Chromosome Inversion (Chromosomal Inversion)

An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.

Also Known As:

Networked: 176 relevant articles (0 outcomes, 9 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Malaria
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
3.	Genetic Translocation (Chromosomal Translocation)
4.	Neoplasms (Cancer)
5.	Lymphoma (Lymphomas)

Experts

1.	Ruiz, Alfredo: 8 articles (01/2019 - 04/2005)
2.	Mano, Hiroyuki: 3 articles (03/2021 - 12/2008)
3.	Aguadé, Montserrat: 3 articles (01/2020 - 08/2008)
4.	Besansky, Nora J: 3 articles (12/2016 - 07/2006)
5.	Delprat, Alejandra: 3 articles (05/2014 - 11/2009)
6.	Marzo, Mar: 3 articles (08/2013 - 02/2008)
7.	Puig, Marta: 3 articles (02/2013 - 02/2008)
8.	Kamau, Luna: 2 articles (12/2021 - 10/2016)
9.	Matoke-Muhia, Damaris: 2 articles (12/2021 - 10/2016)
10.	Peterson, Thomas: 2 articles (01/2021 - 11/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chromosome Inversion:

1.	DNA (Deoxyribonucleic Acid)IBA 01/01/2023 - "Further modification of the genome composition can be induced by chromosomal inversion events which lead to relocation of genes in the affected genomic DNA segments, modify the otherwise highly conserved core genome synteny and could even alter the location of the replication terminus. " 12/01/2018 - "Based on RAD (restriction site associated DNA) sequencing, we analysed SNPs and chromosome inversions in populations in Denmark and Greenland showing low and high parallelism, respectively. " 01/01/2017 - "The chromosomal inversion was present in four of these and in seven the deletion extended beyond the inversion into adjacent chromosomal DNA. " 01/01/2016 - "The in vivo mouse transgenic pKZ1 chromosomal inversion assay is a sensitive assay that responds to very low doses of DNA-damaging agents. " 11/01/2012 - "In addition to deletions, we obtained chromosomal inversions ranging in size from less than 10 kb (within the transgene DNA) to over 1 million base pairs (Mb). "
2.	IsoenzymesIBA 09/24/2013 - "Earlier studies using chromosome inversions, isoenzymes and a number of molecular markers have suggested that An. cruzii is a species complex. " 02/01/2023 - "An allozyme polymorphism is associated with a large chromosomal inversion in the marine snail Littorina fabalis." 05/01/2008 - "Drosophila melanogaster shows clinal variation along latitudinal transects on multiple continents for several phenotypes, allozyme variants, sequence variants, and chromosome inversions. " 04/01/2003 - "Allozyme loci are frequently found non randomly associated to the chromosomal inversions in which they are included in Drosophila. " 04/01/2003 - "Seasonal cycles of allozyme-by-chromosomal-inversion gametic disequilibrium in Drosophila subobscura."
3.	Mitochondrial DNA (mtDNA)IBA 03/01/2012 - "To investigate the role of cytonuclear interactions in shaping mitochondrial DNA variability in natural populations of this species, the study was complemented with the analysis of linkage disequilibria between mitochondrial haplotypes and chromosomal inversion arrangements. " 06/23/2011 - "We summarized CHC variation using CDF analysis and mapped the first five CHC canonical variates (CVs) onto an independently derived period (per) gene + chromosome inversion + mtDNA COI gene for each sex. " 04/01/2009 - "Here, we investigate the genetic structure of eight geographical populations within and around the Nile Delta using mitochondrial DNA sequences of the cox2 gene and chromosomal inversion polymorphism. " 07/01/2006 - "Sampling across an approximately 300-km east-west transect largely contained within the Sudan-Savanna ecoclimatic zone, we analyzed chromosomal inversions, 16 microsatellite loci distributed genomewide, and 834 bp of the mtDNA ND5 gene. " 11/01/1994 - "In addition, hypothesized phylogenetic relationships of these three semispecies, based on our mtDNA data, are identical to those based on allozymes and chromosomal inversions. "
4.	Pyrethrins (Pyrethroids)FDA Link 06/10/2021 - "2La Paracentric Chromosomal Inversion and Overexpressed Metabolic Genes Enhance Thermotolerance and Pyrethroid Resistance in the Major Malaria Vector Anopheles gambiae." 05/01/2023 - "During deltamethrin selections, the 2La chromosomal inversion rose in frequency (from 33% to 86%), supporting a previous link with pyrethroid resistance. " 12/13/2021 - "The knockdown resistance (kdr) mutation associated with resistance to DDT and pyrethroids, the acetylcholinesterase-1 (ace-1R) mutation associated with resistance to organophosphates and carbamates and 2La chromosomal inversion associated with indoor resting behaviour, were investigated in the present study. "
5.	DDTIBA 06/01/1995 - "Association of DDT resistance levels with chromosome inversion polymorphism was investigated in Anopheles arabiensis samples collected from southwestern Ethiopia. " 07/01/1995 - "Differential responses of the mosquitoes Anopheles arabiensis and An. gambiae sensu stricto to house-spraying with DDT or lambda-cyhalothrin were evaluated in relation to chromosomal inversion polymorphism, feeding and resting behaviour of these malaria vectors in Tanzania. " 12/13/2021 - "The knockdown resistance (kdr) mutation associated with resistance to DDT and pyrethroids, the acetylcholinesterase-1 (ace-1R) mutation associated with resistance to organophosphates and carbamates and 2La chromosomal inversion associated with indoor resting behaviour, were investigated in the present study. "
6.	ChromatinIBA 01/28/2014 - "In this study we evaluated the effect of linear energy transfer (LET) and chromatin structure on the induction of chromosomal inversion. " 01/01/2018 - "Finally, the presence of chromatin bridges indicates the indirect occurrence of chromosomal inversions, although chromosome fragments were not clearly recognized. " 01/28/2014 - "Role of LET and chromatin structure on chromosomal inversion in CHO10B2 cells." 06/01/2004 - "The observation of a lagging bivalent, a bridge of chromatin, or two aligned laggards in the aposporous parent suggested a chromosome inversion in this strain. "
7.	Factor VIII (Coagulation Factor VIII)IBA 04/01/2004 - "In this study, neither the prevalence of inhibitor development against factor VIII nor the frequency of sporadic cases in the group presenting gene inversions was significantly different from that in the group without chromosomal inversions. " 08/06/2015 - "Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9." 08/06/2015 - "Hemophilia A is an X-linked genetic disorder caused by mutations in the F8 gene, which encodes the blood coagulation factor VIII. Almost half of all severe hemophilia A cases result from two gross (140-kbp or 600-kbp) chromosomal inversions that involve introns 1 and 22 of the F8 gene, respectively. "
8.	Complement System Proteins (Complement)IBA 12/01/2016 - "Here, we study an ecologically diversifying lineage of Anopheles gambiae, known as the Bamako chromosomal form based on its unique complement of three chromosomal inversions, to explore the impact of these inversions on ecotypic differentiation. " 11/10/2008 - "In the Anopheles gambiae complex, paracentric chromosomal inversions are non-randomly distributed along the complement: 18/31 (58%) of common polymorphic inversions are on chromosome arm 2R, which represents only approximately 30% of the complement. "
9.	SaltsIBA 11/01/2009 - "Our study also indicated that genomic DNA alternations (involving chromosome inversion, sequence loss and gene translocation) contributed to the genomic discrepancies between salt cress and Arabidopsis."
10.	OrganophosphatesIBA 12/13/2021 - "The knockdown resistance (kdr) mutation associated with resistance to DDT and pyrethroids, the acetylcholinesterase-1 (ace-1R) mutation associated with resistance to organophosphates and carbamates and 2La chromosomal inversion associated with indoor resting behaviour, were investigated in the present study. "

Therapies and Procedures

1.	Insecticide-Treated Bednets 10/01/2016 - "Decline in frequency of the 2La chromosomal inversion in Anopheles gambiae (s.s.) in Western Kenya: correlation with increase in ownership of insecticide-treated bed nets."
2.	Nuclear Power Plants 01/01/2018 - "Frequencies of chromosomal inversions in Drosophila melanogaster in Fukushima after the nuclear power plant accident." 01/01/2018 - "In order to investigate genetic impact of a large amount of radionuclides released by the Fukushima Dai-ichi Nuclear Power Plant accident in 2011, we surveyed 2,304 haploid genomes of Drosophila melanogaster collected in three localities in Fukushima in 2012 and 2013 for chromosomal inversions. "