Inositol (Myoinositol)

An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.

Also Known As:

Networked: 2012 relevant articles (80 outcomes, 222 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Belmaker, R H: 11 articles (04/2015 - 02/2000)
2.	Baillargeon, Jean-Patrice: 9 articles (04/2010 - 11/2002)
3.	Unfer, Vittorio: 8 articles (10/2014 - 12/2007)
4.	Carlomagno, Gianfranco: 6 articles (12/2015 - 06/2011)
5.	Berry, Gerard T: 6 articles (03/2014 - 05/2003)
6.	Nestler, John E: 6 articles (04/2010 - 11/2002)
7.	Ostlund, Richard E: 6 articles (01/2009 - 02/2006)
8.	De Leo, V: 5 articles (10/2015 - 02/2013)
9.	Cappelli, V: 5 articles (10/2015 - 02/2013)
10.	Nelson, Sarah J: 5 articles (05/2015 - 11/2010)

Related Diseases

1.	Panic Disorder (Panic Attack) 07/01/1995 - "Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder. " 07/01/1995 - "The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder." 07/01/1997 - "Chronic inositol had previously shown efficacy against panic disorder. " 06/01/2001 - "Continuing reports of inositol's efficacy in the treatment of depression, panic disorder, and OCD should stimulate replication studies." 01/01/2001 - "Clinical controlled trials of inositol in patients with depression, panic disorder, and OCD were small, and positive psychoactive effects in animals clearly strengthen the case for further clinical trials and potential for general therapeutic use in humans."
2.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 09/01/1996 - "Thirteen patients with obsessive-compulsive disorder completed a double-blind, controlled crossover trial of 18 g/day of inositol or placebo for 6 weeks each. " 01/01/2002 - "Defining the neuromolecular action of myo-inositol: application to obsessive-compulsive disorder." 09/01/1996 - "Inositol treatment of obsessive-compulsive disorder." 06/01/2004 - "Single photon emission computed tomography (SPECT) in obsessive-compulsive disorder before and after treatment with inositol." 10/01/1998 - "myo-Inositol has been found to be clinically effective in depression, obsessive compulsive disorder (OCD) and panic disorder when given chronically per os. "
3.	Bipolar Disorder (Mania) 04/01/2006 - "There was a trend for more subjects on inositol to show improvement in bipolar depression symptoms, but, on average, inositol was not more effective than placebo as an adjunct for bipolar depression. " 05/01/2011 - "Inositol may be useful in the treatment of bipolar depression when combined with mood stabilizers. " 04/01/2006 - "This study evaluated the efficacy of adjunctive inositol for bipolar depression. " 03/01/2000 - "These pilot data suggest a controlled study with an adequate sample size, and the appropriate rating scale may demonstrate efficacy for inositol in bipolar depression. " 01/01/2013 - "Limited evidence found that inositol may be helpful for bipolar depression, but larger sample sizes are needed. "
4.	Insulin Resistance 08/01/2015 - "Furthermore, women treated with myo-inositol showed a significantly greater reduction in the homeostasis model assessment of insulin resistance compared with the control group, -1.0±3.1 compared with 0.1±1.8 (P=.048). " 01/01/2011 - "Presumably a substitution therapy with exogenous Myo-inositol could be effective for treatment of insulin resistance and PCOS. " 06/28/2015 - "In addition, some abnormalities in inositol metabolism were reported to be associated with insulin resistance in several animal and human studies. " 01/01/2015 - "In this study, we show that skeletal muscle kidney-enriched inositol polyphosphate phosphatase (SKIP), a PIP3 (phosphatidylinositol-3,4,5-trisphosphate) phosphatase, links ER stress to insulin resistance in skeletal muscle. " 08/01/2015 - "Myo-inositol supplementation, started in the first trimester, in obese pregnant women seems to reduce the incidence in GDM through a reduction of insulin resistance. "
5.	Neoplasms (Cancer) 01/01/2006 - "Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP(6) + inositol holds great promise in our strategies for cancer prevention and therapy. " 01/01/2006 - "Protection against cancer by dietary IP6 and inositol." 10/01/2008 - "These studies indicate that MMP and PA activities play a role in sex accessory gland tumor biology and that dietary supplementation with myo-inositol can delay but not ultimately prevent the development of such tumors." 06/10/2001 - "Dietary myo-inositol is an effective inhibitor of lung tumor induction in mice, but no dose-response studies have been reported. " 01/01/2015 - "Real-time qPCR analysis suggested Hic1 (hypermethylated in cancer 1), Inpp5k (inositol polyphosphate-5-phosphatase K; a.k.a. "

Related Drugs and Biologics

1.	Inositol (Myoinositol)
2.	Glucose (Dextrose)
3.	Lithium
4.	Insulin (Novolin)
5.	Phosphatidylinositols (Phosphatidylinositol)
6.	Folic Acid (Vitamin M)
7.	Smoke
8.	Aldehyde Reductase (Aldose Reductase)
9.	Choline (Choline Chloride)
10.	Glutamine (L-Glutamine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Lenses
3.	Chemoprevention
4.	Intraperitoneal Injections
5.	Transplants (Transplant)