Female Infertility

Diminished or absent ability of a female to achieve conception.

Also Known As:

Infertility, Female; Sterility, Postpartum; Sub-Fertility, Female; Subfertility, Female; Female Sterility; Female Sub-Fertility; Female Subfertility; Postpartum Sterility; Sub Fertility, Female; Sterility, Female

Networked: 977 relevant articles (18 outcomes, 109 trials/studies)

Relationship Network

Disease Context: Research Results

Urogenital Diseases: 126
- Genital Diseases: 114
  - Infertility: 19837
    - Female Infertility: 977
  - Female Genital Diseases: 393
    - Female Infertility: 977
- Female Urogenital Diseases and Pregnancy Complications
  - Female Urogenital Diseases
    - Female Genital Diseases: 393
      - Female Infertility: 977

Related Diseases

1.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
2.	Male Infertility (Male Sterility)
3.	Inflammation (Inflammations)
4.	Anovulation
5.	Leiomyoma (Uterine Fibroids)

Experts

1.	Lydon, John P: 8 articles (01/2021 - 01/2002)
2.	Salumets, Andres: 7 articles (01/2012 - 03/2007)
3.	DeMayo, Francesco J: 6 articles (01/2021 - 06/2002)
4.	Altmäe, Signe: 6 articles (12/2013 - 08/2007)
5.	Stavreus-Evers, Anneli: 6 articles (12/2013 - 08/2007)
6.	Agarwal, Ashok: 5 articles (01/2019 - 06/2005)
7.	Yousefi, Mehdi: 4 articles (06/2022 - 10/2020)
8.	He, Lin: 4 articles (02/2022 - 01/2019)
9.	Du, Xing: 4 articles (10/2021 - 11/2016)
10.	Li, Qifa: 4 articles (10/2021 - 11/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Female Infertility:

1.	AntioxidantsIBA 12/17/2021 - "Even though the use of antioxidants, even under conditions of auto-medication, was shown to improve many functions related to female infertility related to oxidative stress, the lack of medical control and supervision can lead to an overmedication resulting in an opposite extreme, reductive stress, which can be counterproductive with regard to reproductive function and produce various adverse health effects in general. " 11/16/2023 - "The aim of this study was to examine the link between female infertility and dietary antioxidant index (DAI). " 12/17/2021 - "Towards Personalized Antioxidant Use in Female Infertility: Need for More Molecular and Clinical Studies." 01/01/2021 - "Therefore, larger well-designed, dose-response studies in humans are further warranted to incorporate natural antioxidant compounds into the clinical management of female infertility." 11/16/2023 - "Female infertility and dietary antioxidant index (DAI); a case-control study."
2.	Proteins (Proteins, Gene)FDA Link 05/01/2022 - "In this study, excluding the factors of severe female infertility, a total of 281 sperm samples were collected to compare the ACTL7A expression levels of sperms with high and low effective embryo rates and analyze the correlation between protein levels and in-vitro fertilization (IVF) laboratory outcomes. " 02/01/2006 - "From these studies we conclude that the DCV proteins, IA-2 and IA-2beta, play an important role in LH secretion and that alterations in structural proteins of DCV can result in female infertility." 02/01/2022 - "Disruption of egg-specific protein causes female sterility in Bombyx mori." 01/01/2022 - "Both proteins are expressed in the developing ovary from pupae to the adult stage and display enriched expression in terminal filament and stalk cells, while their genetic removal from early germaria results in severe disruption of the subsequent oogenesis, leading to female sterility. " 11/01/2021 - "Pitfalls in establishing mouse model of female infertility by immunization with human centromere protein."
3.	Follicle Stimulating Hormone (Follitropin)FDA Link 05/30/2023 - "Recombinant follicle-stimulating hormone (FSH) is commonly used for the treatment of female infertility and is increasingly being used in males as well, as recommended by notable guidelines. " 10/01/2022 - "Premature ovarian insufficiency (POI) is a leading form of female infertility, characterised by menstrual disturbance and elevated follicle-stimulating hormone before age 40. " 07/01/2005 - "Use of follicle-stimulating hormone for the treatment of female infertility - current concepts." 04/25/2023 - "Follicle stimulating hormone (FSH) is widely used for the treatment of female infertility, where the level of FSH is suboptimal due to which arrest in follicular development and anovulation takes place. " 04/20/2020 - "Premature ovarian insufficiency (POI) is a severe disorder of female infertility, characterized by 4-6 months of amenorrhea before the age of 40 years, with elevated follicle stimulating hormone (FSH) levels (> 25 IU/L). "
4.	LipidsIBA 01/01/2020 - "In the current study, we aimed to test the hypothesis that unexplained female infertility is related to lipid metabolism, given the lipid signature of positive-outcome IVF patients we previously found. " 07/13/2023 - "Furthermore, the association between lipid-related traits and female infertility risk merits more studies." 07/13/2023 - "Although observational studies have demonstrated that blood lipids are associated with female infertility, the causality of this association remains unclear. " 07/13/2023 - "Subsequently, MR analysis was performed using inverse variance-weighted (IVW), weighted median, weighted-mode, simple-mode and MR-Egger regression to demonstrate the causal relationship between lipids and female infertility. " 07/13/2023 - "We performed a univariable and multivariable Mendelian randomization (MR) analysis to evaluate the causal relationship between blood lipids and female infertility. "
5.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/01/2023 - "A deeper understanding of the reproductive neuroendocrine network governing hypothalamic gonadotropin-releasing hormone release can offer novel therapeutic targets for the treatment of female subfertility, leading to improved clinical outcomes, less invasive routes of administration, and decreased treatment-related side-effects. " 08/01/2017 - "Despite being a treatable form of female infertility, the presumable availability of treatment does not necessarily ensure adequate quality of life for women with isolated GnRH deficiency." 07/01/1993 - "[Use of GnRh analogues in the treatment of female sterility]." 01/01/1987 - "[Successful treatment of female infertility of hypothalamic origin using pulsed administration of gonadotropin-releasing hormone (LHRH)]." 01/01/1987 - "This work shows that hypothalamic female sterility is the proper indication for treatment using LH/RH. "
6.	Glucose (Dextrose)FDA LinkGeneric 07/01/1969 - "[Anomalous glucose metabolism and female sterility]." 01/01/2022 - "Given humanin's new frontier for the design of novel therapeutic approaches for male infertility, male contraception, female infertility, and glucose metabolism in polycystic ovary syndrome, it is worthy of further study on its protective effects and clinical applications in reproductive function."
7.	humaninIBA 01/01/2022 - "Given humanin's new frontier for the design of novel therapeutic approaches for male infertility, male contraception, female infertility, and glucose metabolism in polycystic ovary syndrome, it is worthy of further study on its protective effects and clinical applications in reproductive function."
8.	Clomiphene (Clomifene)FDA LinkGeneric 01/01/2018 - "Clomiphene citrate is a drug that stimulates ovulation and is commonly used in cases of female infertility. " 03/01/2012 - "Clomiphene citrate is the most used drug for the treatment of female infertility, a common condition in western societies and developing countries. " 06/01/2011 - "It is concluded that ovarian drilling is an option in the management of female infertility associated with PCOS, especially as a second-line treatment after the failure of clomiphene citrate treatment." 11/01/1977 - "[Use of clomiphene citrate in several cases of female sterility]." 01/01/2021 - "Clomiphene citrate is first line therapy of female infertility but is also frequently abused by athletes. "
9.	ProlactinIBA 06/01/2003 - "Measurements of TSH and prolactin are generally included in the evaluation of female infertility, but their value in women coming to in vitro fertilization (IVF) has been questioned. " 03/01/1994 - "The prolactin-like effect of hGH in these mice probably induced female sterility, and milk could therefore not be obtained. " 01/31/1986 - "[Prolactin and female sterility]." 12/09/1978 - "Serum-prolactin in female infertility." 11/04/1978 - "Prolactin suppression in the treatment of female infertility."
10.	Bromocriptine (Parlodel)FDA LinkGeneric 01/01/1986 - "The safety of bromocriptine in hyperprolactinaemic female infertility: a literature review." 07/01/1983 - "[Anovular female sterility treated with bromocriptine CB 154 (Parlodel)]." 12/20/1975 - "Bromocriptine treatment of female infertility: report of 13 pregnancies." 06/01/1983 - "Short-term bromocriptine therapy in female infertility." 01/01/1992 - "[Experiences with bromocriptine treatment of female infertility due to hyperprolactinemia]."

Therapies and Procedures

1.	Therapeutics 07/01/2019 - "In the incomplete outcome data, all studies were low risk, except 1. Acupuncture and its combined therapy may be effective for treating female infertility. " 11/19/2020 - "We performed a systematic literature search of PubMed, Cochrane Library, Embase, and Ovid databases through April 2019 for Randomized Controlled Trials (RCTs) evaluating the effectiveness and safety of NAC as adjuvant therapy in female infertility. " 02/01/2015 - "We searched the Medline and Cochrane databases until December 2013 for randomized controlled trials and meta-analyses investigating Chinese herbal medicine therapy for female infertility and compared clinical pregnancy rates achieved with CHM versus WM drug treatment. " 01/30/2024 - "Herbal therapeutics for female infertility: A systematic review and meta-analysis." 11/15/2023 - "To address this challenge, mesenchymal stem cell therapy has been proposed as a potential treatment for female infertility and/or restoration of ovarian function in POR women. "
2.	Physical Therapy Modalities (Physical Therapy Technique) 05/01/2015 - "Ten-year Retrospective Study on the Efficacy of a Manual Physical Therapy to Treat Female Infertility." 02/17/2015 - "Ten-year Retrospective Study on the Efficacy of a Manual Physical Therapy to Treat Female Infertility." 06/18/2004 - "Treating female infertility and improving IVF pregnancy rates with a manual physical therapy technique."
3.	Contraception (Birth Control) 01/01/2010 - "Some of these genes may provide novel targets for developing better methods for contraception and specific diagnosis and treatment of female infertility." 06/28/2006 - "The risk of female infertility related to tobacco is now well-proven, as is the risk of arterial and venous thrombotic event when tobacco is associated with oral contraception. " 12/01/1986 - "They may have relevance to studies of female infertility, birth control, and toxemia of pregnancy. " 01/01/2017 - "Female infertility is when a woman of reproductive age and sexual active, without contraception, cannot get pregnant after a year and more or keeps having miscarriages. " 07/01/1984 - " Soviet research concentrates on 3 major areas: diagnosis and treatment of female sterility, endocrinological aspects of contraception, and birth control prostaglandins."
4.	Moxibustion 11/01/2019 - "This review will provide evidence to judge for judging whether moxibustion is effective in treating female infertility patients undergoing IVF-ET. " 11/01/2019 - "This study will provide a high-quality comprehensive evaluation of the efficacy and safety of moxibustion in the treatment of female infertility patients undergoing IVF-ET. " 11/01/2019 - "The clinical randomized controlled trials or quasi-randomized controlled trials related to moxibustion in female infertility patients undergoing IVF-ET will be included in the study. " 01/01/2021 - "To clarify CAM effectiveness, safety, and mechanism, this paper systematically reviewed the literature about its treatment of female infertility collected from PubMed and CNKI databases and mainly introduced acupuncture, moxibustion, and oral Chinese herbal medicine. " 11/01/2019 - "Efficacy and safety of moxibustion in female infertility patients undergoing in vitro fertilization and embryo transfer: A systematic review protocol."
5.	Drug Therapy (Chemotherapy) 01/01/2023 - "Current pharmacotherapy and future directions for neuroendocrine causes of female infertility." 05/22/2020 - "Different bioengineering strategies can be presently adopted and have been shown to have great potential in the treatment of female infertility and ovarian dysfunction deriving from chemotherapy, congenital malformations, massive adhesions as well as aging and lifestyle. " 10/01/2019 - "State of the art and emerging drug therapies for female infertility." 02/01/2015 - "Our review suggests that management of female infertility with Chinese herbal medicine can improve pregnancy rates 2-fold within a 3-6 month period compared with Western medical fertility drug therapy. " 12/01/2011 - "Our review suggests that management of female infertility with Chinese Herbal Medicine can improve pregnancy rates 2-fold within a 4 month period compared with Western Medical fertility drug therapy or IVF. "