Inhibins (Inhibin)

Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively

Also Known As:

Networked: 798 relevant articles (20 outcomes, 131 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mylonas, Ioannis: 27 articles (10/2013 - 01/2005)
2.	Friese, Klaus: 14 articles (10/2013 - 01/2005)
3.	Shabani, Naim: 13 articles (10/2011 - 01/2005)
4.	Brüning, Ansgar: 12 articles (10/2012 - 05/2009)
5.	Matzuk, Martin M: 12 articles (10/2010 - 01/2003)
6.	Jeschke, Udo: 11 articles (09/2010 - 01/2005)
7.	Young, Robert H: 10 articles (10/2015 - 04/2002)
8.	Kuhn, Christina: 10 articles (07/2011 - 01/2005)
9.	Petraglia, Felice: 9 articles (09/2014 - 05/2002)
10.	Makovitzky, Josef: 9 articles (08/2011 - 06/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "Here we determined whether inhibin-α autoimmunity is effective in both prevention and treatment of ovarian tumors. " 11/01/1997 - "In diagnostically challenging cases, our data indicate that inhibin immunohistochemistry is a very useful adjunct because granulosa and sertoli-stromal tumors are positive whereas other potential mimickers have been negative thus far." 02/01/2004 - "The diagnosis of Sertoli cell tumors is sometimes difficult and can be improved using anti inhibin immunohistochemistry. " 09/01/2008 - "The results of this study show that although it is not complete specificity, inhibin, contrarily to the other markers, can be used to help in the distinction between ovarian sex cord-stromal neoplasms and the other primary and metastatic tumors." 06/01/2004 - "To investigate the potential diagnostic value of A103 and inhibin-alpha in adrenocortical tumors and to evaluate the applicability of tissue microarray/tissue chip in pathological studies using immunohistochemistry. "
2.	Granulosa Cell Tumor 11/01/1994 - "In 13 subjects who were clinically disease free with a previous diagnosis of granulosa cell tumor, serum inhibin concentrations remained within the normal range for reproductive status. " 05/01/2004 - "Inhibin stain may be helpful in identifying granulosa cell tumors in cell block specimens." 01/01/1997 - "Serum inhibin level evaluation should be incorporated into large-group trials of therapy for granulosa cell tumors." 11/01/1994 - "The aim of this study was to determine if elevations in serum inhibin predated clinical recurrence in patients with a diagnosis of granulosa cell tumor. " 09/01/2013 - "Our results showed that in a human granulosa cell tumor-derived cell line (KGN) and in human granulosa-lutein cells (hGL), FSH induced the expression of NUR77 and inhibin-alpha, although inhibin-alpha expression did not increased following FSH treatment if NUR77 was knocked down. "
3.	Ovarian Neoplasms (Ovarian Cancer) 06/01/2002 - "Clinical studies continue to uphold the use of inhibin as a marker for ovarian cancer, but have not generally supported its use over standard prognostic markers in assisted reproductive technologies. " 06/30/2001 - "The observation that inhibin levels are elevated in ovarian cancer has stimulated studies of their relevance to the molecular pathogenesis of these malignancies. " 03/01/1999 - "The aim of the study was to identify the forms of inhibin found in a range of ovarian cancers using a range of inhibin assays with varying specificities. " 11/01/1993 - "The aim of this study was to measure serum inhibin in a prospective, consecutive series of 200 patients admitted for suspected ovarian cancer. " 01/01/2008 - "[Role of total inhibin in diagnosis and monitoring of ovarian cancer in postmenopausal women]."
4.	Sex Cord-Gonadal Stromal Tumors (Sex Cord-Stromal Tumor) 09/01/2008 - "The purposes of this study is to examine inhibin and other markers immunoreactivity to ovarian sex cord-stromal tumors and their histological mimics and to discuss its value in the differential diagnosis. " 05/01/1998 - "Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody." 09/01/2012 - "Inhibin-α and protein gene product 9.5 were expressed in 8 and 10 sex cord-stromal tumors, respectively. " 07/01/2007 - "The solid type, nest type, cord type, palisade type, cystic type and spindle type, which were observed in sex-cord stromal tumors, showed a positive immunoreaction for S100 but little or no positive immunoreaction for inhibin alpha with an exception of positive result in the palisade type. " 01/01/2003 - "Inhibin immunohistochemical staining: a practical approach for the surgical pathologist in the diagnoses of ovarian sex cord-stromal tumors."
5.	Endometrioid Carcinoma 11/01/2011 - "Thus, the inhibin-betaB subunit appears not to be a useful prognostic marker regarding endometrioid adenocarcinomas. " 11/01/2011 - "A series of 227 uterine endometrioid adenocarcinomas of a previous well-characterized cohort were re-evaluated for the expression of the inhibin-betaB subunit and correlated with several clinicopathological characteristics and the clinical outcome. " 11/01/2011 - "However, the prognostic significance and clinical implications of the inhibin-betaB subunit in uterine endometrioid adenocarcinomas is still not defined yet. " 08/01/2011 - "A series of 229 uterine endometrioid adenocarcinomas from a previously well-characterized cohort were re-evaluated for expression of the inhibin-βA subunit and correlated with several clinicopathological characteristics and clinical outcomes. " 08/01/2011 - "However, the prognostic significance and clinical implications of inhibin-βA subunits in uterine endometrioid adenocarcinomas have not been defined. "

Related Drugs and Biologics

1.	Inhibins (Inhibin)
2.	calretinin
3.	inhibin A
4.	Hormones
5.	Follistatin
6.	Paraffin
7.	Keratins (Keratin)
8.	inhibin B
9.	Formaldehyde (Formol)
10.	Activins (Activin)

Related Therapies and Procedures

1.	Kidney Transplantation
2.	Aftercare (After-Treatment)
3.	Transplantation (Transplant Recipients)
4.	Drug Therapy (Chemotherapy)
5.	Orchiectomy (Orchidectomy)