Insulinoma

A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.

Also Known As:

Adenoma, beta Cell; Adenomas, beta-Cell; Insulinomas; Insulomas; Tumor, beta-Cell; Tumors, beta-Cell; beta Cell Tumor; beta-Cell Adenoma; beta-Cell Adenomas; beta-Cell Tumors; Adenoma, beta-Cell; Insuloma; beta-Cell Tumor

Networked: 4596 relevant articles (146 outcomes, 511 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypoglycemia (Reactive Hypoglycemia)
2.	Neoplasms (Cancer)
3.	Insulinoma
4.	Neoplasm Metastasis (Metastasis)
5.	Primitive Neuroectodermal Tumors (PNET)

Experts

1.	Wild, Damian: 23 articles (06/2022 - 12/2006)
2.	Reubi, Jean Claude: 23 articles (09/2020 - 05/2003)
3.	Newgard, Christopher B: 16 articles (01/2021 - 03/2002)
4.	Turk, John: 16 articles (05/2014 - 04/2002)
5.	Kwon, Kang-Beom: 16 articles (09/2010 - 05/2003)
6.	Park, Jin-Woo: 16 articles (09/2010 - 05/2003)
7.	Christ, Emanuel: 15 articles (06/2022 - 08/2008)
8.	Park, Byung-Hyun: 15 articles (09/2010 - 05/2003)
9.	Peschke, Elmar: 13 articles (05/2014 - 09/2002)
10.	Ramanadham, Sasanka: 13 articles (12/2012 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Insulinoma:

1.	Glucose (Dextrose)FDA LinkGeneric 06/23/2021 - "In particular, the report highlights the first documented use of flash glucose monitoring in insulinoma, which was beneficial in reducing the discomfort of lancet use and anxiety associated with hypoglycaemic episodes. " 03/01/1987 - "After resection of the insulinoma, glycemia in PA was 103 mg/dl, Ra and Rd were increased slightly to 1.9 mg/kg/min while the metabolic clearance of glucose was decreased by 25% (2.1 ml/kg/min). " 01/01/2023 - "In this study, we show that MRPS6 but not SLC5A3 regulates glucose-stimulated insulin secretion (GSIS) in primary human β-cell and a mouse pancreatic insulinoma β-cell line. " 01/01/2021 - "In high glucose-challenged human islets and rat insulinoma cells overexpressing hIAPP, cell fractionation studies revealed increased accumulation of hIAPP. " 10/01/2019 - "The purpose of this study was to evaluate the pancreatic beta cell protective and glucose uptake enhancing effect of the water extract of Tinospora cordifolia stem (TCSE) by using rat insulinoma (RIN)-m5F cells and 3 T3-L1 adipocytes. "
2.	Insulin (Novolin)FDA Link 06/01/2003 - "Selection of insulin-producing rat insulinoma (RINm) cells with improved resistance to oxidative stress." 09/01/1992 - "Investigation of patients with insulinomas and of insulin cells in culture and tissue sections may help to clarify the biological function of IAPP." 09/01/1983 - "This is shown both by the response to improved control in insulin-dependent diabetics and secondly by their changes after insulinoma removal. " 01/24/2023 - "In this study, we investigated whether chronic exposure to ketohexoses causes glucotoxicity, suppression of insulin gene expression, and apoptosis, in INS-1 rat pancreatic insulinoma cells. " 01/01/2023 - "In this study, an in vitro culture system of rat insulinoma (INS-1) cells was established to explore the effect of DBP on insulin synthesis and secretion and the potential mechanisms. "
3.	Octreotide (Sandostatin)FDA LinkGeneric 05/01/2005 - "Octreotide is an effective treatment of hypoglycaemia in more than 50% of patients with insulinoma. " 03/01/1994 - "Octreotide seems to be a promising treatment for many of the patients with insulinoma who are not suitable for surgery." 06/01/2008 - "A short 100-microg octreotide test correctly predicted the efficacy of treatment in six patients with benign insulinomas. " 05/01/2005 - "Expression of sst5 receptor does not appear to explain per se the efficacy of octreotide on sst2A-negative insulinomas." 03/01/1994 - "The efficacy of octreotide was studied in a group of patients with biochemical evidence of insulinoma. "
4.	CalciumIBA 10/01/2020 - "The selective arterial calcium stimulation test (SACST) is one of the most useful localization tests for insulinoma but can cause false-positive and/or unexpected multi arterial positive results that hamper clinical decisions. " 02/01/1997 - "Although calcium provocation-angiography is highly effective in the identification of insulinomas, it is significantly more invasive and should be used only as a last resort. " 02/20/1991 - "A newly described test involving calcium infusion, 2 mg/kg in one minute, seems to give a diagnostic response in most patients with insulinomas, few false positive results and few side effects. " 09/25/2020 - "Selective arterial calcium stimulation and hepatic venous sampling is an effective and safe minimally-invasive procedure for insulinoma localization that may be utilized when non-invasive techniques are inconclusive. " 01/01/2014 - "Low concentrations of calcium are effective and safe when performing SACST for localization of insulinoma."
5.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 06/01/2008 - "The long-term efficacy of somatostatin analogues on insulinomas has not been studied. " 05/01/2019 - "Combination treatment with somatostatin analog and mTOR inhibitor may be another effective approach in inoperable metastatic malignant insulinoma." 12/27/2018 - "A case of malignant insulinoma responsive to somatostatin analogs treatment." 07/01/2014 - "Somatostatin analog inhibits the growth of insulinoma cells by p27-mediated G1 cell cycle arrest." 01/01/2013 - "Metastatic insulinoma managed with radiolabeled somatostatin analog."
6.	Streptozocin (Streptozotocin)FDA Link 02/01/2006 - "We have recently shown that repeated streptozotocin (STZ) treatment induces the selection of insulinoma cells (RINmS) with both improved resistance to diabetogenic toxins and functional activity, compared to parental RINm cells. " 01/01/2010 - "In this study, preventive effects of fermented ginseng (FG) against streptozotocin (STZ)-induced pancreatic beta-cell death was assessed in RINm5F insulinoma cells. " 05/01/2017 - "When overexpressed in insulinoma cells, CCN5 promotes cell proliferation and cell survival against streptozotocin-induced cell death. " 05/01/2013 - "Streptozotocin can be safely administered to dogs with insulinoma, but serious AEs are possible. " 05/01/2013 - "Administration of streptozotocin (STZ) at a 21-day interval has been described in dogs with stage II and III insulinoma. "
7.	Diazoxide (Hyperstat)FDA Link 10/01/2020 - "We report here a case of insulinoma effectively treated with diazoxide, as our report will be helpful for similar cases." 10/01/2020 - "A case of insulinoma effectively treated with low-dose diazoxide." 12/01/2015 - "Insulinomas have only rarely been documented in guinea pigs and one animal was effectively treated with diazoxide. " 10/01/1997 - "We conclude that diazoxide is effective in the management of insulinoma. " 01/10/2023 - "An initial diagnosis of insulinoma was made and she was commenced on diazoxide. "
8.	Ethanol (Ethyl Alcohol)IBA 01/01/2021 - "the treatment of symptomatic insulinoma by endoscopic ultrasound-guided ethanol ablation could be a safe and effective alternative to surgical management in non-surgical patients or those who refuse surgery." 09/01/2014 - "EUS-guided ethanol ablation of insulinomas is an effective and safe modality, with an acceptable level of post-procedural complications. " 01/01/2012 - "US-guided ethanol ablation of insulinomas: a new treatment option." 07/01/2008 - "We wanted to evaluate the feasibility, safety and efficacy of ethanol injection using endoscopic ultrasound (EUS) guidance to ablate a pancreatic insulinoma. " 01/01/2024 - "Ethanol ablation provides an alternative therapeutic option for patients with insulinoma. "
9.	C-PeptideIBA 10/27/2023 - "and C-peptide >270 a.u.) had a sensitivity of 0.96, 0.78 to 1.00, and a specificity of 0.96 or greater (≥0.89-0.99) for insulinoma diagnosis. " 05/01/2023 - "Elevated C-peptide levels in the absence of sulfonylurea use indicate insulinoma. " 07/23/2021 - "Although the C-peptide was detectable, there were no clinical, biochemical or radiological features suggestive of insulinoma. " 11/01/2002 - "In contrast to the situation in rats, des-[27-31]-C-peptide is not a major secretory product of human islets and its contribution to total circulating C-peptide is not increased in Type II diabetes or in patients with insulinoma." 11/01/2002 - "The proportion of total C-peptide immunoreactivity comprised of des-[27-31]-C-peptide was 1.5% or less in all plasma samples, except for that from one patient with insulinoma where it was 4.2%. "
10.	Hormones (Hormone)IBA 04/01/2004 - "In this study, we investigated the effects of exposure to an extremely low frequency magnetic field (ELFMF) on hormone secretion from an islet derived insulinoma cell line, RIN-m. " 09/01/1993 - "To study whether the responsiveness of islet cells to these hormones is regulated on the receptor level, GH and PRL receptor gene expression was studied in pancreata from male rats and virgin, pregnant, and lactating female rats and in cultured islets and insulinoma cells (RIN-5AH) in response to various hormones. " 01/01/2023 - "A portion of metastatic insulinomas were largely derived from non-metastatic insulinomas in hormone secretion and ARX/PDX1 expression patterns. " 10/01/2022 - "This data suggests that the measured size of insulinoma by EUS is not related to the time until termination of the 72-hour fast and measured hormone levels. " 10/01/2022 - "There was no correlation between the duration of fasting, hormone levels, and the size of the insulinoma. "

Therapies and Procedures

1.	Therapeutics 03/01/2007 - "These data give strong objective support to the role of medical therapy in the management of canine insulinoma, including following relapse after surgically induced remission." 06/01/2008 - "CGM in insulinoma is useful in detecting hypoglycaemia, and hypoglycaemia unawareness, monitoring response to medical therapy and for confirming cure postoperatively, and is useful in the management of this uncommon but dangerous condition." 01/01/2023 - "This study will ascertain if EUS-RFA can become the first-line therapy for management of small, sporadic, pancreatic insulinoma and be included in a step-up approach in case of clinical failure." 10/01/2017 - "Our study highlights, in particular, the utility of the 48-h fast in the diagnosis of insulinoma, EUS for tumour localisation and the value of PRRT therapy in the treatment of metastatic disease." 09/01/2008 - "Diagnosis of the disease, localisation of the tumour and surgical therapy may be challenging and the aim of this study is to evaluate the problems concerning insulinoma. "
2.	Pancreatectomy 01/01/2017 - "Conclusion: Resection of insulinomas is the preferred approach of treatment, and resection by central pancreatectomy is a safe option for benign lesions in the neck of the pancreas." 01/01/2000 - "Preoperative ASVS can accurately localize an insulinoma, and may help to increase the success rate of surgery and avoid blind pancreatectomy." 06/01/2002 - "Blind distal pancreatectomy has been advocated for occult insulinomas not detected on imaging studies or during abdominal exploration. " 07/01/2023 - "Although insulinoma is mostly benign, conservative surgery such as enucleation or partial pancreatectomy is usually the cornerstone of treatment. " 10/25/2022 - "Retrospective review of medical records of dogs undergoing partial pancreatectomy as treatment for insulinoma. "
3.	Radiofrequency Ablation 01/01/2020 - "Our study suggests laparoscopic radiofrequency ablation could be developed as a safe and effective alternative treatment to surgery for the patients with insulinomas who refuse or are not eligible for surgery." 12/01/2020 - "Endoscopic ultrasound-guided radiofrequency ablation: An effective and safe alternative for the treatment of benign insulinoma." 08/01/2023 - "Safety and efficacy of endoscopic ultrasound-guided radiofrequency ablation for pancreatic insulinoma: A single-center experience." 01/01/2023 - "Study protocol for a multicenter randomized controlled trial to compare radiofrequency ablation with surgical resection for treatment of pancreatic insulinoma." 10/20/2023 - "Long-term clinical and radiological outcomes of endoscopic ultrasound-guided radiofrequency ablation of benign insulinomas."
4.	Drug Therapy (Chemotherapy) 01/01/2018 - "In the present work, we studied the tumorigenicity of Nfe2l1-deficient insulinoma MIN6 cells (Nfe2l1-KD) and sensitivity to chemotherapy. " 02/01/1984 - "This patient has survived 17 years with a malignant insulinoma and without islet-cell chemotherapy. " 11/01/2000 - "Locoregional therapy for insulinoma metastatic to the liver might represent the treatment of choice; hepatic intra-arterial chemotherapy is an interesting therapeutic approach which deserves attention. " 12/01/2013 - "We herein present the case of a 5-year survivor with insulinoma after complete response of postoperative liver metastases to hepatic arterial infusion combined with systemic chemotherapy. " 12/01/2013 - "Hepatic arterial infusion combined with systemic chemotherapy induced complete response of metachronous liver metastases after resection of pancreatic insulinoma."
5.	Aftercare (After-Treatment) 06/01/2007 - "We describe a case of a patient with a metastatic NET, subsequently identified as a malignant insulinoma, who developed severe hypoglycaemia after treatment with long-acting octreotide." 04/01/2006 - "After treatment with baicalin, the number of cells in mitotic stage and the survival rate of cells obviously decreased, and cell proliferation was inhibited in a drug concentration- and acting time-dependent manner, with the appearance of apoptotic insulinoma cells. " 08/01/2001 - "Interestingly, STZ-treated APNG(-/-) mice succumbed to diabetes 8 months after treatment, in contrast to previous work with PARP inhibitors, where a high incidence of beta-cell tumors was observed. " 04/01/1987 - "Most importantly, RT1.B antigens were newly expressed by rat insulinoma cells in vitro after treatment with rIF gamma. " 06/01/1976 - "Three weeks after treatment marked alterations in glucose tolerance were noted in animals which later exhibited large beta cell tumors. "