Chromosome Inversion (Chromosomal Inversion)

An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.

Also Known As:

Networked: 105 relevant articles (0 outcomes, 5 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Isochromosomes
2.	Chromosome Aberrations (Chromosome Abnormalities)
3.	Genetic Translocation (Chromosomal Translocation)
4.	Malaria
5.	Lymphoma (Lymphomas)

Experts

1.	Ruiz, Alfredo: 6 articles (06/2014 - 04/2005)
2.	Marzo, Mar: 3 articles (08/2013 - 02/2008)
3.	Puig, Marta: 3 articles (01/2013 - 02/2008)
4.	Besansky, Nora J: 3 articles (01/2012 - 07/2006)
5.	Costantini, Carlo: 3 articles (01/2012 - 07/2006)
6.	Kurbalija Novičić, Zorana: 2 articles (01/2015 - 03/2012)
7.	Kenig, Bojan: 2 articles (01/2015 - 03/2012)
8.	Mano, Hiroyuki: 2 articles (01/2015 - 12/2008)
9.	Stamenković-Radak, Marina: 2 articles (01/2015 - 03/2012)
10.	Delprat, Alejandra: 2 articles (06/2014 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chromosome Inversion:

1.	DNA (Deoxyribonucleic Acid)IBA 11/01/2009 - "Our study also indicated that genomic DNA alternations (involving chromosome inversion, sequence loss and gene translocation) contributed to the genomic discrepancies between salt cress and Arabidopsis." 11/01/2012 - "In addition to deletions, we obtained chromosomal inversions ranging in size from less than 10 kb (within the transgene DNA) to over 1 million base pairs (Mb). " 06/01/2009 - "Furthermore, close examination of sequences flanking DNA duplications and those found at the breakpoints of chromosomal inversions suggests a connection between these two events. " 12/01/2006 - "The pKZ1 chromosomal inversion assay is a sensitive assay for studying the effects of DNA damaging agents using chromosomal inversion as a mutation end-point. " 01/01/2006 - "Non-linear dose response curves for chromosomal inversion as an end-point have been identified at low doses of DNA damaging agents using this assay. "
2.	IsoenzymesIBA 01/01/2013 - "Earlier studies using chromosome inversions, isoenzymes and a number of molecular markers have suggested that An. cruzii is a species complex. " 02/01/1995 - "XXXII. Linkage disequilibrium between allozymes and chromosome inversions in two colonizing populations." 11/01/1987 - "In the past, a number of worldwide populations of Drosophila melanogaster have been extensively studied for several such markers, including allozymes, chromosomal inversions, and quantitative characters. " 11/01/1994 - "In addition, hypothesized phylogenetic relationships of these three semispecies, based on our mtDNA data, are identical to those based on allozymes and chromosomal inversions. " 11/30/1987 - "Observations on the extent and temporal stability of latitudinal clines for alcohol dehydrogenase allozymes and four chromosome inversions in Drosophila melanogaster."
3.	Mitochondrial DNA (mtDNA)IBA 03/01/2012 - "To investigate the role of cytonuclear interactions in shaping mitochondrial DNA variability in natural populations of this species, the study was complemented with the analysis of linkage disequilibria between mitochondrial haplotypes and chromosomal inversion arrangements. " 01/01/2011 - "We summarized CHC variation using CDF analysis and mapped the first five CHC canonical variates (CVs) onto an independently derived period (per) gene + chromosome inversion + mtDNA COI gene for each sex. " 04/01/2009 - "Here, we investigate the genetic structure of eight geographical populations within and around the Nile Delta using mitochondrial DNA sequences of the cox2 gene and chromosomal inversion polymorphism. " 07/01/2006 - "Sampling across an approximately 300-km east-west transect largely contained within the Sudan-Savanna ecoclimatic zone, we analyzed chromosomal inversions, 16 microsatellite loci distributed genomewide, and 834 bp of the mtDNA ND5 gene. " 11/01/1994 - "In addition, hypothesized phylogenetic relationships of these three semispecies, based on our mtDNA data, are identical to those based on allozymes and chromosomal inversions. "
4.	Factor VIII (Coagulation Factor VIII)IBA 04/01/2004 - "In this study, neither the prevalence of inhibitor development against factor VIII nor the frequency of sporadic cases in the group presenting gene inversions was significantly different from that in the group without chromosomal inversions. " 08/06/2015 - "Hemophilia A is an X-linked genetic disorder caused by mutations in the F8 gene, which encodes the blood coagulation factor VIII. Almost half of all severe hemophilia A cases result from two gross (140-kbp or 600-kbp) chromosomal inversions that involve introns 1 and 22 of the F8 gene, respectively. " 08/06/2015 - "Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9."
5.	ChromatinIBA 01/01/2014 - "In this study we evaluated the effect of linear energy transfer (LET) and chromatin structure on the induction of chromosomal inversion. " 01/01/2014 - "Role of LET and chromatin structure on chromosomal inversion in CHO10B2 cells." 06/01/2004 - "The observation of a lagging bivalent, a bridge of chromatin, or two aligned laggards in the aposporous parent suggested a chromosome inversion in this strain. "
6.	DNA Transposable Elements (Element, IS)IBA 06/01/2014 - "Herein, we show that Tetris shares the final portions of its terminal inverted repeats (TIRs) with DAIBAM, a previously described miniature inverted transposable element implicated in the generation of chromosome inversions. " 01/01/2013 - " Galileo is a transposable element responsible for the generation of three chromosomal inversions in natural populations of Drosophila buzzatii. " 01/01/2011 - "An overall strong structural conservation was observed, with the exception of three isolated regions of disturbed collinearity: (1) a local invasion of transposable elements around a putative F-box gene within S(1), (2) the multiple duplication and subsequent divergence of the same F-box gene within S(1)A, (3) an interspecific chromosomal inversion in S(1)B, which restricts recombination in our O. " 02/26/2008 - "Galileo is the only transposable element (TE) known to have generated natural chromosomal inversions in the genus Drosophila. " 03/01/2007 - "Ectopic exchange between transposable elements or other repetitive sequences along a chromosome can produce chromosomal inversions. "
7.	Carbon MonoxideIBA 01/01/2012 - "Chromosomal inversions are thought to confer a selective advantage in alternative habitats by protecting co-adapted alleles from recombination. " 01/01/2003 - "This again indicates the existence of supergene selection as another mechanism for protection of chromosomal inversions, as co-adapted complexes in natural D. " 01/01/2003 - "An epistasis of lethal genes present in O-inversion hetero- and not present in O-inversion homokaryotypes of moderate or low frequencies could be good example for co-adaptation of chromosomal inversions with regard to the genetic load. " 03/24/2000 - "A model is presented which predicts that co-evolution is achieved by gene conversions and chromosomal inversions. " 03/24/2000 - "Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions."
8.	T-Cell Antigen Receptors (T-Cell Receptor)IBA 12/01/1993 - "Rearrangement by chromosomal inversion in the T cell receptor gamma locus in a murine alpha beta T cell clone." 01/02/1986 - "These data demonstrate for the first time a linkage between mammalian V and C genes and verify that a functional T-cell receptor V beta gene can be constructed through a chromosomal inversion." 01/02/1986 - "Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements." 10/15/1987 - "Our observation and other reported findings suggest that the rearrangement of chromosome 14 at break band q11 is specific for lymphoma-type or acute-type ATL patients, and aberrations of proto-oncogene expression or the coding sequence by recombination involving a T-cell antigen receptor gene due to chromosome inversion or chromosome translocation may play an important role in T-cell neoplasia including ATL." 10/01/1992 - "Immunoglobulin VH-T cell receptor C alpha fusion mRNA resulting from chromosome inversion include the T cell-associated 5' exon ET."
9.	HeterochromatinIBA 01/01/2015 - "The low SNP-frequency regions overlay heterochromatin and chromosome inversion domains, consistent with the lower recombinant rates at these regions. " 01/01/2009 - "white-mottled X-chromosomal inversions in Drosophila are classic PEV models that show variegation of the eye color gene white due to its relocation next to pericentric heterochromatin. " 07/01/2007 - "Pericentric chromosome inversion 9phqh was not characteristic of patients with autism, while variation in heterochromatin regions 1phqh, 9qh+, and 16qh-were found significantly more frequently in children with autism. " 04/01/2007 - "The legacy of this conflict could include the unexpectedly rapid evolution of nuclear transport-related proteins, the accumulation of chromosomal inversions, the recruitment of gene duplications, and the turnover of repetitive sequences in the centric heterochromatin."
10.	Phosphotransferases (Kinase)IBA 01/01/2015 - "A small chromosomal inversion thus leads to fusion of the amino-terminal portion of the microtubule-associated protein EML4 to the intracellular kinase domain of ALK, a receptor-type protein tyrosine kinase. " 04/15/2009 - "The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene resulting from the chromosome inversion inv(2)(p21;p23) recently was identified in nonsmall cell lung cancer (NSCLC). " 09/01/1999 - "During the last year the expression of anaplastic lymphoma kinase clarified presentation and provided clues toward the outcome of anaplastic large cell lymphoma; the breakpoints of t(2;5) were mapped; constitutive activation of anaplastic lymphoma kinase by a chromosomal inversion was described; transformation was shown to be independent of nuclear localization of anaplastic lymphoma kinase; and phospholipase C-gamma was identified as a molecular target for the kinase activity of anaplastic lymphoma kinase. "