 01/01/2001 - "Forty-one single-chain variable region fragments (scFvs) directed against thyroid peroxidase (TPO) were obtained by phage display libraries constructed from thyroid-infiltrating B cells of Graves' disease patients. "
4.	Adenoma (Adenomas) 05/01/1987 - "Ultrastructural localization of endogenous thyroid peroxidase under benign pathological conditions such as toxic diffuse goiter, non-toxic multinodular goiter, and adenoma, and in normal tissue was studied. " 03/01/2006 - "The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma." 06/01/2002 - "Thyroid hormone receptors and type I iodothyronine 5'-deiodinase activity of human thyroid toxic adenomas and benign cold nodules." 08/01/2002 - "We examined 5'-deiodinase enzyme activities in pituitary adenomas (18 non-functioning, seven TSH-producing, one GH- and TSH-producing, five GH-producing, eight prolactin (PRL)-producing, two adenomas each from patients with Cushing's disease and Nelson's syndrome) and three normal anterior pituitaries. " 05/01/1994 - "Thyroid peroxidase was expressed intensely not only in tissues from Graves disease and hyperfunctioning adenomas, but also in those from carcinomas, adenomas and Hashimoto's thyroiditis. "
5.	Body Weight (Weight, Body) 08/01/1986 - "To study the effect of rT3 on the 5'-deiodinase type II (5'D-II) of rat brain cortex and anterior pituitary, daily infusions of rT3 at rates of 0.5, 1.5, 4.5, and 13.5 nmol/day X 100 g body weight were given to a total of 87 hypothyroid rats. " 09/01/1993 - "Intestinal 5'deiodinase activity (5'D) in adults from lines of chickens selected for high (HW) and low (LW) juvenile body weight was studied in vitro using reverse T3 substrate. " 09/01/1993 - "Intestinal 5'deiodinase activity of developing and adult chickens selected for high and low body weight." 07/01/2007 - "It was found that the deterioration of diabetic animals occurs in different terms after irradiation exposure, resulting in considerable body weight decrease, well-marked hyperglycemia, abrupt falling of leukocytic system parameters, intensification energetic processes of extant lymphocytes, imbalance of lipid metabolism and thyroid state, as well as significant inhibition of 5'-deiodinase activity in liver tissue." 01/01/2015 - "Analyses of hepatic TH target genes involved in lipid metabolism revealed T3-like changes in gene expression and increased type I-deiodinase activity after application of 3,5-T2 (2.5 μg/g body weight). "

Related Drugs and Biologics

1.	Antibodies
2.	Thyroglobulin
3.	Autoantibodies
4.	Thyroxine (Levothyroxine)
5.	Thyrotropin (Thyroid-Stimulating Hormone)
6.	Messenger RNA (mRNA)
7.	Thyrotropin Receptors (Thyrotropin Receptor)
8.	Iodine
9.	Propylthiouracil
10.	papillary Thyroid cancer

Related Therapies and Procedures

1.	Thyroidectomy
2.	Low-Level Laser Therapy (LLLT)
3.	Aftercare (After-Treatment)
4.	Drug Therapy (Chemotherapy)
5.	Transplants (Transplant)