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Intestinal Atresia

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Congenital obliteration of the lumen of the intestine, with the ILEUM involved in 50% of the cases and the JEJUNUM and DUODENUM following in frequency. It is the most frequent cause of INTESTINAL OBSTRUCTION in NEWBORNS. (From Stedman, 25th ed)

Also Known As:

Apple Peel Syndrome; Apple-Peel Intestinal Atresia; Congenital Intestinal Atresia; Familial Apple Peel Jejunal Atresia; Jejunal Atresia; Apple Peel Intestinal Atresia; Apple Peel Syndromes; Apple-Peel Intestinal Atresias; Atresia, Apple-Peel Intestinal; Atresia, Congenital Intestinal; Atresia, Jejunal; Atresias, Apple-Peel Intestinal; Atresias, Congenital Intestinal; Congenital Intestinal Atresias; Intestinal Atresia, Apple-Peel; Intestinal Atresia, Congenital; Intestinal Atresias, Apple-Peel; Intestinal Atresias, Congenital; Atresia, Intestinal

Networked: 168 relevant articles (4 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Necrotizing Enterocolitis
2.	Pathologic Constriction (Stenosis)
3.	Umbilical Hernia (Omphalocele)
4.	Diaphragmatic Hernia
5.	Esophageal Atresia

Experts

1.	Li, Long: 2 articles (08/2014 - 01/2013)
2.	Li, Bing: 2 articles (08/2014 - 01/2013)
3.	National Birth Defects Prevention Study: 2 articles (12/2012 - 02/2012)
4.	Shaw, Gary M: 2 articles (12/2012 - 10/2004)
5.	Druschel, Charlotte M: 2 articles (02/2012 - 02/2011)
6.	Romitti, Paul A: 2 articles (02/2012 - 02/2011)
7.	Browne, Marilyn L: 2 articles (02/2012 - 02/2011)
8.	Sudan, Debra L: 2 articles (07/2008 - 02/2004)
9.	Warburton, David: 2 articles (01/2006 - 02/2005)
10.	Bellusci, Saverio: 2 articles (01/2006 - 02/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intestinal Atresia:

1.	teduglutideIBA 12/01/2009 - "On the basis of promising results from teduglutide studies in adults with SBS and from studies in neonatal and juvenile animal models, a pediatric multiple-dose phase I clinical study was designed to determine the safety, efficacy, and pharmacokinetics of teduglutide in pediatric patients with SBS who have undergone resection for necrotizing enterocolitis, malrotation, or intestinal atresia. "
2.	Anorectal atresiaIBA 08/01/2015 - "A higher percentage of unmet basic needs was associated with a higher lethality for diaphragmatic hernia -OR: 1.59 (95% CI: 1.30-1.95)- and for intestinal atresia or anorectal malformation -OR: 16.00 (95% CI: 1.63-157.24)-. " 05/01/2011 - "Those with intestinal atresia, anorectal malformation, malrotation, cystic fibrosis and prematurity were excluded. " 12/01/2004 - "Intestinal atresia ranks as the second most common cause of neonatal intestinal obstruction (after anorectal malformation) in our hospital. " 12/01/2002 - "During the period 1994-2001 at the authors' departments a 73% survival of neonates with an isolated diaphragmatic hernia was recorded, 87% with omphalocele, 93% with gastroschisis, 90% with oesophageal atresia, 97% with anorectal atresia and 100% with intestinal atresia. " 07/01/2012 - "This study is based on 11 cases (2 esophageal atresia, 2 diaphragmatic hernias, 1 necrotizing enterocolitis, 3 intestinal atresia, 2 anorectal malformation and 1 bladder exstrophy) and 22 controls. "
3.	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 01/01/2006 - "This study evaluates the role of Fgfr2b signaling in regulating proliferation and apoptosis in the pathogenesis of intestinal atresia. " 01/01/2006 - "Inhibited proliferation and increased apoptosis are specific to those tissues of normal Fgfr2b expression, corresponding to the site of intestinal atresia. " 01/01/2006 - "Fgfr2b invalidation results in an autosomal recessive intestinal atresia phenotype. " 02/01/2005 - "The patent colonic mesentery of the Fgf10(-/-) and Fgfr2b(-/-) mutants challenges an accepted pathogenesis of intestinal atresia. " 08/01/2004 - "The Fgf10(-/-) and Fgfr2b(-/-) mutants represent a genetically reproducible animal model of autosomal recessive intestinal atresia."
4.	AnotiaIBA 10/01/2004 - "Malformation phenotypes studied were spina bifida, anencephaly, cleft lip, cleft palate, tetralogy of Fallot, d-transposition of great arteries, hypospadias, small intestinal atresia, preaxial polydactyly, microtia, and hypertrophic pyloric stenosis. " 02/01/2011 - "We observed small, statistically significant elevations in adjusted odds ratios ranging from 1.3 to 1.8 for total maternal dietary caffeine intake or specific types of caffeinated beverages and anotia/microtia, esophageal atresia, small intestinal atresia, and craniosynostosis; however, dose-response patterns were absent. " 02/01/2011 - "Using data from the National Birth Defects Prevention Study (NBDPS), we examined the association between maternal caffeine consumption and anotia/microtia, esophageal atresia, small intestinal atresia, craniosynostosis, diaphragmatic hernia, omphalocele, and gastroschisis. "
5.	Bone Morphogenetic Protein 2IBA 10/01/2013 - "The purpose of this study was to explore the mechanisms of postoperative intestinal motility disorders in intestinal atresia patients by investigating the expression profiles of proteins, including calretinin (CR), glial-derived neurotrophic factor (GDNF), bone morphogenetic protein 2 (BMP-2), c-kit, α-smooth muscle actin (α-SMA), and S-100 protein; to decipher the correlation between the area of the pathological segment and the alteration of the above 6 proteins; and thereby to provide a clinical specific reference values to determine the removal length for intestinal tract resection. "
6.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 10/01/2013 - "Immunohistochemistry technique was applied to detect the CR, c-kit, GDNF, BMP-2, α-SMA, and S-100 protein in specimens of atretic, proximal, and distal intestine from 25 cases of intestinal atresia and samples of intestinal walls from 10 non-atresia control specimens. " 10/01/2013 - "The purpose of this study was to explore the mechanisms of postoperative intestinal motility disorders in intestinal atresia patients by investigating the expression profiles of proteins, including calretinin (CR), glial-derived neurotrophic factor (GDNF), bone morphogenetic protein 2 (BMP-2), c-kit, α-smooth muscle actin (α-SMA), and S-100 protein; to decipher the correlation between the area of the pathological segment and the alteration of the above 6 proteins; and thereby to provide a clinical specific reference values to determine the removal length for intestinal tract resection. "
7.	Proteins (Proteins, Gene)IBA 10/01/2013 - "The purpose of this study was to explore the mechanisms of postoperative intestinal motility disorders in intestinal atresia patients by investigating the expression profiles of proteins, including calretinin (CR), glial-derived neurotrophic factor (GDNF), bone morphogenetic protein 2 (BMP-2), c-kit, α-smooth muscle actin (α-SMA), and S-100 protein; to decipher the correlation between the area of the pathological segment and the alteration of the above 6 proteins; and thereby to provide a clinical specific reference values to determine the removal length for intestinal tract resection. "
8.	S100 Proteins (S 100 Protein)IBA 10/01/2013 - "Immunohistochemistry technique was applied to detect the CR, c-kit, GDNF, BMP-2, α-SMA, and S-100 protein in specimens of atretic, proximal, and distal intestine from 25 cases of intestinal atresia and samples of intestinal walls from 10 non-atresia control specimens. " 10/01/2013 - "The purpose of this study was to explore the mechanisms of postoperative intestinal motility disorders in intestinal atresia patients by investigating the expression profiles of proteins, including calretinin (CR), glial-derived neurotrophic factor (GDNF), bone morphogenetic protein 2 (BMP-2), c-kit, α-smooth muscle actin (α-SMA), and S-100 protein; to decipher the correlation between the area of the pathological segment and the alteration of the above 6 proteins; and thereby to provide a clinical specific reference values to determine the removal length for intestinal tract resection. "
9.	Caffeine (No Doz)FDA LinkGeneric 02/01/2011 - "We observed small, statistically significant elevations in adjusted odds ratios ranging from 1.3 to 1.8 for total maternal dietary caffeine intake or specific types of caffeinated beverages and anotia/microtia, esophageal atresia, small intestinal atresia, and craniosynostosis; however, dose-response patterns were absent. " 02/01/2011 - "Using data from the National Birth Defects Prevention Study (NBDPS), we examined the association between maternal caffeine consumption and anotia/microtia, esophageal atresia, small intestinal atresia, craniosynostosis, diaphragmatic hernia, omphalocele, and gastroschisis. "
10.	calretininIBA 10/01/2013 - "The purpose of this study was to explore the mechanisms of postoperative intestinal motility disorders in intestinal atresia patients by investigating the expression profiles of proteins, including calretinin (CR), glial-derived neurotrophic factor (GDNF), bone morphogenetic protein 2 (BMP-2), c-kit, α-smooth muscle actin (α-SMA), and S-100 protein; to decipher the correlation between the area of the pathological segment and the alteration of the above 6 proteins; and thereby to provide a clinical specific reference values to determine the removal length for intestinal tract resection. "

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 09/01/2013 - "With programs such as the IRP, patients with short bowel secondary to intestinal atresia can show improvement in liver function and nutritional parameters, and discontinue PN, avoiding the need for transplantation." 02/01/2004 - "Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency." 12/01/2015 - "We report the occurrence of TS in a 20-month-old girl with multivisceral transplantation due to short-bowel syndrome secondary to intestinal atresia and gastroschisis. "
2.	Total Parenteral Nutrition 05/01/1993 - "Major assets in the improved outlook for intestinal atresia are prenatal diagnosis, regionalization of neonatal care, improved recognition of associated conditions, innovative surgical methods, and uncomplicated long-term total parenteral nutrition." 01/01/2001 - "Eight (3.46+/-1.0 kg), hemodynamically stable, total parenteral nutrition (TPN)-fed, nonventilated, surgical neonates (5 with gastroschisis, 2 with intestinal atresia, and 1 with intestinal volvulus) were studied on postoperative day 15.5+/-11.9. " 09/01/2007 - "Demographic data and outcome measures including discharge or death, simple versus complex (intestinal atresia, perforation, bowel necrosis, or volvulus), length of stay, mechanical ventilation and total parenteral nutrition, commencement of enteral feeds and age at reaching full feeds, and number of episodes of bacteremia were evaluated. "
3.	Neonatal Intensive Care 12/01/2004 - "Mortality from intestinal atresia is still high in our environment, due mainly to lack of neonatal intensive care facilities." 01/01/2000 - "While the survival of children with intestinal atresia and stenosis has improved over the years in developed countries, ours is still low (59%) due to late presentation and lack of neonatal intensive care facilities."
4.	Parenteral Nutrition 11/15/2015 - "The presence of intestinal atresia was the only factor correlated with prolonged parenteral nutrition, delayed total oral milk feeding and longer hospitalization. " 02/01/2013 - "Aspects of care such as strategy for intestinal atresia and delivery of parenteral nutrition differ significantly between WE and EE. " 07/01/2008 - "For four infants with intestinal atresia a significant difference was demonstrated for induction of preterm labour (P<0.05), duration of parenteral nutrition (P<0.01), number of additional surgical procedures (P<0.001) and length of hospital stay (P<0.01). " 11/01/2007 - "After exclusion of infants with short bowel syndrome and/or intestinal atresia (n = 9), there was a shorter time to full enteral feeds in the TC group (22 (12-36) versus 27 (17-45); P = 0.07), although there was no difference in the period of parenteral nutrition (PN) (P = 0.1) or overall hospital stay (P = 0.34). " 09/01/1984 - "One of the infants received parenteral nutrition for 5 months because of intestinal dysfunction and enterocolitis secondary to extensive aganglionosis, while the second child was premature and placed on parenteral nutrition because of bowel dysfunction after surgery to repair high jejunal atresia and a right diaphragmatic hernia. "
5.	Nursing Care 08/23/1979 - "Nursing care study: apple peel syndrome. "