Inhibins (Inhibin)

Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively

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Networked: 1049 relevant articles (24 outcomes, 152 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mylonas, Ioannis: 27 articles (10/2013 - 01/2005)
2.	Friese, Klaus: 15 articles (10/2013 - 01/2005)
3.	Shabani, Naim: 14 articles (10/2011 - 01/2005)
4.	Young, Robert H: 13 articles (01/2021 - 04/2002)
5.	Matzuk, Martin M: 13 articles (10/2010 - 01/2003)
6.	Jeschke, Udo: 12 articles (09/2010 - 01/2005)
7.	Brüning, Ansgar: 11 articles (10/2012 - 05/2009)
8.	Kuhn, Christina: 11 articles (07/2011 - 01/2005)
9.	Oliva, Esther: 9 articles (01/2021 - 04/2002)
10.	Petraglia, Felice: 9 articles (09/2014 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "Here we determined whether inhibin-α autoimmunity is effective in both prevention and treatment of ovarian tumors. " 11/01/1997 - "In diagnostically challenging cases, our data indicate that inhibin immunohistochemistry is a very useful adjunct because granulosa and sertoli-stromal tumors are positive whereas other potential mimickers have been negative thus far." 02/01/2004 - "The diagnosis of Sertoli cell tumors is sometimes difficult and can be improved using anti inhibin immunohistochemistry. " 10/07/2022 - "Inhibin Alpha Expression in Human Tumors: A Tissue Microarray Study on 12,212 Tumors." 03/01/2021 - "Additional studies are necessary to determine the cause of inhibin staining, driving molecular alterations, natural history of this rare tumor, and to come up with consensus nomenclature."
2.	Granulosa Cell Tumor 11/01/1994 - "In 13 subjects who were clinically disease free with a previous diagnosis of granulosa cell tumor, serum inhibin concentrations remained within the normal range for reproductive status. " 11/01/1994 - "The aim of this study was to determine if elevations in serum inhibin predated clinical recurrence in patients with a diagnosis of granulosa cell tumor. " 11/01/2016 - "Abnormal inhibin secretion is generally observed in granulosa cell tumors. " 09/01/2013 - "Our results showed that in a human granulosa cell tumor-derived cell line (KGN) and in human granulosa-lutein cells (hGL), FSH induced the expression of NUR77 and inhibin-alpha, although inhibin-alpha expression did not increased following FSH treatment if NUR77 was knocked down. " 12/01/2009 - "Two case reports of women with recurrent granulosa cell tumors identified initially by increasing levels of inhibin. "
3.	Ovarian Neoplasms (Ovarian Cancer) 06/01/2002 - "Clinical studies continue to uphold the use of inhibin as a marker for ovarian cancer, but have not generally supported its use over standard prognostic markers in assisted reproductive technologies. " 03/01/1999 - "The aim of the study was to identify the forms of inhibin found in a range of ovarian cancers using a range of inhibin assays with varying specificities. " 11/01/1993 - "The aim of this study was to measure serum inhibin in a prospective, consecutive series of 200 patients admitted for suspected ovarian cancer. " 01/01/2008 - "[Role of total inhibin in diagnosis and monitoring of ovarian cancer in postmenopausal women]." 04/28/2007 - "Inhibin as a diagnostic marker for ovarian cancer."
4.	Ovarian Epithelial Carcinoma 07/01/2007 - "The aim of the present study was to evaluate whether the serum concentration of total inhibin has the sensitivity/specificity characteristics to become a diagnostic test for epithelial ovarian cancer in postmenopausal women. " 07/01/2007 - "The present data show that total inhibin is a sensitive and specific marker of epithelial ovarian cancers in postmenopausal women. " 05/01/1995 - "A more detailed analysis of the levels of inhibin, and its subunits in epithelial ovarian cancer is needed to identify the molecular forms of the immunoreactive material before optimised assays can be applied to this more common tumour." 11/01/1993 - "By contrast, elevated serum inhibin values were found in only nine of 65 women with non-mucinous epithelial ovarian cancers. " 07/01/2007 - "When total inhibin was combined with CA-125, all cases of serous and mucinous tumors were detected, and the overall sensitivity for epithelial ovarian cancers was 99% at 95% specificity. "
5.	Sex Cord-Gonadal Stromal Tumors (Sex Cord-Stromal Tumor) 09/01/2008 - "The purposes of this study is to examine inhibin and other markers immunoreactivity to ovarian sex cord-stromal tumors and their histological mimics and to discuss its value in the differential diagnosis. " 05/01/1998 - "Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody." 06/03/2020 - "Inhibin-α, CD99, and CD56 markers of sex cord-stromal tumors were detected on immunohistological examination; all pathology suggested a GCT. " 10/01/2018 - "A revised diagnosis of mixed sex cord stromal tumor with heterologous elements was favored because of the inhibin immunoreactivity. " 07/01/2007 - "The solid type, nest type, cord type, palisade type, cystic type and spindle type, which were observed in sex-cord stromal tumors, showed a positive immunoreaction for S100 but little or no positive immunoreaction for inhibin alpha with an exception of positive result in the palisade type. "

Related Drugs and Biologics

1.	Inhibins (Inhibin)
2.	Calbindin 2
3.	inhibin A
4.	Follistatin
5.	Proteins (Proteins, Gene)
6.	Hormones (Hormone)
7.	Monoclonal Antibodies
8.	Keratins (Keratin)
9.	Biomarkers (Surrogate Marker)
10.	Steroids

Related Therapies and Procedures

1.	Castration
2.	Kidney Transplantation
3.	Aftercare (After-Treatment)
4.	Therapeutics
5.	Drug Therapy (Chemotherapy)