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Intestinal Pseudo-Obstruction (Intestinal Pseudoobstruction)

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A type of ILEUS, a functional not mechanical obstruction of the INTESTINES. This syndrome is caused by a large number of disorders involving the smooth muscles (MUSCLE, SMOOTH) or the NERVOUS SYSTEM.

Also Known As:

Intestinal Pseudoobstruction; Visceral Myopathy; Idiopathic Intestinal Pseudo-Obstruction; Paralytic Ileus; Intestinal Pseudo-Obstruction, Idiopathic; Idiopathic Intestinal Pseudo-Obstructions; Ileus, Paralytic; Intestinal Pseudo Obstruction; Intestinal Pseudo Obstruction, Idiopathic; Intestinal Pseudo-Obstructions; Intestinal Pseudo-Obstructions, Idiopathic; Intestinal Pseudoobstructions; Myopathies, Visceral; Myopathy, Visceral; Pseudo Obstruction, Intestinal; Pseudo-Obstruction, Idiopathic Intestinal; Pseudo-Obstructions, Idiopathic Intestinal; Pseudo-Obstructions, Intestinal; Pseudoobstruction, Intestinal; Pseudoobstructions, Intestinal; Visceral Myopathies; Pseudo-Obstruction, Intestinal

Networked: 653 relevant articles (29 outcomes, 28 trials/studies)

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Disease Context: Research Results

Digestive System Diseases: 46
- Gastrointestinal Diseases: 1735
  - Intestinal Diseases: 773
    - Intestinal Obstruction: 1669
      - Ileus: 2219
        Intestinal Pseudo-Obstruction: 653
        Colonic Pseudo-Obstruction: 257
        Megacystis microcolon intestinal hypoperistalsis syndrome: 47
        Mitochondrial neurogastrointestinal encephalopathy syndrome: 3
        Congenital idiopathic intestinal pseudoobstruction
        Intestinal Pseudoobstruction with Patent Ductus Arteriosus and Natal Teeth
        Mungan Syndrome
        Visceral myopathy familial external ophthalmoplegia

Related Diseases

1.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
2.	Vomiting
3.	Ileus
4.	Nausea
5.	Constipation

Experts

1.	De Giorgio, Roberto: 7 articles (04/2015 - 05/2004)
2.	Stanghellini, Vincenzo: 5 articles (04/2015 - 05/2004)
3.	Pinna, A D: 5 articles (01/2014 - 05/2002)
4.	Pironi, L: 4 articles (01/2014 - 03/2007)
5.	Zanfi, C: 4 articles (01/2014 - 03/2007)
6.	Lauro, A: 4 articles (01/2014 - 03/2007)
7.	Stanghellini, V: 3 articles (01/2014 - 07/2008)
8.	Ravaioli, M: 3 articles (01/2014 - 03/2007)
9.	Dazzi, A: 3 articles (01/2014 - 03/2007)
10.	Ercolani, G: 3 articles (01/2014 - 03/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intestinal Pseudo-Obstruction:

1.	Cisapride (Propulsid)FDA Link 08/01/1996 - "Therefore, we suggest that a trial of cisapride be considered for patients with acute intestinal pseudo-obstruction when other therapeutic maneuvers have failed." 06/01/1993 - "We assessed upper gastrointestinal anatomy and function with contrast radiology and antroduodenal manometry in 51 children with chronic intestinal pseudo-obstruction (CIP) prior to entering these patients into an open-label outpatient trial of cisapride. " 12/01/1991 - "To assess the effect of cisapride on gastrointestinal motility and gastric emptying in children with chronic intestinal pseudoobstruction, 20 children (mean age, 4.9 years; 14 female and 6 male) who required special means of alimentation or who had severe symptoms confirmed by diary during 2 weeks before the study were studied. " 06/01/1988 - "These studies indicate that antroduodenal manometry is useful for characterizing intestinal pseudo-obstruction, and cisapride stimulates postprandial duodenal contractions in patients with pseudo-obstruction." 06/01/2013 - "Clinical recovery of chronic intestinal pseudo-obstruction with cisapride in a complex pediatric patient."
2.	prucaloprideIBA 01/01/2012 - "Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction--a double-blind, placebo-controlled, cross-over, multiple n = 1 study." 05/27/2014 - "Acute refractory intestinal pseudo-obstruction in MELAS: efficacy of prucalopride." 02/01/2012 - "Prucalopride for chronic intestinal pseudo-obstruction." 01/01/2012 - "Four patients (three visceral myopathy and one visceral neuropathy) completed the study; prucalopride significantly improved pain in three of four patients, nausea in two, vomiting in one, bloating in four and analgesic intake. "
3.	Erythromycin (Erycette)FDA LinkGeneric 03/15/2004 - "All patients with proven chronic intestinal pseudo-obstruction treated with erythromycin were reviewed. " 03/15/2004 - "To determine the value of erythromycin treatment in chronic intestinal pseudo-obstruction. " 03/15/2004 - "Erythromycin for the treatment of chronic intestinal pseudo-obstruction: description of six cases with a positive response." 12/01/1996 - "Our experience suggests that the prokinetic effects of erythromycin may be of therapeutic value in chronic idiopathic intestinal pseudo-obstruction." 12/01/1996 - "Effects of erythromycin in chronic idiopathic intestinal pseudo-obstruction."
4.	Naloxone (Narcan)FDA LinkGeneric 06/01/1985 - "This observation suggests that Naloxone may be helpful in the treatment of some patients with intestinal pseudoobstruction." 10/01/1989 - "Paralytic ileus: response to naloxone." 06/01/1985 - "Beneficial effects of naloxone in a patient with intestinal pseudoobstruction." 07/01/1993 - "Naloxone, an opioid antagonist, appears to hold promise in patients with irritable bowel syndrome, small intestinal pseudo-obstruction, and constipation. " 06/01/1985 - "A 15-day course of Naloxone treatment was given to a patient with intestinal pseudoobstruction who had previously undergone subtotal colectomy with terminal ileostomy for invalidating constipation. "
5.	dai-kenchu-toIBA 01/01/2001 - "Dai-Kenchu-To (DKT) is a herbal medicine and is currently used as the treatment of paralytic ileus in Japan. " 03/01/2015 - "No study has reported whether perioperative administration of Daikenchuto (TJ-100) reduced paralytic ileus after pancreaticoduodenectomy (PD). " 04/01/2013 - "Effect of Daikenchuto (TJ-100) on postoperative bowel motility and on prevention of paralytic ileus after pancreaticoduodenectomy: a multicenter, randomized, placebo-controlled phase II trial (the JAPAN-PD study)." 03/01/2015 - "Perioperative administration of Daikenchuto (TJ-100) reduces the postoperative paralytic ileus in patients with pancreaticoduodenectomy." 04/01/2013 - "We conducted a multicenter, randomized, controlled trial in patients with pancreaticoduodenectomy to investigate the efficacy of Daikenchuto (TJ-100), which is a Kampo medicine (traditional Japanese herbal medicine), for its effect on postoperative bowel motility and for prevention of postoperative paralytic ileus. "
6.	AntibodiesIBA 08/01/2015 - "GAD Antibodies as Key Link Between Chronic Intestinal Pseudoobstruction, Autonomic Neuropathy, and Limb Stiffness in a Nondiabetic Patient: A CARE-Compliant Case Report and Review of the Literature." 03/01/2002 - "A case of SCLC with positive anti-Hu antibodies presenting with intestinal pseudo-obstruction is presented. " 01/01/1996 - "A 60-year-old patient presenting with the typical features of progressive sensory neuronopathy and subsequent intestinal pseudo-obstruction was found to have antineuronal nuclear antibodies (ANNA-I or Anti-Hu). " 03/01/2008 - "High titres of anti-Hu antibodies were detected in patient's serum, supporting the diagnosis of severe paraneoplastic gastroparesis with chronic intestinal pseudo-obstruction. " 11/01/1993 - "Intestinal pseudo-obstruction, type 1 anti-neuronal nuclear antibodies and small-cell carcinoma of the lung."
7.	Octreotide (Sandostatin)FDA LinkGeneric 04/01/2005 - "Octreotide treatment for paraneoplastic intestinal pseudo-obstruction complicating SCLC." 05/01/1992 - "[Octreotide in intestinal pseudo-obstruction?]." 10/01/1997 - "One major complication was observed in the sclerotherapy group (aspiration) and two in the octreotide group (pulmonary oedema, severe paralytic ileus). " 11/01/2006 - "We report a 65-year-old man with carcinoma stomach presenting with intestinal pseudoobstruction, which responded to octreotide." 11/01/2006 - "Gastric adenocarcinoma presenting with intestinal pseudoobstruction, successfully treated with octreotide."
8.	Metronidazole (Metric)FDA LinkGeneric 01/01/2011 - "[Marked efficacy of metronidazole for the intestinal pseudoobstruction associated with systemic sclerosis]." 06/01/1992 - "To the authors' knowledge, this is the first reported case of successful treatment of pneumatosis cystoides intestinalis with metronidazole in primary chronic intestinal pseudoobstruction." 09/01/1983 - "Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin." 06/01/2009 - "A symptomatic therapy with metronidazole and oxygen should be considered, if despite the adequate treatment of the underlying disease, PI continues with abdominal symptoms (such as intestinal pseudo-obstruction or nonspecific abdominal pain)."
9.	Domperidone (Domperidon)IBA 10/01/1990 - "Domperidone in chronic intestinal pseudoobstruction." 12/01/2001 - "Cyclophosphamide is effective in fibrosing alveolitis, prokinetic substances (metoclopramid, domperidone) in gastroesophageal dysmotility or octreotide in intestinal pseudoobstruction. " 04/01/1989 - "anticholinergics (prifinium or actilonium bromide), adrenergic alpha 2-agonists (clonidine, lidamidine) for diarrhoea in diabetic neuropathy, adrenergic beta-blockers for shortening postoperative ileus (propranolol), dopamine receptor antagonists (metoclopramide, domperidone, alizapride) and another prokinetic substance (cisapride) which may be useful for a number of applications as gastro-oesophageal reflux, gastro-paresis, intestinal pseudo-obstruction, cystic fibrosis and constipation, morphine derivatives (e.g. "
10.	Prednisolone (Predate)FDA LinkGeneric 09/25/2012 - "In spite of intensive treatment including oral prednisolone and colchicine, diarrhea and intestinal pseudo-obstruction developed alternately, general status rapidly got worsened and died after two months." 10/01/2010 - "Although intensive care, including treatment with prednisolone and methotrexate, improved the hypovolemic shock, paralytic ileus became dominant instead of the marked diarrhea, suggesting the terminal stage of AA amyloidosis of the GI tract. "

Therapies and Procedures

1.	Home Parenteral Nutrition 03/01/1985 - "Successful management of chronic intestinal pseudo-obstruction with home parenteral nutrition." 12/01/2010 - "Patients suffering from chronic idiopathic intestinal pseudo-obstruction (CIIPO) clearly benefit from home parenteral nutrition (HPN) to maintain adequate nutritional status and general health. " 05/01/2009 - "Long-term outcome of chronic intestinal pseudo-obstruction adult patients requiring home parenteral nutrition." 09/01/1995 - "[Home parenteral nutrition in the management of patients with chronic idiopathic intestinal pseudo-obstruction]." 06/01/1994 - "Chronic intestinal pseudo-obstruction and home parenteral nutrition in children--how do the families cope?"
2.	Hyperbaric Oxygenation 01/01/2000 - "The striking effect of hyperbaric oxygenation therapy in the management of chronic idiopathic intestinal pseudo-obstruction." 01/01/2000 - "These observations strongly suggest that hyperbaric oxygenation can be an effective therapy in the management of chronic idiopathic intestinal pseudo-obstruction." 02/01/2000 - "[A case of chronic idiopathic intestinal pseudo-obstruction and pneumatosis cystoides intestinalis with pneumatoperitoneum, improved by the hyperbaric oxygen therapy]." 10/01/2007 - "Hyperbaric oxygen therapy for the treatment of postoperative paralytic ileus and adhesive intestinal obstruction associated with abdominal surgery: experience with 626 patients." 01/01/2000 - "We report a case of chronic idiopathic intestinal pseudo-obstruction, due to myopathy, in which hyperbaric oxygenation therapy was strikingly effective. "
3.	Pancreaticoduodenectomy 03/01/2015 - "No study has reported whether perioperative administration of Daikenchuto (TJ-100) reduced paralytic ileus after pancreaticoduodenectomy (PD). " 04/01/2013 - "Effect of Daikenchuto (TJ-100) on postoperative bowel motility and on prevention of paralytic ileus after pancreaticoduodenectomy: a multicenter, randomized, placebo-controlled phase II trial (the JAPAN-PD study)." 03/01/2015 - "Perioperative administration of Daikenchuto (TJ-100) reduces the postoperative paralytic ileus in patients with pancreaticoduodenectomy." 04/01/2013 - "We conducted a multicenter, randomized, controlled trial in patients with pancreaticoduodenectomy to investigate the efficacy of Daikenchuto (TJ-100), which is a Kampo medicine (traditional Japanese herbal medicine), for its effect on postoperative bowel motility and for prevention of postoperative paralytic ileus. "
4.	Parenteral Nutrition 07/01/1995 - "This not only relieved the hypersecretory state and improved gastric drainage, but allowed the patient to stop parenteral nutrition and eat regular food for the first time in 10 yr. Select patients with chronic intestinal pseudo-obstruction will respond favorably to palliative surgical intervention." 03/01/2002 - "A 5-year-old male with chronic intestinal pseudo-obstruction required nighttime parenteral nutrition. " 12/01/2000 - "Pregnancy in a patient with chronic intestinal pseudo-obstruction on long-term parenteral nutrition." 11/01/1989 - "In view of the prolonged paralytic ileus complete parenteral feeding must be prescribed in the postoperative period until the function of the gastrointestinal tract becomes normal. " 01/01/1983 - "Chronic idiopathic intestinal pseudo-obstruction in infancy and its successful treatment with parenteral feeding."
5.	Decompression 01/01/1997 - "For determination of the efficacy of intraluminal bowel decompression by an endoscopically placed Dennis tube, 174 patients with paralytic ileus or different kinds of partial small bowel obstruction were reviewed retrospectively. " 09/01/2013 - "Repetitive Colonoscopic Decompression as a Bridge Therapy before Surgery in a Pregnant Patient with Chronic Intestinal Pseudo-Obstruction." 04/01/1984 - "Despite some evidence that gastric decompression may be unnecessary after some abdominal operations and in the treatment of paralytic ileus, the use of nasogastric suction after extensive abdominal operations, particularly intestinal resection, remains a subject of some debate. " 01/01/1984 - "Tube decompression should be used only in patients with paralytic ileus." 11/01/1978 - "[Use of stoma for decompression of the paralytic ileus (author's transl)]."