Intermediate Filament Proteins

Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.

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Networked: 248 relevant articles (3 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pekny, Milos: 7 articles (04/2014 - 05/2004)
2.	Wilhelmsson, Ulrika: 6 articles (04/2014 - 05/2004)
3.	Omary, M Bishr: 3 articles (12/2015 - 03/2005)
4.	Pekna, Marcela: 3 articles (04/2014 - 05/2004)
5.	Worman, Howard J: 3 articles (01/2013 - 02/2004)
6.	Li, Lizhen: 3 articles (10/2007 - 05/2004)
7.	Kwan, Raymond: 2 articles (12/2015 - 07/2013)
8.	Skalli, Omar: 2 articles (03/2015 - 10/2013)
9.	Coulombe, Pierre A: 2 articles (02/2013 - 11/2012)
10.	Hobbs, Ryan P: 2 articles (02/2013 - 11/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1982 - "It is concluded that the immunohistochemical analysis of intermediate filament proteins has diagnostic potential in clinical pathology and may help to elucidate histogenesis and differentiation of tumors and possibly also prognosis of tumor growth. " 01/01/1985 - "Intermediate filament proteins in the study of tumor heterogeneity: an in-depth study of tumors of the urinary and respiratory tracts." 11/16/2012 - "These findings have broad implications for understanding the role of Akt signaling and intermediate filament proteins in autophagy and cancer." 07/01/2002 - "Tumors with exclusive nuclear p53 contained none or only one of these intermediate filament proteins. " 06/01/2002 - "These results document distinctive patterns of intermediate filament proteins in GI mesenchymal tumors. "
2.	Carcinoma (Carcinomatosis) 01/01/1985 - "However, more recent studies have indicated that at least some neuroendocrine skin carcinomas could in fact coexpress both aforementioned classes of intermediate filament proteins. " 11/01/1994 - "These results indicate that mammary gland carcinomas of both species share a heterogeneous immunophenotype with respect to intermediate filament proteins, which adds to the list of known similarities between mammary gland carcinomas of both species." 09/01/1988 - "Intermediate filament proteins in spindle cell carcinoma of the larynx and tongue." 05/01/1985 - "Intermediate filament proteins of normal epithelia of the human and the bovine male urogenital tract and of certain human renal and bladder carcinomas have been studied by immunofluorescence microscopy and by two-dimensional gel electrophoresis of cytoskeletal fractions from microdissected tissue samples. " 03/01/1984 - "Intermediate filament proteins have been isolated from ME-180, cells of a human cervical carcinoma. "
3.	Gliosis 06/01/2005 - "Particular emphasis is placed on the lessons learnt from mouse genetic models in which the absence of intermediate filament proteins in astrocytes leads to attenuation of reactive gliosis with distinct pathophysiological and clinical consequences." 01/01/2015 - "It is typically assumed that photoreceptor loss leads to an upregulation of glial fibrilliary acidic protein (Gfap) and other intermediate filament proteins, together with other gliosis-related changes, including loss of integrity of the outer limiting membrane (OLM) and deposition of proteoglycans. " 04/17/2014 - "A well- known feature of astrocyte activation and reactive gliosis are the increased production of intermediate filament proteins (also known as nanofilament proteins) and remodeling of the intermediate filament system of astrocytes. " 12/01/2005 - "Neuronal intermediate filament inclusion disease (NIFID) is a new neurodegenerative disease characterized histologically by the presence of neuronal cytoplasmic inclusions (NI) immunopositive for intermediate filament proteins, neuronal loss, swollen achromatic neurons (SN), and gliosis. " 01/01/2010 - "Adult mice lacking the intermediate filament proteins GFAP and vimentin (GFAP(-/-)Vim(-/-)) show attenuated reactive gliosis, reduced glial scar formation and improved regeneration of neuronal synapses after neurotrauma. "
4.	Cicatrix (Scar) 12/12/2008 - "Using RT-PCR, Western blotting and immunohistochemistry, we found that the combined treatment reduced the formation of glial scar and cystic cavities through degrading CSPGs molecules and inhibiting intermediate filament proteins. " 01/01/2010 - "Adult mice lacking the intermediate filament proteins GFAP and vimentin (GFAP(-/-)Vim(-/-)) show attenuated reactive gliosis, reduced glial scar formation and improved regeneration of neuronal synapses after neurotrauma. " 01/01/2015 - "The glial scar is composed mainly of reactive astrocytes that overexpress two intermediate filament proteins, glial fibrillary acidic protein (GFAP) and vimentin (VIM). "
5.	Glioma (Gliomas) 11/01/1997 - "Our studies have confirmed the presence of large concentrations of various intermediate filament proteins (IFPs) in glioma tissue compared to normal brain. " 01/01/1994 - "Expression of non-glial intermediate filament proteins in gliomas." 10/01/1982 - "Occurrence of two different intermediate filament proteins in the same filament in situ within a human glioma cell line. " 03/01/1998 - "Human glioma associated intermediate filament proteins: over-expression, co-localization and cross-reactivity." 08/01/1988 - "To investigate the expression of intermediate filament proteins of the S-phase cells in human glial tumors, we have examined fourteen patients with benign and malignant gliomas by immunohistochemical study using in vivo labeling with bromodeoxyuridine (BrdU). "

Related Drugs and Biologics

1.	Vimentin
2.	Monoclonal Antibodies
3.	Keratins (Keratin)
4.	Glial Fibrillary Acidic Protein
5.	nestin (nestin protein)
6.	Antibodies
7.	Desmin
8.	Proteins (Proteins, Gene)
9.	Paraffin
10.	peripherin