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Intervertebral Disk Displacement (Herniated Disc)

Subscribe to New Research on Intervertebral Disk Displacement

An intervertebral disk in which the nucleus pulposus has protruded through surrounding fibrocartilage. This occurs most frequently in the lower lumbar region.

Also Known As:

Herniated Disc; Intervertebral Disc Displacement; Herniated Disk; Slipped Disk; Disk Prolapse; Disc Displacement, Intervertebral; Disc Displacements, Intervertebral; Disc, Herniated; Discs, Herniated; Disk Displacement, Intervertebral; Disk Displacements, Intervertebral; Disk Prolapses; Disk, Prolapsed; Disk, Slipped; Disks, Herniated; Disks, Prolapsed; Disks, Slipped; Displacement, Intervertebral Disc; Displacement, Intervertebral Disk; Displacements, Intervertebral Disc; Displacements, Intervertebral Disk; Herniated Discs; Herniated Disks; Intervertebral Disc Displacements; Intervertebral Disk Displacements; Prolapse, Disk; Prolapsed Disks; Prolapses, Disk; Slipped Disks; Disk, Herniated; Prolapsed Disk

Networked: 465 relevant articles (26 outcomes, 44 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Radiculopathy (Radiculopathy, Cervical)
3.	Intervertebral Disk Displacement (Herniated Disc)
4.	Sciatica (Sciatic Neuralgia)
5.	Low Back Pain (Lumbago)

Experts

1.	Haro, Hirotaka: 10 articles (07/2014 - 05/2002)
2.	Komori, Hiromichi: 5 articles (07/2014 - 05/2002)
3.	Lee, Sang-Ho: 4 articles (01/2015 - 08/2005)
4.	Bartels, Ronald H M A: 4 articles (08/2014 - 07/2005)
5.	Ohba, Tetsuro: 4 articles (07/2014 - 11/2008)
6.	Kato, Tsuyoshi: 4 articles (07/2014 - 05/2002)
7.	Parker, Scott L: 3 articles (06/2015 - 12/2011)
8.	McGirt, Matthew J: 3 articles (06/2015 - 12/2011)
9.	Ando, Takashi: 3 articles (07/2013 - 11/2008)
10.	Koyama, Kensuke: 3 articles (07/2013 - 11/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intervertebral Disk Displacement:

1.	OzoneIBA 11/01/2015 - "Because of the lack of a control group and short follow-up times, conclusions about the safety and efficacy of ozone injections for the treatment of herniated discs are not warranted. " 03/01/2012 - "Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials." 12/01/2014 - "To determine the effect of intradiscal ozone injection on pain score and disability in patients with LBP from disk prolapsed. " 04/01/2012 - "The treatment of a herniated disk by injecting a gaseous oxygen-ozone mixture inside the nucleus pulposus is a great clinical success. " 04/01/2010 - "Oxygen/ozone treatment of herniated discs is an effective and extremely safe procedure. "
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/01/2000 - "The authors determined the molecular weight and concentration of active tumor necrosis factor-alpha in rat herniated disc and used exogenous tumor necrosis factor-alpha at the same molecular weight to study its neuropathologic effect on rat nerve root and dorsal root ganglion preparations in vivo. " 09/01/2008 - "Spondylotic discs also had thicker bony endplates and expressed TNFalpha and MMP-3 more diffusely than herniated discs, especially in the inner layer of the anulus fibrosus. " 09/01/2008 - "Our results suggest that the effects of LIPUS in enhancing the process of herniated disc resorption are caused mainly by TNF-alpha." 01/01/2000 - "Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption." 11/01/2014 - "We recently demonstrated that tumor necrosis factor-α receptor (TNFR) levels in the spinal cord correlate with pain sensation in herniated disc patients in a rat chronic constriction injury (CCI) model. "
3.	Pregnenolone Carbonitrile (PCN)IBA 07/01/2014 - "All included studies showed PCN to be an effective and safe procedure in the treatment of (contained) herniated disks at short-, mid-, and long-term follow-up. " 06/01/2013 - "Percutaneous cervical nucleoplasty (PCN) is a safe and effective treatment in symptomatic patients with contained cervical herniated disks. " 07/01/2014 - "Therefore, we systematically reviewed the evidence on the efficacy and safety of PCN in patients with a (contained) herniated disk. " 06/01/2013 - "These results show long-term effectiveness and safety of PCN in patients with a one-level contained cervical herniated disk, and the reliance of selecting patients meeting ideal criteria for successful PCN." 11/01/2010 - "A retrospective of patients with symptomatic contained cervical disc herniated were operated on with PCN and PCD from June 2003 to July 2005. "
4.	Chymopapain (Chymodiactin)FDA Link 04/01/1993 - "The present study describes the radiological and histological changes in the canine intervertebral disk after the experimental injection of chymopapain as the chemical reagent, and determines the appropriate dose of the enzyme for treatment of herniated disks. " 11/01/1986 - "Even though these findings could not be correlated with clinical success or failure using the criteria in this study, six of the original 39 patients were diagnosed as having free disk fragments on the basis of their initial MR scans, a fact that does have management implications for the use of chymopapain in treatment of herniated disk disease." 03/01/2005 - "Herniated discs after administration of MMP-7 and chymopapain showed a significant decrease in protruded mass 7 days after administration compared with saline-treated discs when evaluated by myelography (p<0.01). " 08/10/1992 - "[Lumbar disk prolapse treated with chymopapain]." 10/01/1988 - "16 patients suffering from a herniated disc with purely lumbalgic manifestations were treated with chymopapain nucleolysis. "
5.	OxygenIBA 04/01/2012 - "The treatment of a herniated disk by injecting a gaseous oxygen-ozone mixture inside the nucleus pulposus is a great clinical success. " 04/01/2010 - "Oxygen/ozone treatment of herniated discs is an effective and extremely safe procedure. " 04/01/2010 - "Random-effects metaanalyses were used to estimate outcomes for oxygen/ozone treatment of herniated discs. " 10/10/2003 - "Mini-invasive treatment of herniated disc by oxygen-ozone injection." 01/01/2001 - "The significant increase in lipid peroxidation levels and collagenase activity, and the low metal levels suggest the enhancement of cell death signals in herniated discs, caused by oxygen stress. "
6.	Chondroitin ABC LyaseIBA 07/01/1997 - "Chemonucleolytic treatment with chondroitinase ABC is an effective and safe method for the management of canine intervertebral disc displacement." 07/01/1997 - "To determine the efficacy of Chondroitinase ABC in the management of canine intervertebral disc displacement. " 07/01/2004 - "[Treatment of lumbar intervertebral disc displacement with chondroitinase ABC--experimental basis for clinical application]." 07/01/1997 - "Fifty-nine dogs with symptoms and signs of intervertebral disc displacement were treated with Chondroitinase ABC by a single intradisc injection. " 07/01/1997 - "Treatment of canine intervertebral disc displacement with chondroitinase ABC."
7.	Methylprednisolone FDA LinkGeneric 09/01/2008 - "Epidural methylprednisolone enhances recovery after discectomy for herniated disc disease without apparent side effects." 09/01/2008 - "Through 2001 and 2003 200 patients undergoing discectomy for herniated disc disease were randomly allocated to receive epidural methylprednisolone 40 mg or none. " 09/01/2011 - "The objective of this study was to compare the efficacy of two different solutions--methylprednisolone with saline and methylprednisolone with levobupivacaine injected in the epidural space to heal lombosciatalgia secondary to lumbar herniated disk. "
8.	Clonidine (ST 155)FDA LinkGeneric 01/01/2002 - "The aim of this double-blind randomized study was to evaluate the optimal intravenous dose of clonidine administrated during the peri-operative period, after lumbar hemilaminectomy for herniated disk repair. " 01/01/2014 - "Although transforaminal epidural steroid injections under fluoroscopic guidance have become a common mode of treatment of lumbosacral radiculopathy due to herniated disc, the efficacy of steroid with low doses of clonidine has not been compared yet. "
9.	Thioctic Acid (Lipoic Acid)IBA 01/01/2008 - "This study aimed to compare, for the first time, the efficacy of oral treatment with ALC or thioctic acid in patients with peripheral neuropathic (sciatic) pain associated with a herniated disc. " 01/01/2008 - "Thioctic acid 600 mg/day appears to be at least as effective as ALC in the treatment of sciatic pain caused by a herniated disc and may be associated with an improvement in symptom scores and reduced need for analgesia. " 01/01/2008 - "Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study."
10.	levobupivacaine (Chirocaine)FDA Link 09/01/2011 - "The objective of this study was to compare the efficacy of two different solutions--methylprednisolone with saline and methylprednisolone with levobupivacaine injected in the epidural space to heal lombosciatalgia secondary to lumbar herniated disk. "

Therapies and Procedures

1.	Diskectomy (Discectomy) 06/20/1998 - "We conclude that surgical discectomy is the best treatment option for a herniated disc when conservative efforts have failed." 07/01/2011 - "Our results indicate that lumbar discectomy surgery significantly improved depression and disability in patients with chronic herniated discs." 05/01/1996 - "For carefully selected patients with herniated discs, surgical discectomy is a cost-effective treatment. " 03/30/1999 - "This study was conducted in order to evaluate the cost-effectiveness of percutaneous automated lumbar nucleotomy in comparison with traditional macro-procedure discectomy in the treatment of herniated discs. " 01/01/2015 - "Anterior cervical discectomy and fusion is a common surgical procedure performed to remove a degenerative or herniated disc in cervical spine. "
2.	Injections 07/01/2008 - "In patients with symptoms caused by intervertebral disk displacement, studies of epidural corticosteroid injections have produced compelling evidence of a short-term analgesic effect (lasting about 3 weeks), despite a number of discrepancies. " 08/01/2002 - "Epidural steroid injections have a reasonable success rate for the alleviation of radicular symptoms from lumbar herniated discs for up to twelve to twenty-seven months. " 12/01/2014 - "Use of magnetic resonance imaging to identify outcome predictors of caudal epidural steroid injections for lower lumbar radicular pain caused by a herniated disc." 07/01/2011 - "The dosages of corticosteroid in transforaminal epidural steroid injections for lumbar radicular pain due to a herniated disc." 01/01/2011 - "Satisfactory results have been seen with epidural steroid injections (ESI) in patients with herniated disks (HD), but the role in lumbar spinal stenosis (LSS) has been less investigated. "
3.	Percutaneous Diskectomy 07/01/2006 - "The location of the herniated disc is a parameter which appears to be very important in the efficacy of percutaneous discectomy. " 04/01/1995 - "The imaging studies were evaluated to determine whether the preoperative appearance of the herniated disc was predictive of the outcome of percutaneous discectomy and also to determine a possible mechanism of action of the procedure in the relief of symptoms. " 01/01/2011 - "Short-term follow-up: micro-invasive therapy of the cervical herniated disk by percutaneous nucleotomy." 10/01/2007 - "Percutaneous discectomy is a minimally invasive surgical procedure that treats contained, herniated discs. " 07/01/1999 - "[Percutaneous nucleotomy procedures in lumbar intervertebral disk displacement. "
4.	Decompression 12/01/2014 - "Magnetic resonance images demonstrated a sufficient decompression of the spinal cord with a spontaneous regression of the herniated disc at one year after surgery. " 10/01/2014 - "Targeted PLDD is an alternative technique that involves elimination and decompression of the target area located 5-8 mm in the front of the herniated disc. " 01/01/2013 - "The acute decompression of the herniated disc resulted in cord expansion and rush-in reperfusion. " 02/01/2012 - "We identified adults who underwent an initial inpatient lumbar decompression for herniated disc from 1997 to 2007. " 02/01/2012 - "Repeat surgery after lumbar decompression for herniated disc: the quality implications of hospital and surgeon variation."
5.	Traction 05/01/2006 - "In conclusion, lumbar traction is both effective in improving symptoms and clinical findings in patients with lumbar disc herniation and also in decreasing the size of the herniated disc material as measured by CT." 01/01/1985 - "In this way it was possible to study the configuration of the herniated disc during the time the traction force was applied. " 06/01/2015 - "Continuous traction on herniated lumbar disks and surrounding structures resulted in change in disk shape, disk reduction with opening in the intervertebral disk, reduction of herniated disk volume, separation of the disk and adjoining nerve root, and widening of the facet joint. " 05/01/2010 - "Therefore, the purpose of this case report was to describe and discuss the use of mechanical traction in conjunction with lumbar extension exercises for a patient with a lumbar herniated disc. " 05/01/2010 - "Lumbar extension exercises in conjunction with mechanical traction for the management of a patient with a lumbar herniated disc."