Intussusception

A form of intestinal obstruction caused by the PROLAPSE of a part of the intestine into the adjoining intestinal lumen. There are four types: colic, involving segments of the LARGE INTESTINE; enteric, involving only the SMALL INTESTINE; ileocecal, in which the ILEOCECAL VALVE prolapses into the CECUM, drawing the ILEUM along with it; and ileocolic, in which the ileum prolapses through the ileocecal valve into the COLON.

Also Known As:

Networked: 1445 relevant articles (51 outcomes, 124 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Gastroenteritis
2.	Peritonitis
3.	Intussusception
4.	Neoplasms (Cancer)
5.	Intestinal Obstruction (Obstruction, Intestinal)

Experts

1.	Parashar, Umesh D: 19 articles (12/2015 - 09/2005)
2.	Bines, Julie E: 10 articles (02/2015 - 11/2004)
3.	Vesikari, Timo: 9 articles (08/2015 - 01/2006)
4.	Tate, Jacqueline E: 7 articles (12/2015 - 04/2012)
5.	Nakagomi, Osamu: 7 articles (11/2013 - 08/2005)
6.	Patel, Manish: 6 articles (11/2014 - 06/2008)
7.	Baggs, James: 6 articles (02/2014 - 06/2008)
8.	Patel, Manish M: 6 articles (01/2013 - 05/2009)
9.	Cortese, Margaret M: 5 articles (12/2015 - 11/2009)
10.	Djonov, Valentin: 5 articles (12/2014 - 05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intussusception:

1.	BariumIBA 01/01/2000 - "While there is agreement that hydrostatic reduction (HR) is the ideal first-line treatment for childhood intussusception, there is controversy about which technique is best, namely, barium, air, or saline. " 05/01/1994 - "Barium study and computed tomography (CT) helped in the diagnosis of intussusception but the nature of the underlying disease was not determined until histological examination of the gastric specimen was performed." 01/01/2003 - "Barium meal study suggested jejunogastric intussusception. " 02/01/1996 - "Antegrade barium study showed a jejunojejunal intussusception with a soft tissue mass as the lead point. " 06/01/1995 - "In addition, barium studies and computed axial tomography confirmed an intussusception that subsequently developed. "
2.	VaccinesIBA 01/01/2007 - "Both vaccines display 85-98% efficacy against severe rotavirus disease and an excellent tolerability with no difference in side reactions to the placebo controls, particularly with respect to intussusceptions." 01/01/2006 - "Both vaccines display 85-98% efficacy against severe rotavirus disease and an excellent tolerability with no difference in side reactions to the placebo controls, particularly with respect to intussusceptions. " 11/01/2014 - "Following their introduction, post-licensure studies have focused not only on the effectiveness and impact of these vaccines, but also on continued surveillance for intussusception. " 02/01/2014 - "Recently published pharmacoepidemiological studies associate the currently authorized Rotavirus (RV) vaccines with intussusception (IS). " 10/01/2012 - "Before licensure both vaccines were extensively tested for safety (for intussusception) and efficacy in trials comprising in over 60,000 infants each. "
3.	RotaTeqIBA 02/01/2012 - "A significantly greater portion of intussusception AEs in comparison to the portion of total AE reports (removing intussusception AE reports) were reported to VAERS in the onset interval from 3 to 7 days post-RotaTeq vaccination than within the onset interval from 1 to 2 days post-RotaTeq vaccination (78.7% vs. 29.1%, risk ratio=2.7, 95% CI=2.4-3.0, p<0.0001). " 02/01/2012 - "The present study significantly associates RotaTeq vaccination with intussusception AEs." 01/01/2010 - "This study illustrates the feasibility of rapid vaccine safety assessment and provides additional evidence that RotaTeq is not associated with an increased risk of intussusception." 12/30/2009 - "Results of a large-scale Phase III clinical study showed that three doses of RotaTeq were immunogenic, efficacious, and well tolerated with no increased clinical risk of intussusception. " 06/01/2008 - "If, like RotaShield, RotaTeq had a 37-fold increased risk of intussusception within 3 to 7 days after vaccination, then 8 intussusception cases would be expected within 3 to 7 days among the approximately 84000 infants vaccinated with the first dose of RotaTeq in the Vaccine Safety Datalink (N = 49902) and the prelicensure trial (N = 34035) combined, whereas no cases have been observed. "
4.	Butorphanol (BC 2627)FDA LinkGeneric 01/01/1990 - "The results indicate that the use of butorphanol tartrate as part of a preanesthetic protocol is effective in preventing canine intestinal intussusception following renal autotransplantation." 01/01/1990 - "In a prior study, 2 out of 18 dogs undergoing renal autotransplants without the use of butorphanol as part of a 24-h kidney preservation study developed intussusceptions (jejunojejunal). " 01/01/1990 - "Four postoperative intussusceptions were noted (3 jejunojejunal, 1 ileocolic) among the 14 dogs without butorphanol, whereas no intussusceptions developed in the 15 dogs receiving butorphanol as part of the preanesthetic protocol. " 01/01/1990 - "The use of butorphanol tartrate for the prevention of canine intussusception following renal transplantation."
5.	Diatrizoate Meglumine (Gastrograffin)FDA LinkGeneric 01/01/2011 - "In this case, a radiologic examination with gastrografin was useful to detect the typical findings of a small intestinal intussusception, a beak-like filling defect, and identify the location of the lesion. " 01/01/2006 - "While in ileocolic intussusception group, reduction was done by gastrograffin enema (73.8%), spontaneous reduction (0%) and surgical reduction (26.3%), spontaneous reduction was done in 73.3% and surgical reduction in 20% in small bowel intussusception group. " 01/01/2015 - "Diagnostic gastrografin enemas that were performed in four patients excluded intussusception and confirmed stool at the caecum and ascending colon. " 01/01/2012 - "She was clinically diagnosed with ileocolic intussusception on the basis of the findings of computed tomography (CT) and a gastrografin enema. " 08/01/2007 - "Air and Gastrografin(R) enemas were used in an attempt to reduce the intussusception. "
6.	Morphine (MS Contin)FDA LinkGeneric 04/01/1989 - "Postoperative administration of morphine was ineffective in reducing the incidence of intussusception. " 04/01/1989 - "Intraoperative intravenous administration of morphine (0.5 mg/kg) resulted in a reduction in the rate of intussusception to 3.3% (2 of 61 dogs transplanted). " 04/01/1989 - "The results indicate that intraoperative administration of morphine is effective in preventing postoperative intussusception in dogs used for experimental transplantation and may reduce animal losses and research costs in experimental surgical laboratories." 04/01/1989 - "In this report 149 kidney transplants were performed as part of experiments on renal perfusion preservation, and the effect of morphine treatment on the incidence of postoperative intussusception was concurrently evaluated. " 04/01/1989 - "Prevention of postoperative intestinal intussusception by prophylactic morphine administration in dogs used for organ transplantation research."
7.	Kallikreins (Kallikrein)IBA 07/01/2010 - "Treatment with the kallikrein inhibitor, kalbitor, eliminated angioedema and intussusception, though not permanently. "
8.	Inosine Diphosphate (IDP)IBA 03/01/2013 - "The IDP is an effective and safe option for rectal outlet obstruction caused by rectal intussusception with excellent function and patient satisfaction."
9.	Hydrocortisone (Cortisol)FDA LinkGeneric 01/01/2015 - "Case report of severe Cushing's syndrome in medullary thyroid cancer complicated by functional diabetes insipidus, aortic dissection, jejunal intussusception, and paraneoplastic dysautonomia: remission with sorafenib without reduction in cortisol concentration."
10.	medullary Thyroid cancerIBA 01/01/2015 - "This is the first report of paraneoplastic dysautonomia and jejunal intussusception in medullary thyroid cancer, they may be related to medullary thyroid cancer's neuroendocrine origin and metastasis, respectively. " 01/01/2015 - "Diabetes insipidus without intrasellar metastasis, intestinal intussusception, and paraneoplastic dysautonomia have not been reported in medullary thyroid cancer. " 01/01/2015 - "Case report of severe Cushing's syndrome in medullary thyroid cancer complicated by functional diabetes insipidus, aortic dissection, jejunal intussusception, and paraneoplastic dysautonomia: remission with sorafenib without reduction in cortisol concentration."

Therapies and Procedures

1.	Enema (Enemas) 02/01/2008 - "The purpose of the study was to evaluate the efficacy of the technique of hydrostatic reduction of intussusception using saline enema and ultrasound being practiced in our institute; the secondary goal was to identify patient subset in which it is more successful. " 01/01/2008 - "We sought to retrospectively identify computed tomography (CT) criteria that may help to predict bowel viability and successful enema reduction in children with ileocolic intussusception. " 11/01/2006 - "Air enema is a safe and effective approach for uncomplicated intussusception reduction with a high success rate, but the duration of symptoms directly increases the complication rate." 05/01/2004 - "Air enema associated with the use of delayed, repeated reduction attempts is a safe and effective approach for intussusception reduction with a high success rate. " 07/01/2002 - "The aim of this study was to assess the efficacy of sonographically guided hydrostatic enema in therapeutic reduction of intussusception in children and to determine whether certain factors may predict the outcome of this technique. "
2.	Laparotomy 04/28/2015 - "Exploratory laparoscopy or laparotomy is frequently recommended as the best treatment for intussusceptions caused by IFP. " 10/01/2012 - "Exploratory laparotomies later revealed ileo-ileal and jejuno-ileal intussusceptions which were reduced without resection with good outcome. " 01/01/2012 - "In this report, we are presenting a rare case of jejunojejunal intussusception in a 78-year-old female patient with a GIST located in the terminal jejunum being the leading point, demonstrating the importance of imaging studies, especially CT scan, laparoscopy, and exploratory laparotomy as diagnostic and therapeutic interventions." 09/01/2015 - "In the exploratory laparotomy an ileoileal intussusception was confirmed, a mass was found that the histopathology laboratory confirmed as HP. " 05/01/2015 - "On laparotomy Ileo-ileal intussusception (proximal ileum telescoping into distal ileum) was found 2 feet proximal to ileo-caecal junction with surrounding inflammed mesentery and presence of intraluminal tumour as lead point. "
3.	Sutures (Suture) 12/01/2014 - "The study enrolled all patients with OA due to epididymal obstruction who had undergone microsurgical two-suture single-armed longitudinal intussusception vasoepididymostomy in the study hospital from July 2009 to November 2012. " 01/01/2016 - "From July 2012 to July 2013, we reviewed 81 patients with consecutive primary epididymal obstruction who underwent single-armed two-suture longitudinal intussusception microsurgical VEs by a single surgeon, Kai Hong (KH). " 12/01/2014 - "All procedures were performed by Monoski's two single-armed suture longitudinal intussusception techniques. " 09/01/2011 - "At surgery, a 3-cm, ileo-ileal intussusception was noted proximal to the previous Lembert suture site and was manually reduced. " 07/01/2010 - "The procedure was performed bilaterally in six men whereas two patients underwent a two-suture, longitudinal intussusception vasoepididymostomy on the second side. "
4.	General Anesthesia 01/01/2008 - "In dogs with similar findings, the authors recommend ultrasonographic reexamination of the abdomen after general anesthesia (but before surgery) to exclude spontaneous reduction of the intussusception." 05/01/2002 - "The intussusception was diagnosed on ultrasonography and was to be treated laparoscopically, but spontaneous reduction occurred during induction of general anesthesia." 03/01/1999 - "A total of 74 patients with intussusception were divided into two groups: 43 cases in 39 patients between April 1974 and June 1988 were treated under general anesthesia, and 39 cases in 35 patients between July 1988 and January 1994 were treated without it. " 08/01/1989 - "Hydrostatic reduction of ileocolic intussusception: a second attempt in the operating room with general anesthesia." 12/01/2012 - "General anesthesia for intussusception reduction by enema."
5.	Gastrectomy 12/01/2015 - "The aim of the present report was to expand awareness of retrograde jejunojejunal intussusception as an urgent complication following gastrectomy." 12/01/2015 - "Retrograde Jejunojejunal Intussusception After Gastrectomy: Report of Four Cases." 12/01/2013 - "Many retrograde intussusceptions occur during the period following gastrectomy. " 12/01/2013 - "Early Postoperative Retrograde Jejunojejunal Intussusception after Total Gastrectomy with Roux-en-Y Esophagojejunostomy: A Case Report." 07/21/2010 - "Anterograde jejunojejunal intussusception resulted in acute efferent loop syndrome after subtotal gastrectomy."