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Insulinoma

A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.

Also Known As:

Adenoma, beta Cell; Adenomas, beta-Cell; Insulinomas; Insulomas; Tumor, beta-Cell; Tumors, beta-Cell; beta Cell Tumor; beta-Cell Adenoma; beta-Cell Adenomas; beta-Cell Tumors; Adenoma, beta-Cell; Insuloma; beta-Cell Tumor

Networked: 3260 relevant articles (76 outcomes, 358 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypoglycemia (Reactive Hypoglycemia)
2.	Neoplasms (Cancer)
3.	Insulinoma
4.	Neoplasm Metastasis (Metastasis)
5.	Gastrinoma

Experts

1.	Reubi, Jean Claude: 20 articles (07/2015 - 05/2003)
2.	Turk, John: 16 articles (05/2014 - 04/2002)
3.	Kwon, Kang-Beom: 16 articles (09/2010 - 05/2003)
4.	Park, Jin-Woo: 16 articles (09/2010 - 05/2003)
5.	Park, Byung-Hyun: 15 articles (09/2010 - 05/2003)
6.	Newgard, Christopher B: 13 articles (10/2015 - 03/2002)
7.	Peschke, Elmar: 13 articles (05/2014 - 09/2002)
8.	Ramanadham, Sasanka: 13 articles (12/2012 - 04/2002)
9.	Christofori, Gerhard: 12 articles (11/2015 - 10/2002)
10.	Bao, Shunzhong: 12 articles (02/2012 - 12/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Insulinoma:

1.	Insulin (Novolin)FDA Link 06/01/2012 - "Consistent with protective effects on insulinoma cells, 2BrP also attenuates the inhibitory actions of prolonged palmitate treatment on insulin secretion by isolated rat islets. " 06/01/2003 - "Selection of insulin-producing rat insulinoma (RINm) cells with improved resistance to oxidative stress." 09/01/1992 - "Investigation of patients with insulinomas and of insulin cells in culture and tissue sections may help to clarify the biological function of IAPP." 09/01/1983 - "This is shown both by the response to improved control in insulin-dependent diabetics and secondly by their changes after insulinoma removal. " 01/16/2014 - "The aim of this study was to gain a better insight into the role of TG2 transamidating activity in mitochondria and in the nucleus of INS-1E rat insulinoma cell line (INS-1E) during insulin secretion. "
2.	Glucose (Dextrose)FDA LinkGeneric 01/01/2014 - "The hypoglycemic symptoms were relieved greatly by glucose administration and Whipple's triad for insulinoma was met. " 03/01/1987 - "After resection of the insulinoma, glycemia in PA was 103 mg/dl, Ra and Rd were increased slightly to 1.9 mg/kg/min while the metabolic clearance of glucose was decreased by 25% (2.1 ml/kg/min). " 10/01/2013 - "In this study, using the BRIN-BD11 rat insulinoma cell line, we i) examined the basal expression levels of components of classical and alternative RAS axes and ii) investigated the effects of normal (5.5 mM) and elevated (11, 15, 25 mM) glucose concentrations on their expression and/or enzymatic activity by means of reverse transcription quantitative PCR (RT-qPCR), immunoblot analysis and enzymatic activity assays. " 02/01/2012 - "Our previous in vitro study demonstrated that glyceollins help normalize glucose homeostasis by potentiating β-cell function and survival in insulinoma cells as well as improving glucose utilization in adipocytes. " 01/27/2012 - "In rat INS-1E insulinoma cells, deletion studies of the rat Gcgr promoter show that ChoRE is a minimal glucose response element. "
3.	Octreotide (Sandostatin)FDA LinkGeneric 05/01/2005 - "Octreotide is an effective treatment of hypoglycaemia in more than 50% of patients with insulinoma. " 03/01/1994 - "Octreotide seems to be a promising treatment for many of the patients with insulinoma who are not suitable for surgery." 06/01/2008 - "A short 100-microg octreotide test correctly predicted the efficacy of treatment in six patients with benign insulinomas. " 05/01/2005 - "Expression of sst5 receptor does not appear to explain per se the efficacy of octreotide on sst2A-negative insulinomas." 03/01/1994 - "The efficacy of octreotide was studied in a group of patients with biochemical evidence of insulinoma. "
4.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 06/01/2008 - "The long-term efficacy of somatostatin analogues on insulinomas has not been studied. " 07/01/2014 - "Somatostatin analog inhibits the growth of insulinoma cells by p27-mediated G1 cell cycle arrest." 01/01/2013 - "Metastatic insulinoma managed with radiolabeled somatostatin analog." 02/01/2012 - "Effective therapy of insulinoma by using long-acting somatostatin analogue. " 01/01/2012 - "Malignant insulinomas, in contrast to their benign counterparts, express GLP-1R in only one-third of the cases, while they more often express the somatostatin type 2 receptors. "
5.	CalciumIBA 02/20/1991 - "A newly described test involving calcium infusion, 2 mg/kg in one minute, seems to give a diagnostic response in most patients with insulinomas, few false positive results and few side effects. " 01/01/2014 - "Low concentrations of calcium are effective and safe when performing SACST for localization of insulinoma." 04/01/1998 - "Objective is to evaluate the efficacy of the intraarterial calcium test in the preoperative localisation of insulinomas. " 01/01/2011 - "A CT scan showed 20 mm lesion in the pancreas which was confirmed as insulinoma with pancreatic arterial calcium stimulation studies. " 11/01/2007 - "Six patients with biochemical evidence of an insulinoma underwent pre-operative localisation studies and selective arterial calcium injection (SACI). "
6.	Diazoxide (Hyperstat)FDA Link 12/01/2015 - "Insulinomas have only rarely been documented in guinea pigs and one animal was effectively treated with diazoxide. " 10/01/1997 - "We conclude that diazoxide is effective in the management of insulinoma. " 02/15/2013 - "This case demonstrates that diazoxide treatment can help achieve euglycemia in hypoglycemic guinea pigs and is a potential treatment option for guinea pigs with insulinoma." 02/15/2013 - "Diazoxide treatment for presumptive insulinoma was started at a dosage of 5 mg/kg (2.3 mg/lb), p.o., every 12 hours. " 01/01/2009 - "She was commenced on diazoxide and later underwent surgery for enucleation of insulinoma when a small (< 1 cm) incidental tumour was discovered on her stomach wall which was identified as GIST. "
7.	HormonesIBA 04/01/2004 - "In this study, we investigated the effects of exposure to an extremely low frequency magnetic field (ELFMF) on hormone secretion from an islet derived insulinoma cell line, RIN-m. " 09/01/1993 - "To study whether the responsiveness of islet cells to these hormones is regulated on the receptor level, GH and PRL receptor gene expression was studied in pancreata from male rats and virgin, pregnant, and lactating female rats and in cultured islets and insulinoma cells (RIN-5AH) in response to various hormones. " 06/12/2015 - "A significant portion of human and rat insulinomas coexpress multiple hormones. " 03/01/2009 - "Immunohistochemistry and RT-PCR were used to examine hormone and gene expression, respectively, by insulinoma cells. " 06/01/2007 - "Insulinomas are the most common hormone-producing pancreatic neuroendocrine tumours (NETs), and patients usually present with symptoms secondary to hypoglycaemia. "
8.	everolimus FDA Link 02/01/2014 - "Everolimus dramatically improves glycemic control in unresectable metastatic insulinoma: a case report." 01/01/2014 - "Intermittent everolimus administration for malignant insulinoma." 05/01/2013 - "Long-term maintenance of normoglycaemia using everolimus in a patient with disseminated insulinoma and severe hypoglycaemia." 05/01/2010 - "Lutetium-177 octreotate and everolimus are options for managing hypoglycaemia due to unresectable malignant insulinoma when refractory to conventional supportive therapies." 01/01/2010 - "To investigate the effect of immunosuppression agent Everolimus on the viability and function of insuloma cells (INS-1) and pancreatic islet cells cultured in vitro. "
9.	Ethanol (Ethyl Alcohol)IBA 09/01/2014 - "EUS-guided ethanol ablation of insulinomas is an effective and safe modality, with an acceptable level of post-procedural complications. " 01/01/2012 - "US-guided ethanol ablation of insulinomas: a new treatment option." 07/01/2008 - "We wanted to evaluate the feasibility, safety and efficacy of ethanol injection using endoscopic ultrasound (EUS) guidance to ablate a pancreatic insulinoma. " 12/01/2015 - "EUS-guided ethanol ablation of symptomatic pancreatic insulinomas." 07/01/2015 - "A recent emergence of minimally invasive treatment modalities has led to reports of successful radiofrequency and ethanol ablation of insulinomas. "
10.	Somatostatin Receptors (Somatostatin Receptor)IBA 03/01/2000 - "The aim of this study was to determine whether the systematic use of SPECT can increase the reported low sensitivity of somatostatin receptor scintigraphy (SRS) in detecting insulinomas. " 06/01/2015 - "In case of benign insulinoma the density of those receptors is even higher than the density of somatostatin receptors. " 02/01/2015 - "Although somatostatin receptor imaging has a limited role in the visualization of benign insulinoma (characterized by a low expression of somatostatin receptors), it can still have a role in the detection of malignant forms. " 09/01/2012 - "After biochemical test showing probable insulinoma, somatostatin receptor scintigraphy showed a focal captation in head and body of pancreas. " 06/01/2007 - "Selective angiography and somatostatin-receptor scintigraphy did not reveal insulinoma. "

Therapies and Procedures

1.	Pancreatectomy 01/01/2000 - "Preoperative ASVS can accurately localize an insulinoma, and may help to increase the success rate of surgery and avoid blind pancreatectomy." 06/01/2002 - "Blind distal pancreatectomy has been advocated for occult insulinomas not detected on imaging studies or during abdominal exploration. " 08/01/2015 - "Between August 2007 and September 2014, 15 consecutive patients with biochemical evidence of an insulinoma underwent laparoscopic pancreatectomy. " 08/01/2015 - "If preoperative localization of the insulinoma is completed, enucleation from the pancreatic body or tail, and distal pancreatectomy can be performed safely by laparoscopy. " 03/01/2015 - "None of the 6 have undergone pancreatectomy, and none have evidence of insulinoma. "
2.	Drug Therapy (Chemotherapy) 11/01/2000 - "Locoregional therapy for insulinoma metastatic to the liver might represent the treatment of choice; hepatic intra-arterial chemotherapy is an interesting therapeutic approach which deserves attention. " 02/01/1984 - "This patient has survived 17 years with a malignant insulinoma and without islet-cell chemotherapy. " 12/01/2013 - "We herein present the case of a 5-year survivor with insulinoma after complete response of postoperative liver metastases to hepatic arterial infusion combined with systemic chemotherapy. " 12/01/2013 - "Hepatic arterial infusion combined with systemic chemotherapy induced complete response of metachronous liver metastases after resection of pancreatic insulinoma." 05/27/1995 - "We report two cases of malignant insulinomas with liver metastases for which objective responses were obtained with combination of local treatment and intravenous chemotherapy."
3.	Transplantation (Transplant Recipients) 04/01/2000 - "Engineered insulinoma cell lines may represent an alternative to isolated islets for transplantation therapy of type 1 diabetes. " 01/01/1999 - "Use of insulinoma cells, which can be amplified in culture, relaxes the tissue availability limitation that exists with normal pancreatic islet transplantations. " 09/01/1996 - "This experiment was designed to investigate whether MIN6-cells, which are derived from transgenic mouse insulinoma cells, could be a useful tool for transplantation. " 10/01/1986 - "subscapular transplantation of a radiation-induced insulinoma, male NEDH rats exhibited hyperinsulinaemia and hypoglycaemia. " 01/01/1986 - "The results demonstrate an important effect of transplantation site on the function and metabolic consequences of the NEDH rat insulinoma."
4.	Aftercare (After-Treatment) 08/01/2001 - "Interestingly, STZ-treated APNG(-/-) mice succumbed to diabetes 8 months after treatment, in contrast to previous work with PARP inhibitors, where a high incidence of beta-cell tumors was observed. " 06/01/2007 - "We describe a case of a patient with a metastatic NET, subsequently identified as a malignant insulinoma, who developed severe hypoglycaemia after treatment with long-acting octreotide." 04/01/2006 - "After treatment with baicalin, the number of cells in mitotic stage and the survival rate of cells obviously decreased, and cell proliferation was inhibited in a drug concentration- and acting time-dependent manner, with the appearance of apoptotic insulinoma cells. " 04/01/1987 - "Most importantly, RT1.B antigens were newly expressed by rat insulinoma cells in vitro after treatment with rIF gamma. " 03/01/2013 - "Various types of cells were used in this study: mouse preadipocytes (3T3-L1), prechondrocytes (ATDC5), myoblasts (C2C12), mesenchymal stromal cells (KUSA-A1), lung cancer cells (LLC), insulinoma cells (MIN6), fibroblasts (NIH-3T3), human cervix adenocarcinoma cells (HeLa), macrophages differentiated from lymphocytes (THP-1) after treatment with phorbol ester, and rat basophilic leukemia cells (RBL-2H3). "
5.	Radiotherapy 01/01/2015 - "In this study we have investigated the organ distribution of [(177)Lu]-DO3A-VS-Cys(40)-Exendin-4 in rat and calculated human dosimetry parameters in order to estimate the maximal acceptable administered radioactivity, and thus potential applicability of [(177)Lu]-DO3A-VS-Cys(40)-Exendin-4 for internal radiotherapy of insulinomas. " 01/01/2015 - "Dosimetry of [(177)Lu]-DO3A-VS-Cys(40)-Exendin-4 - impact on the feasibility of insulinoma internal radiotherapy." 06/15/2007 - "We have previously shown that the high density of glucagon-like peptide-1 receptors (GLP-1R) in human insulinoma cells provides an attractive target for molecular imaging and internal radiotherapy. " 04/01/1985 - "Subcutaneous infusion of glucagon by portable pump appears to give very effective symptomatic relief from non beta cell tumor hypoglycemia when surgery, radiotherapy and chemotherapy are impossible or ineffective. " 01/01/2013 - "Herein, we present a resistant case of inoperable malignant insulinoma who was treated with many therapeutic agents and interventions including somatostatin analogues, Yttrium-90 radioembolization, everolimus, radiotherapy, and chemoembolization. "