Intestinal Perforation

01/01/1993 - "Of six patients being followed up for 2-10 yr, one had remission, four needed small maintenance dose of steroid, and one suffered from relapse with intestinal perforation."
04/01/2021 - "Of these, 8 (47%) needed steroids and 1patient required surgery due to intestinal perforation. "
02/16/2017 - "We report a patient with EPGA treated with high-dose steroid who underwent emergency surgery for intestinal perforations. "
01/01/2012 - "Colon perforation after steroid use was first reported by Beck et al in 1950.1 Although the pathophysiological mechanism is not understood clearly, it is claimed that steroids probably by disturbing the intestinal mucosal barrier, facilitate the intestinal perforation. "
09/01/2011 - "Massive use of steroids is common for controlling relapse of this disease, but this increases the risk of intestinal perforation. "

01/01/2015 - "We found no association between administration of rhTM and 28-day mortality in mechanically ventilated patients with septic shock and concurrent DIC after intestinal perforation."
08/31/2015 - "Supplemental dose of antithrombin administration may be associated with reduced 28-day mortality in sepsis-associated DIC patients after emergency laparotomy for intestinal perforation. "
01/01/2015 - "We examined the hypothesis that recombinant human soluble thrombomodulin (rhTM) is effective in the treatment of patients with septic shock with sepsis-induced DIC after laparotomy for intestinal perforation. "
01/01/2015 - "Anticoagulant therapy has been evaluated with respect to its potential usefulness in reducing the high mortality rates associated with severe sepsis, including sepsis-induced disseminated intravascular coagulation (DIC) after intestinal perforation. "
01/01/2023 - "In 14 comparative studies on anti-DIC agents, antithrombin for severe pneumonia, postoperative intestinal perforation, and severe burn, and rTM for acute cholangitis were associated with improved survival rates. "

10/01/2016 - "Prophylactic efficacy of enteral miconazole administration for neonatal intestinal perforation and its potential mechanism."
04/01/2021 - "Prophylactic efficacy of enteral antifungal administration of miconazole for intestinal perforation, especially for necrotizing enterocolitis: a historical cohort study at a single institution."

01/01/2021 - "However, prophylactic indomethacin was associated with increased odds of early mortality or spontaneous intestinal perforation for neonates born at 26-28 weeks of gestational age. "
01/01/2021 - "After we adjusted for confounders, prophylactic indomethacin was associated with reduced odds of early death or severe neurologic injury and early death or spontaneous intestinal perforation in neonates born at 23-24 weeks of gestational age. "
01/01/2021 - "To evaluate the impact of prophylactic indomethacin on early death (<10 days after birth) or severe neurologic injury and on early death or spontaneous intestinal perforation by completed weeks of gestational age in neonates born <29 weeks of gestation. "
01/01/2021 - "To determine if antenatal variables affect the risk of spontaneous intestinal perforation (SIP) among preterm infants when prophylactic indomethacin is used. "
01/01/2021 - "Antenatal Risk Factors Associated with Spontaneous Intestinal Perforation in Preterm Infants Receiving Postnatal Indomethacin."

05/01/2000 - "The patients who achieved a complete remission with medical treatment, who had no history of intestinal perforation, and who received azathioprine after operation showed better clinical courses. "
01/01/2014 - "We present the case of perinatal focal intestinal perforation with a meconium pseudocyst in a preterm infant of a mother with autoimmune hepatitis on azathioprine and methylprednisone."
12/10/1974 - "[Effective use of azathioprine in a case of polyarteritis nodosa with recurrent intestinal perforation: a distinction between polyarteritis nodosa and allergic granulomatous angiitis]."

12/01/1989 - "This technique is difficult to perform and has the added risk of intestinal perforation but does obviate anesthetic and surgical risks. "
05/01/2005 - "Percutaneous endoscopic gastrostomy (PEG) insertion, considered by many to be the "gold standard," is unavoidably associated with a risk of intestinal perforation and frequently requires a second anesthetic for its replacement with a low-profile "button." We hypothesized that a laparoscopic technique with low-pressure insufflation would yield comparable outcomes, a lower procedural complication rate, and require fewer anesthetics per patient. "
03/01/1989 - "Twenty days after initiation of antifungal treatment, a clinical suspicion of intestinal perforation arose and an exploratory laparotomy was scheduled, but the patient died during the anesthetic induction. "

01/01/2021 - "Recombinant Human Thrombomodulin Has Additive Effects in Septic Patients Undergoing Continuous Hemodiafiltration Due to Intestinal Perforation."
01/01/2015 - "Use of recombinant human soluble thrombomodulin in patients with sepsis-induced disseminated intravascular coagulation after intestinal perforation."
01/01/2015 - "We examined the hypothesis that recombinant human soluble thrombomodulin (rhTM) is effective in the treatment of patients with septic shock with sepsis-induced DIC after laparotomy for intestinal perforation. "

11/01/2007 - "Concomitant use of hydrocortisone and the nonspecific cyclo-oxygenase (COX)-inhibitor indomethacin increases the risk for intestinal perforations in preterm infants. "
05/01/2009 - "We then evaluated the following properties of these parenterally administered test drugs: (i) GI toxicity (luminal and faecal haemoglobin; intestinal perforations and adhesions; and haematocrit); (ii) bioavailability (plasma indomethacin); and (iii) therapeutic efficacy (analgesia from sensitivity to pressure; anti-inflammatory from ankle thickness; cyclo-oxygenase (COX) inhibition from synovial fluid prostaglandin E(2) concentration) in rats with adjuvant-induced joint inflammation. "

01/01/2017 - "According to the Louw and Barnard classification, type 1 atresia has been defined as an intra-luminal web which results in either complete (web with no perforation) or incomplete (web with central perforation) intestinal obstruction. "
05/01/2009 - "We then evaluated the following properties of these parenterally administered test drugs: (i) GI toxicity (luminal and faecal haemoglobin; intestinal perforations and adhesions; and haematocrit); (ii) bioavailability (plasma indomethacin); and (iii) therapeutic efficacy (analgesia from sensitivity to pressure; anti-inflammatory from ankle thickness; cyclo-oxygenase (COX) inhibition from synovial fluid prostaglandin E(2) concentration) in rats with adjuvant-induced joint inflammation. "

05/01/2004 - "She experienced 2 more episodes of intestinal perforations during the second and fifth weeks despite intense immunosuppressive treatment with methylprednisolone and cyclophosphamide. "
05/27/2023 - "Pulse steroid therapy combined with cyclophosphamide improved the patient's condition without any serious complications, such as intestinal perforation."

09/01/2006 - "Our data suggest that laparotomy, either alone or after PD, provides an improved outcome in VLBW infants with intestinal perforation. "
07/01/2020 - "The purpose of our study was to compare outcomes of infants with spontaneous intestinal perforation (SIP) treated with primary peritoneal drain versus primary laparotomy. "
07/06/2023 - "to systematically review and meta-analyze the impact on morbidity and mortality of peritoneal drainage (PD) compared to laparotomy (LAP) in preterm neonates with surgical NEC (sNEC) or spontaneous intestinal perforation (SIP). "
10/01/2022 - "Five patients required surgical (laparotomy or laparoscopy) removal of multiple magnets with intestinal perforations. "
07/01/2022 - "Small sample size, high heterogeneity, NEC, and spontaneous intestinal perforation (SIP) had to be analyzed together, lack of selection criteria for the future selection of an intervention, and no clear, standardized procedures.   Conclusion: There was no significant difference in mortality between peritoneal drainage and laparotomy as initial surgical intervention. "

02/01/2023 - "Intestinal perforation can occur before or at the beginning of anti-tubercular therapy. "
11/12/2021 - "Endoscopic vacuum therapy (EVT) has become a widely used method for the treatment of intestinal perforations and leakages. "
07/01/2021 - "Intestinal perforation in gastrointestinal TB can occur as a paradoxical reaction to antitubercular therapy. "
07/01/2021 - "Intestinal Perforation as a Paradoxical Reaction to Antitubercular Therapy: A Case Report."
03/01/2019 - "Lower intestinal perforation is an uncommon but serious AE in TCZ therapy. "

12/01/2020 - "PDA and delay in first enteral nutrition were predisposing factors for acquiring NEC and low 5-minutes Apgar scores for intestinal perforation. "
12/01/2020 - "Timing of first enteral feeding and hemodynamically significant PDA were predisposing factors for NEC and low 5-minutes Apgar score for intestinal perforation. "
12/01/2020 - "Timing of first enteral feeding was associated to developing NEC, but not to intestinal perforation (p < 0.001, p = 0.604). "
03/01/2012 - "Its presence may at best delay establishment of enteral feeding and compromise nutrition and at worst lead to mechanical obstruction requiring surgery or to intestinal perforation. "
12/01/2007 - "Finally, infants with spontaneous intestinal perforation had delayed enteral feeding (64 +/- 30 vs 31 +/- 10 days) and prolonged hospitalization (155 +/- 48 vs 108 +/- 36 days). "

07/01/2007 - "T-tube ileostomy is an effective and safe technique for treatment of selected cases of intestinal perforation in ELBW neonates. "
09/15/2023 - "Two years ago, He suffered intestinal perforation and received enterectomy and ileostomy. "
01/01/2018 - "He received an ileostomy because of an intestinal perforation. "
08/01/2016 - "Long term outcome of preterm infants with isolated intestinal perforation: A comparison between primary anastomosis and ileostomy."
01/01/2016 - "Partial resection of the intestine and ileostomy might be useful for removing the intestinal perforations caused by a CCE. "

11/01/2017 - "In recent years, improved survival rates of extremely low birth weight infants (ELBWIs) have led to an increasing number of enterostomy performed for those with meconium obstruction of prematurity (MOP)1,2, spontaneous intestinal perforation (SIP)3,4. "
05/01/2021 - "What is Known: • Enterostomy (ES) and primary anastomosis (PA) are feasible treatment options in preterm infants with spontaneous intestinal perforation (SIP). "
05/01/2021 - "The aim was to assess the results of primary anastomosis (PA) compared to enterostomy (ES) in infants with spontaneous intestinal perforation (SIP) and a weight below 1000 g. "
08/01/2020 - "No consensus guidelines exist for timing of enterostomy closure in neonatal isolated intestinal perforation (IIP). "
08/01/2020 - "Timing of enterostomy closure for neonatal isolated intestinal perforation."