Intertrigo

A superficial dermatitis occurring on skin surfaces in contact with each other, such as the axillae, neck creases, intergluteal fold, between the toes, etc. Obesity is a predisposing factor. The condition is caused by moisture and friction and is characterized by erythema, maceration, burning, and exudation.

Networked: 87 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neck Pain (Cervicalgia)
2.	Hypesthesia (Numbness)
3.	Mastodynia
4.	Shoulder Pain
5.	Ulnar Nerve Compression Syndromes (Ulnar Nerve Entrapment)

Experts

1.	Choate, Evan A: 2 articles (03/2020 - 02/2020)
2.	Sarantopoulos, George P: 2 articles (03/2020 - 02/2020)
3.	Truong, Allison K: 2 articles (03/2020 - 02/2020)
4.	Worswick, Scott D: 2 articles (03/2020 - 02/2020)
5.	Hahnel, Elisabeth: 2 articles (05/2019 - 01/2019)
6.	Kottner, Jan: 2 articles (05/2019 - 01/2019)
7.	Mistiaen, Patriek: 2 articles (07/2010 - 02/2004)
8.	Kulthanan, Kanokvalai: 1 article (02/2022)
9.	Leeyaphan, Charussri: 1 article (02/2022)
10.	Lertrujiwanit, Kamonpan: 1 article (02/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intertrigo:

1.	Zinc OxideFDA Link 07/01/2013 - "In this phase III open labeled, multicenter, non-controlled, non-randomized trial, irritant dermatitis in children and adults either due to diaper rash, pityriasis alba and irritant dermatitis (eczema), perioral dermatitis, perleche or intertrigo were administered; repairing cream RV 2427 B containing a) 4 % zinc oxide, b) 2.5 % dry colloidal oat extract, (c) 0.5 % oat oil, (d) 0.2% copper sulfate, and (e) 0.1 % zinc sulfate to be applied twice-daily in the affected area. " 04/01/2021 - "To assess by clinical and instrumental evaluation the efficacy and tolerability of a new barrier spray containing zinc gluconate-taurine complex and zinc oxide combined with panthenol, glycerin, and Shea (Butyrospermum parkii) butter in mild-to-moderate intertrigo in athletes and overweight subjects. "
2.	Miconazole (Monistat)FDA LinkGeneric 04/01/1990 - "Problems with clinical trials in general practice--a double-blind comparison of cream containing miconazole and hydrocortisone with hydrocortisone alone in the treatment of intertrigo." 02/01/2007 - "A paste enriched or not with miconazole nitrate is indicated to prevent or treat most presentations of intertrigo."
3.	Hydrocortisone (Cortisol)FDA LinkGeneric 04/01/1990 - "Problems with clinical trials in general practice--a double-blind comparison of cream containing miconazole and hydrocortisone with hydrocortisone alone in the treatment of intertrigo." 02/01/2022 - "To evaluate the efficacies and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin for the treatment of mild-to-moderate intertrigo, relative to 1% hydrocortisone cream. "
4.	Copper Sulfate (Sulfate, Copper)FDA Link 07/01/2013 - "In this phase III open labeled, multicenter, non-controlled, non-randomized trial, irritant dermatitis in children and adults either due to diaper rash, pityriasis alba and irritant dermatitis (eczema), perioral dermatitis, perleche or intertrigo were administered; repairing cream RV 2427 B containing a) 4 % zinc oxide, b) 2.5 % dry colloidal oat extract, (c) 0.5 % oat oil, (d) 0.2% copper sulfate, and (e) 0.1 % zinc sulfate to be applied twice-daily in the affected area. "
5.	Zinc SulfateFDA Link 07/01/2013 - "In this phase III open labeled, multicenter, non-controlled, non-randomized trial, irritant dermatitis in children and adults either due to diaper rash, pityriasis alba and irritant dermatitis (eczema), perioral dermatitis, perleche or intertrigo were administered; repairing cream RV 2427 B containing a) 4 % zinc oxide, b) 2.5 % dry colloidal oat extract, (c) 0.5 % oat oil, (d) 0.2% copper sulfate, and (e) 0.1 % zinc sulfate to be applied twice-daily in the affected area. "
6.	Disinfectants (Biocides)IBA 02/01/2004 - "Most studies concerned treatments with antifungals or disinfectants in heterogeneous research samples, with only small subsamples of people with intertrigo. "
7.	Amphotericin B (Amphotericin)FDA LinkGeneric 12/01/1965 - "Amphotericin B lotion in monilial intertrigo: a double-blind paired comparison study."
8.	potashIBA 01/01/1986 - "The purpose of this study was to determine the clinical, epidemiological and evolutive characteristics of interdigital and plantar intertrigo of the feet among people working in a coking plant, a potash mine and a motorcar factory. "
9.	Anti-Bacterial Agents (Antibiotics)IBA 09/01/2006 - "All reported episodes of intertrigo of local skin-folds in the preceding years, managed by local care and antibiotics. " 10/20/2000 - "Intertriginous changes during antibiotic treatment may not be due to Candida intertrigo, which is fairly common, but to a prognostically much more important drug reaction." 01/01/1987 - "Antibiotics were used briefly in a few cases where there was intertrigo with skin maceration at acutely flexed PIP joints. " 12/01/2015 - "In multivariate analysis, LE grades III and IV were associated with chronic intertrigo, after adjusting for tingling and numbness, prophylactic antibiotic, age group, and gender. " 08/01/2017 - "Clinicians should consider the treatment of modifiable risk factors including leg oedema, wounds, ulcers, areas of skin breakdown and toe-web intertrigo while administering antibiotic treatment for NPLC."
10.	Nystatin (Mycostatin)FDA LinkGeneric 11/01/1954 - "[Treatment of some dermatoses caused by yeast fungi (moniliasis of the pyodermitis vegetans type, intertrigo, onyxis and perionyxis) with the new fungicide: mycostatin or nystatin]." 01/01/2018 - "Medical treatment of candidal intertrigo usually requires topical administration of nystatin and azole group antifungals. " 05/01/2015 - "Candidal intertrigo are topically treated with nystatin, but azoles or ciclopirox olamine are also suitable candidates. " 01/01/2022 - "Six (46.15%) patients were treated initially by oncology with topical (nystatin, econazole, or clotrimazole) or systemic antifungals (fluconazole) for median (range) of 3.5 (1-7) months without improvement, for presumed candida intertrigo. "

Therapies and Procedures

1.	Mammaplasty (Breast Reconstruction) 07/13/2010 - "There is weak evidence that reduction mammaplasty may be helpful to treat inframammary intertrigo. " 04/01/2008 - "Conclusions based on the medical literature regarding volume of reduction, symptom presentation, conservative therapy, obesity, presence of bra strap grooving and intertrigo, and age at time of reduction were formulated, and these conclusions were compared with the criteria of 90 different health insurance reduction mammaplasty medical policies. " 01/01/1993 - "Reduction mammoplasty can provide relief from shoulder grooving, back and neck pain, intertrigo, and symptoms of ulnar nerve compression. " 01/01/2010 - "In patients with macromastia, the currently accepted indications for reduction mammaplasty are back pain, neck pain, shoulder grooving, and intertrigo in the inframammary fold. " 05/01/2001 - "Reduction mammaplasty was associated with a statistically significant improvement in physical signs and symptoms involving shoulder pain (RD, 0.71 [95% confidence interval (CI), 0.62-0.80]); shoulder grooving (RD, 0.69 [95% CI, 0.60-0.78]); upper/lower back pain (RD, 0.59 [95% CI, 0.48-0.70]); neck pain (RD, 0.50 [95% CI, 0.37-0.64]); intertrigo (RD, 0.44 [95% CI, 0.34-0.54]); breast pain (RD, 0.36 [95% CI, 0.17-0.55]); headache (RD, 0.28 [95% CI, 0.11-0.46]); and pain/numbness in the hands (RD, 0.11 [95% CI, 0.04-0.18]). "
2.	Home Nursing (Nursing, Home) 01/01/2019 - "Aim of this study was to measure the prevalence of intertrigo in aged nursing home residents and to identify possible relationships with demographic and health characteristics. " 01/01/2019 - "Prevalence and associated factors of intertrigo in aged nursing home residents: a multi-center cross-sectional prevalence study." 01/01/2024 - "Older nursing home residents are prone to develop different skin conditions at the same time, including xerosis cutis, skin tears, pressure ulcers, incontinence-associated dermatitis or intertrigo. " 05/01/2023 - "Prevalence and associations of xerosis cutis, incontinence-associated dermatitis, skin tears, pressure ulcers, and intertrigo in aged nursing home residents: A representative prevalence study."
3.	Protective Gloves 06/20/1992 - "Despite the high rates of dermatoses found in a study of 686 female workers in a canning factory in March 1990, use of protective gloves was extremely low, even though there was evidence that they prevented acute paronychia and intertrigo. "
4.	Traditional Medicine (Folk Remedies) 11/25/2022 - "During a previous study that identified plants used in traditional medicine in Togo to treat infectious diseases, Daniellia oliveri was specifically reported to treat intertrigo and candidiasis. "
5.	Therapeutics 02/01/2020 - "We report an unusual case of superficial intertrigo resistant to conventional therapies caused by Mucor circinelloides in a patient with HIV and diabetes." 02/01/2018 - "Consequently, a cultural examination with antibiogram is required to identify the causative agent of intertrigo and guide antimicrobial therapy." 04/01/2016 - "These data have important implications for resistant cases of candidal intertrigo where traditional therapies have failed." 01/01/1999 - "Interdigital intertrigo of the feet due to therapy-resistant Fusarium solani." 11/01/1992 - "It is suggested that drug reactions should be considered in the differential diagnosis of intertrigo, in particular of atypical and therapy-resistant cases. "