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Inosine Monophosphate (IMP)

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Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.

Also Known As:

IMP; Inosinic Acid; Inosinic Acids; Sodium Inosinate; Acid, Inosinic; Acids, Inosinic; Inosinate, Sodium; Monophosphate, Inosine; Monophosphate, Ribosylhypoxanthine; Ribosylhypoxanthine Monophosphate; 5'-Inosinic acid

Networked: 805 relevant articles (30 outcomes, 102 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schultz, Harold D: 5 articles (02/2010 - 08/2005)
2.	Li, Yu-Long: 5 articles (02/2010 - 08/2005)
3.	Lavine, Steven J: 5 articles (06/2006 - 11/2003)
4.	Kuntz, Charles: 4 articles (02/2015 - 09/2011)
5.	Pettigrew, David B: 4 articles (02/2015 - 09/2011)
6.	Ishii, Kazunari: 4 articles (12/2013 - 07/2004)
7.	Arevalo, J Fernando: 4 articles (10/2012 - 09/2005)
8.	Hargens, Alan R: 4 articles (07/2012 - 04/2004)
9.	Jans, David A: 4 articles (12/2011 - 01/2006)
10.	Sullivan, Lori S: 4 articles (01/2007 - 03/2002)

Related Diseases

1.	Ischemia 02/01/2002 - "The response of 38 mechanically insensitive afferents to ischemia [2.83 +/- 0.14 (SD) imp/s] was significantly greater than that of 17 mechanically sensitive afferents (from 0.41 +/- 0.05 to 0.74 +/- 0.15 imp/s). " 12/01/2011 - "In particular, the stronger correlation coefficient between the ASL-value and ACZ-IMP-value might suggest that perfusion imaging by ASL-MRI could show the potentially dangerous zone for ischemia." 02/01/2001 - "(4) During 10 min renal ischemia, the averaged multi-unit discharge rate of the renal afferent was increased from 0.14 +/- 0.08 to 0.65 +/- 0.12 imp/s (P < 0.01). " 07/01/1996 - "Furthermore, the activity of ischemically sensitive afferents gradually increased throughout ischemia with peak activity (0.68 +/- 0.14 imp/s) occurring at 600 +/- 39 s, although tissue PO2 remained constant. " 01/01/1993 - "The increase of IMP in the rat heart after ischemia was several-fold higher. "
2.	Pain (Aches) 01/01/2009 - "IMP frequently result in a significant reduction in quality of life in affected individuals, mainly because of troublesome symptoms such as intractable itch and pain. " 11/01/2013 - "In this case series, BoNT-A reduced the IMP and eliminated exertional pain in anterior or anterolateral CECS of the leg for up to 9 months after the intervention. " 11/01/2014 - "The amplitude of the pulse-synchronous IMP oscillations at rest after an exercise test that elicits a patient's leg pain and muscle fatigue has high sensitivity to identify an abnormally elevated IMP. " 01/01/2014 - "In the published literature, it is unclear whether these children develop idiopathic musculoskeletal pain (IMP) such as complex regional pain syndrome (CRPS). " 11/01/2009 - "These observations cannot sufficiently be explained by the CFCS model and suggest that factors other than IMP have an additional effect on pain generation during exercise in elite rowers."
3.	Neoplasms (Cancer) 02/01/1996 - "This indicates faster clearance of IMP from the tumor tissue than that from the normal brain tissue. " 01/01/2015 - "This cell population, referred to as intermediate mesodermal progenitor (IMP) cells, is capable of unlimited expansion, lacks tumor formation potential, and, upon appropriate stimulation, readily acquires properties of a sub-population of kidney cells. " 01/01/2015 - "A subgroup of patients that qualifies for surgery will be treated preoperatively with the IMP to verify homing of the MSCs to tumors as to be confirmed in the surgical specimen. " 09/01/2014 - "The CAS/imp-α1 transport cycle is linked to XIAP and is required to maintain tumor cell survival in HCC. " 09/01/2014 - "Disruption of the CAS/imp-α1 transport cycle by RNAi in HCC cell lines resulted in decreased tumor cell growth and increased apoptosis. "
4.	Infection 09/01/2015 - "A total of 120 carbapenem resistant E.coli (n=32) and K.pneumoniae (n=88) from blood stream infections were screened for the presence of carbapenem resistant genes KPC, NDM, IMP, VIM, and OXA-48 like using both conventional multiplex PCR and Xpert(®) Carba-R test. " 07/01/2014 - "The role of ITK in this process suggests a mechanism by which IMP CD8(+) T cells can be generated rapidly in response to infection. " 06/01/2014 - "To investigate control of an outbreak due to orthopedic infections caused by Enterobacteriaceae producing IMP carbapenemases. " 10/01/2013 - "Three cases of IMP-type metallo-β-lactamase-producing Enterobacter cloacae bloodstream infection in Japan." 01/01/2013 - "Replacing either IMP E2 amino acid 181 or 214 with the corresponding McM amino acid lowered mosquito infection rates to McM-like levels. "
5.	Pulmonary Tuberculosis 04/01/1992 - "Uptake and clearance of IMP was considered to be affected by the active phase of pulmonary tuberculosis." 04/01/1992 - "Lung scintigraphy using N-isopropyl-p-[123I]iodoamphetamine (IMP) was performed on 26 patients with pulmonary tuberculosis. " 04/01/1992 - "Lung scintigraphy with [123I]IMP in patients with pulmonary tuberculosis." 10/01/1999 - "Human T-cell proliferation assays in donors comprising tuberculoid leprosy and pulmonary tuberculosis patients and healthy BCG vaccinees showed significantly greater potency of IMP over PMP and this immunodominance appeared to be directed towards CD4+ cells. "

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Oxidoreductases
3.	Adenosine Monophosphate (AMP)
4.	Adenosine Diphosphate (ADP)
5.	bredinin (mizoribine)
6.	Hypoxanthine
7.	Inosine
8.	Adenosine
9.	Xanthine
10.	IMP Dehydrogenase

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
4.	Intravenous Injections
5.	Transplantation (Transplant Recipients)