Interferon Inducers

Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons.

Also Known As:

Networked: 130 relevant articles (6 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ershov, F I: 4 articles (01/2015 - 01/2010)
2.	Romantsov, M G: 3 articles (01/2014 - 01/2013)
3.	Ospel'nikova, T P: 3 articles (09/2013 - 01/2002)
4.	Jefferson, T O: 2 articles (07/2007 - 01/2001)
5.	Tyrrell, D: 2 articles (07/2007 - 01/2001)
6.	De Clercq, E: 2 articles (01/2005 - 10/2001)
7.	Sidwell, Robert W: 2 articles (01/2003 - 01/2003)
8.	Smee, Donald F: 2 articles (01/2003 - 01/2003)
9.	Grigorian, S S: 2 articles (01/2002 - 01/2000)
10.	Dimitrov, Ivan: 1 article (01/2021)

Related Diseases

1.	Infections 04/01/1983 - "Unlike other protozoan interferon inducers, no parasite-dependent IFN production was observed in the pre-patent period of infection; while the most virulent clone induced very high IFN levels, no clear difference in stimulation was noted in the first waves of semi-acute and chronic T. " 02/01/1979 - "Effect of low molecular weight interferon inducers on Trypanosoma equiperdum infection of mice." 02/01/1978 - "Pretreatment with two interferon inducers significantly reduced mortality, but treatment initiated after infection was not effective." 11/01/1974 - "Interferon inducers in therapy of infection with encephalomyocarditis virus in mice. " 11/01/1974 - "Interferon inducers in therapy of infection with encephalomyocarditis virus in mice. "
2.	Neoplasms (Cancer) 07/01/1984 - "The mechanism underlying this tumor suppression by combination of DFMO and interferon inducers is not yet known. " 07/28/1978 - "Virus-infected animals and those bearing various types of malignancies progressively lose the ability to respond to interferon inducers. " 11/01/1972 - "Enhancement of tumor growth rate by interferon inducers." 03/01/1970 - "[Effect of synthetic interferon-inducers on malignant tumors and viral oncogenesis]." 09/01/1987 - "[Combined effect of interferon inducers, radiosensitizing and antineoplastic agents on solid tumors]."
3.	Encephalitis (Encephalitis, Rasmussen) 11/01/1972 - "Interferon inducers were used against vaccinial encephalitis to study the target-organ treatment of neurotropic disease and to correlate interferon levels and the antiviral state following such treatment. " 02/01/2003 - "Interferons, interferon inducers, and interferon-ribavirin in treatment of flavivirus-induced encephalitis in mice." 01/01/2005 - "ampligen); (v) the cloning and expression of interferon-beta, and (vi) its usefulness in the treatment of multiple sclerosis; (vii) the potential of (pegylated) interferon-alpha in the treatment of hepatitis C and (viii) the therapy/prophylaxis of SARS; (ix) the efficacy of interferon (inducers) in the experimental treatment of flavivirus encephalitis and enterovirus myocarditis; and, finally, (x) the role of interferon in the activity shown by S-adenosylhomocysteine inhibitors such as 3-deazaneplanocin A against experimental Ebola virus infections in mice."
4.	Hyperoxia 01/01/1984 - "After the administration of these interferon inducers with or without hyperoxia the increased activity of heme oxygenase and marked reduction of the heme content of microsomes were demonstrated. " 01/01/1984 - "Since cytochrome P-450 and b5 are the major hemoproteins of microsomes and the known source of oxygen-free radical generation, the results obtained in this study appear to indicate that the depression of the hemoprotein of microsomes by the administration of interferon inducers may be largely responsible for the protective effects of these agents against hyperoxia."
5.	Chronic Hepatitis B 10/09/1976 - "Interferon inducers (or exogenous interferon) may be useful for the treatment of chronic hepatitis-B virus infection."

Related Drugs and Biologics

1.	Interferons
2.	Oxygen (Dioxygen)
3.	Free Radicals
4.	Cytochrome P-450 Enzyme System (Cytochrome P450)
5.	Immunologic Factors (Immunomodulators)
6.	Interferon-alpha (Interferon Alfa)
7.	Nucleosides
8.	Interleukin-2 (IL2)
9.	Acetic Acid (Vinegar)
10.	Interferon-beta

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Intermittent Positive-Pressure Ventilation
4.	Immunotherapy