Interferon Type I

Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).

Also Known As:

Networked: 1805 relevant articles (41 outcomes, 112 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Akira, Shizuo: 30 articles (05/2015 - 07/2005)
2.	Kalinke, Ulrich: 22 articles (04/2015 - 02/2002)
3.	Cheng, Genhong: 21 articles (02/2015 - 06/2004)
4.	Fujita, Takashi: 19 articles (08/2015 - 06/2002)
5.	García-Sastre, Adolfo: 17 articles (10/2015 - 05/2002)
6.	Diamond, Michael S: 17 articles (05/2015 - 09/2008)
7.	Rönnblom, Lars: 16 articles (06/2015 - 12/2002)
8.	Shu, Hong-Bing: 15 articles (09/2015 - 10/2004)
9.	Chen, Zhijian J: 14 articles (06/2015 - 09/2005)
10.	Yoneyama, Mitsutoshi: 13 articles (08/2015 - 06/2002)

Related Diseases

1.	Infection 09/01/2013 - "Here we show that type I interferons (IFNs) are important in protection against acute influenza A virus infection not only via their antiviral activity but also via their anti-inflammatory activity. " 04/25/1999 - "Thus, type I interferon, as well as IRF-1 and IRF-2, appears to play an important and necessary role in the pathogenesis of, and protection against, VEE infection." 01/01/2011 - "Although both IFNARko and IPS-1ko hepatocytes showed a reduced induction of type I interferons in response to viral infection, only IPS-1-/- cells circumvented cell death from HCV cytopathic effect and significantly improved J6JFH1 replication, suggesting IPS-1 to be a key player regulating HCV replication in mouse hepatocytes. " 07/01/2004 - "A high expression of a Mx gene, a molecular marker of type I interferon(s) (IFN) occurred in the head kidneys of ABV-challenged flounder from Day 1 to Day 7. These results suggest that the non-specific protection against the secondary VHSV infection in flounder was due to IFN(s) induced by the primary ABV infection." 01/01/2014 - "Immune-based therapeutic strategies that specifically induce type I interferon responses are associated with functional cure for both chronic HBV and HCV infections. "
2.	Neoplasms (Cancer) 01/01/2014 - "Moreover, up-regulated expressions of CD40LG and IRF7 may make for improved tumor cytolytic function of CIK(IL-2) through type I interferon signaling. " 03/01/2014 - "Recent studies demonstrated that endogenous type I interferons (type I IFNs) play a role in radiation-mediated anti-tumor immunity by enhancing the ability of dendritic cells to cross-prime CD8(+) T cells. " 01/01/2011 - "In the current studies, we report that activation of type I interferon (IFN) signaling in tumor cells is primarily due to elevated secretion of the type I interferon, IFN-β. " 04/01/2010 - "An earlier study showed that endogenously produced type I interferons (IFN) suppressed tumor growth via their effects on hematopoietic cells rather than through direct effects on tumor cells. " 01/01/2001 - "Recent studies have shown that gene therapy with type I interferon (IFN) in an adenovirus vector is a powerful tool to suppress the growth of human tumors transplanted in immune-deficient mice. "
3.	Multiple Sclerosis 10/17/2014 - "Enhanced in vivo efficacy of a type I interferon superagonist with extended plasma half-life in a mouse model of multiple sclerosis." 01/01/2004 - "Multiple sclerosis (MS) patients treated with type I interferon experience reduced disease activity. " 11/11/2003 - "Carefully conducted large-scale clinical trials have provided strong evidence that type I interferons favorably influence clinical and MRI outcomes in patients with multiple sclerosis. " 02/01/2015 - "Multiple sclerosis-like lesions and type I interferon signature in a patient with RVCL." 08/01/2014 - "How type I interferons work in multiple sclerosis and other diseases: some unexpected mechanisms."
4.	Glioma (Gliomas) 05/01/2013 - "We recently identified a pivotal role for the host type I interferon (IFN) pathway in immunosurveillance against de novo mouse glioma development, especially through the regulation of immature myeloid cells (IMCs) in the glioma microenvironment. " 01/01/2013 - "Resistance to oncolytic myxoma virus therapy in nf1(-/-)/trp53(-/-) syngeneic mouse glioma models is independent of anti-viral type-I interferon." 04/15/2010 - "Sterile alpha motif containing domain 9 is involved in death signaling of malignant glioma treated with inactivated Sendai virus particle (HVJ-E) or type I interferon." 06/15/1994 - "Deletions of the 9p-localized type-I interferon (IFN) genes and adjacent loci often occur during the development of malignant glioma. " 11/01/2004 - "Because glioma cells undergo apoptosis after transfection with the type I interferon (IFN) gene and type I IFNs promote the stimulatory activity of DCs, we hypothesized that transfection of glioma cells with type I IFN genes and provision of DCs would promote particularly effective antitumor activity by both facilitating apoptosis of glioma cells and the presentation of the glioma antigens, thereby inducing specific immune responses against glioma cells. "
5.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/01/2014 - "Gene expression studies of peripheral blood mononuclear cells from patients with systemic lupus erythematosus (SLE) have demonstrated a type I interferon signature and increased expression of inflammatory cytokine genes. " 03/01/2011 - "In view of the significance of the type I interferon pathway in systemic lupus erythematosus (SLE), this study was undertaken to investigate a possible association between SPI1 polymorphisms and SLE. " 01/01/2010 - "Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus." 09/01/2008 - "Several studies by microarray analysis and real-time polymerase chain reaction (RT-PCR) reveal that type I interferon-inducible genes (IFIGs) are implicated in systemic lupus erythematosus (SLE). " 12/01/2006 - "In recent years, the study of systemic lupus erythematosus (SLE) patients has revealed a central role for type I interferon (IFN) in disease pathogenesis. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Interferon-beta
3.	Antigens
4.	Viral Antigens
5.	Interferons
6.	Cytokines
7.	Interferon-alpha (Interferon Alfa)
8.	Interferon-gamma (Interferon, gamma)
9.	Poly I-C
10.	Carbon Monoxide

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Oral Administration
3.	Immunotherapy
4.	Drug Therapy (Chemotherapy)
5.	Intraperitoneal Injections