Insulysin (Insulin-Degrading Enzyme)

An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.

Also Known As:

Networked: 152 relevant articles (6 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Leissring, Malcolm A: 10 articles (03/2013 - 12/2003)
2.	Morelli, Laura: 8 articles (01/2009 - 06/2003)
3.	Tang, Wei-Jen: 7 articles (01/2015 - 08/2007)
4.	Castaño, Eduardo M: 7 articles (01/2009 - 12/2004)
5.	Selkoe, Dennis J: 5 articles (01/2009 - 04/2003)
6.	Prince, Jonathan A: 5 articles (09/2007 - 11/2003)
7.	Ciaccio, Chiara: 4 articles (01/2015 - 02/2009)
8.	van Endert, Peter: 4 articles (01/2015 - 05/2010)
9.	Qiu, Wei Qiao: 4 articles (01/2014 - 02/2006)
10.	Hersh, Louis B: 4 articles (01/2011 - 05/2003)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 03/04/2015 - "Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer's disease." 06/01/2015 - "The insulin-degrading enzyme (IDE) gene is a strong positional and biological candidate for late-onset Alzheimer disease (LOAD) susceptibility, with recent studies independently demonstrating an association between IDE gene variants and LOAD. " 06/01/2007 - "In this study we report that the membrane-bound, but not cytosolic insulin degrading enzyme (IDE) protein concentration and IDE activity are significantly decreased in the hippocampal formation of cases affected by mild cognitive impairment (MCI) which are at high risk to develop Alzheimer's disease (AD), relative to normal neurological controls. " 07/05/2005 - "Genetic and biological studies point to a role for insulin-degrading enzyme (IDE) in Alzheimer's disease (AD). " 07/05/2005 - "Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme."
2.	Amyloid Plaque 01/01/2015 - "Incubation of fresh slices for 2 weeks with 1-0.1-0.01 μg/ml of NEP, insulysin, MMP-2, or MMP-9 showed that NEP, insulysin, and MMP-9 markedly degraded beta-amyloid plaques but only at the highest concentration. " 01/01/2005 - "The insulysin-dependent cleavage of A(beta) prevents both the neurotoxic effects of the peptide as well as the ability of A(beta) to deposit onto synthetic amyloid plaques. " 03/01/2007 - "It is suggested that the granulomas were the source of an insulin-degrading enzyme (IDE) which simultaneously degraded amyloidogenic precursors into localized amyloid deposits. " 03/26/1999 - "Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques." 09/02/2011 - "TLJN can improve learning and memory, up-regulate insulin-degrading enzyme and neprilysin levels, promote the degrading of Aβ and clear amyloid plaque from the AD rat brain. "
3.	Dementia (Dementias) 03/04/2015 - "The precursor protein BRI2 that in its mutated form is associated with British and Danish dementia, can regulate critical processes involved in AD pathogenesis including not only the metabolism of amyloid precursor protein (APP) and formation of Aβ, but also the levels of secreted insulin degrading enzyme (IDE), an enzyme involved in Aβ clearance. " 01/01/2008 - "Insulin degrading enzyme (IDE) degrades amyloid beta (Abeta), which may inhibit the accumulation of Abeta in a brain affected with dementia of Alzheimer's type (DAT). " 01/01/2006 - "Insulin-degrading enzyme (IDE) polymorphism is hypothesized to regulate insulin levels as well as processes involved in neuronal compromise found in dementia. " 01/01/2006 - "Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk." 06/27/2003 - "Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme."
4.	Diabetes Mellitus 01/01/1987 - "[Blood insulinase activity in patients with diabetes mellitus]." 05/01/1964 - "[THE ROLE OF INSULINASE IN THE PATHOGENESIS OF DIABETES MELLITUS]." 01/01/1957 - "The role of insulinase and insulinase-inhibitors in the etiology of diabetes mellitus in man." 01/01/1957 - "Insulinase, insulinase-inhibitors, and diabetes mellitus." 01/01/1956 - "The hypoglycemic action of insulinase-inhibitors by mouth in patients with diabetes mellitus."
5.	Liver Cirrhosis (Hepatic Cirrhosis) 02/01/2004 - "This study was to detect the dynamical effects and mechanisms of CS on the activity of hepatic insulinase in CCl4 induced liver cirrhosis in rats. " 01/01/1976 - "Insulinase in liver cirrhosis." 01/01/1994 - "To investigate whether insulin degradation is impaired in cirrhotic liver, the specific insulin-degrading enzyme activity (EC 3.4.22.11) was assayed in liver cytosol of rats with CCl4-induced liver cirrhosis. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Amyloid beta-Peptides
3.	Amyloid (Amyloid Fibrils)
4.	Neprilysin (Neutral Endopeptidase)
5.	Peptide Hydrolases (Proteases)
6.	Matrix Metalloproteinases
7.	Apolipoproteins
8.	Apolipoproteins E (ApoE)
9.	Glucose (Dextrose)
10.	tongluo