Inosine

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)

Networked: 596 relevant articles (22 outcomes, 57 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Benowitz, Larry I: 6 articles (01/2015 - 06/2002)
2.	Szabó, Csaba: 5 articles (02/2013 - 04/2002)
3.	Haskó, G: 5 articles (01/2003 - 01/2000)
4.	Yazdanparast, Razieh: 4 articles (03/2009 - 11/2005)
5.	Floryk, Daniel: 4 articles (11/2008 - 12/2004)
6.	Marton, A: 4 articles (01/2003 - 04/2001)
7.	Szabó, C: 4 articles (12/2001 - 01/2000)
8.	Juhász, G: 3 articles (08/2015 - 08/2004)
9.	Hedstrom, Lizbeth: 3 articles (05/2015 - 08/2005)
10.	Hooper, D Craig: 3 articles (02/2014 - 12/2002)

Related Diseases

1.	Anoxia (Hypoxia) 11/01/2011 - "The protective effects of inosine against chemical hypoxia on cultured rat oligodendrocytes." 06/01/2015 - "The administration of exogenous cIMP or inosine 5'-triphosphate causes augmented vasoconstriction to hypoxia. " 12/01/2011 - "In contrast, inosine peaked at over 10 μM in interstitial fluid during hypoxia and also during reperfusion, while effluent levels remained relatively unchanged at lower levels. " 11/01/2011 - "In addition, immature OLs were more susceptible to hypoxia than mature OLs; and at the similar degree of injury, inosine protected immature and mature OLs differently. " 11/01/2011 - "However, whether oligodendrocytes (OLs) could also be protected from hypoxia by inosine is not known. "
2.	Ischemia 02/01/2013 - "The present study supports the view that testing of inosine for protection against various forms of warm and cold liver ischemia is relevant." 10/01/1979 - "[Experimental study: inosine and renal ischemia]." 11/01/2002 - "We conclude that inosine has a beneficial effect in modulating both gut barrier dysfunction and distant organ injury in response to gut ischemia-reperfusion." 01/01/1993 - "Pretreatment with inosine almost removed the harmful effect of ischemia on bile flow. " 06/01/1990 - "We wished (a) to determine inosine's effect in isolated rat hearts and (b) to determine if inosine attenuates myocardial dysfunction after transient global ischemia. "
3.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2013 - "Thus, inosine might be a useful therapeutic for improving outcome after spinal cord injury. " 07/01/2006 - "Assessment of the potential protective effects of inosine on an animal model of spinal cord injury. " 01/01/2015 - "Inosine Improves Neurogenic Detrusor Overactivity following Spinal Cord Injury." 11/01/2014 - "We, herein, evaluated the effect of oral inosine treatment on spinal cord injury (SCI) recovery by means of locomotor and bladder function, quantification of neurons and spinal cord tissue sparing. " 01/01/2013 - "Inosine enhances axon sprouting and motor recovery after spinal cord injury."
4.	Reperfusion Injury 03/01/2009 - "Inosine has neuroprotective effects against cerebral and cardiac ischemia-reperfusion injury. " 03/01/2009 - "To investigate the effects of inosine on in vitro ischemia-reperfusion injury to urinary bladders in adult rats. " 11/01/2002 - "Inosine modulates gut barrier dysfunction and end organ damage in a model of ischemia-reperfusion injury." 08/01/2001 - "These findings demonstrate that pretreatment with inosine attenuates the local and systemic proinflammatory responses associated with skeletal muscle reperfusion injury." 01/01/2010 - "Effects of inosine on reperfusion injury after cardiopulmonary bypass."
5.	Brain Ischemia (Cerebral Ischemia) 03/01/2005 - "The purpose of this study was to examine the protective effects of inosine against cerebral ischemia. " 09/01/2005 - "The most important findings of this study suggest that inosine markedly inhibited platelet activation in vitro and in vivo, as well as cerebral ischemia. " 09/01/2005 - "In in vivo studies, inosine (400 mg/kg) significantly prolonged the latency period of inducing platelet plug formation in mesenteric venules of mice, and administration of 2 doses (100 mg/kg) or a single dose (150 mg/kg) of inosine significantly attenuated MCAO-induced focal cerebral ischemia in rats. " 09/01/2005 - "In the present study, we further investigated the inhibitory effects of inosine on platelet activation in vitro and in vivo, as well as in attenuating middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats. " 08/01/2006 - "This study examined the effects of inosine on neuronal apoptosis and CytC mRNA expression following hypoxic-ischemic brain damage (HIBD) in order to investigate the neuroprotectivity of inosine against cerebral ischemia injury in neonatal rats and the possible mechanism. "

Related Drugs and Biologics

1.	Adenosine
2.	Hypoxanthine
3.	Uric Acid (Urate)
4.	Xanthine
5.	Adenine
6.	Adenosine Monophosphate (AMP)
7.	Inosine Monophosphate (IMP)
8.	Pentylenetetrazole (Metrazol)
9.	Adenosine Triphosphate (ATP)
10.	Purines

Related Therapies and Procedures

1.	Radiotherapy
2.	Drug Therapy (Chemotherapy)
3.	Total Parenteral Nutrition
4.	Ligation
5.	Oral Administration