Indoramin

06/01/1986 - "Therapeutic trials have shown indoramin to be effective in lowering blood pressure in all grades of hypertension: mild and moderate hypertension when used alone, but generally in combination with a thiazide diuretic, and in moderate to moderately severe hypertension when used in combination with a beta-blocker and diuretic. "
10/20/1990 - "A placebo-controlled trial was used to assess the antihypertensive efficacy of indoramin in the management of pregnancy hypertension. "
01/01/1983 - "An open study was carried out to assess the efficacy of indoramin used as second step therapy in 30 patients with moderate to severe hypertension who had failed to respond adequately to monotherapy with a thiazide or beta-blocker. "
12/25/1982 - "Indoramin in the first-line treatment of hypertension."
04/01/1990 - "4. It is concluded that in treating hypertension associated with pregnancy, this study does not provide evidence to depart from the usual clinical practice of titrating indoramin dosage with control of blood pressure as the end-point, keeping in mind the restriction of the dose-limiting side-effect of sedation."

01/01/1987 - "The first dose of the alpha 1 blocker indoramin elicits a significant reduction in ventricular preload and afterload and augmentation of ventricular performance in patients with congestive heart failure."
02/01/1987 - "Twenty-one patients with moderately severe congestive heart failure participated in a double-blind, randomized, parallel placebo-controlled trial designed to evaluate the effects of long-term (2 months) indoramin therapy on rest and exercise hemodynamics, exercise capacity and clinical status of patients with this clinical syndrome. "
02/01/1987 - "Long-term indoramin therapy in congestive heart failure: a double-blind, randomized, parallel placebo-controlled trial."
01/01/1987 - "Twenty patients with congestive heart failure underwent hemodynamic studies before and over 10 hours after the administration of 25, 50, and 75 mg of indoramin, an alpha 1-adrenergic antagonist. "
01/01/1986 - "Twenty-one patients with congestive heart failure (New York Heart Association functional class III) underwent a double-blind, parallel, placebo-controlled, randomized trial of indoramin (average dose of 50 mg every 12 h in 11 patients) versus placebo (n = 10). "

05/01/2001 - "The aim of this study was to determine the outcome of treatment with oral indoramin on patients with chronic anal fissure in the setting of a double-blind randomized placebo-controlled trial. "
05/01/2001 - "A double-blind randomized placebo-controlled trial of oral indoramin to treat chronic anal fissure."
05/01/2001 - "After 3 months, the chronic anal fissure in the indoramin group had recurred. "
05/01/2001 - "Twenty-three patients with chronic anal fissure were computer randomized to receive a 6-week course of oral indoramin (20 mg) or placebo in identical capsules, twice daily and with bulk-forming laxatives. "
06/01/2000 - "Indoramin reduced anal resting pressures in those with anal fissure by a mean of 35.8 percent, from 106.9 +/- 22.15 cm H2O to 68.6 +/- 20.35 cm H2O, and in those without anal fissure by a mean of 39.9 percent, from 84.17 +/- 27.46 cm H2O to 52.17 +/- 24.78 cm H2O, after one hour. "

10/01/1980 - "Is indoramin useful in the treatment of bronchial asthma?"
01/01/1978 - "Long-term trial of an alpha adrenoceptor blocking drug (Indoramin) in asthma. "
01/01/1978 - "Eight patients suffering from both asthma and migraine underwent a clinical trial for 3 months of indoramin, an alpha adrenoceptor antagonist with antihistamine and antiserotonin activity. "
06/14/1975 - "Letter: practolol, indoramin, and asthma."

05/01/2010 - "Visante OCT and ocular echography follow-up examinations were normal, and Indoramin was prescribed for migraine prophylaxis with no relapse after 10 months. "
01/01/1978 - "Patients were told indoramin was prescribed for migraine prophylaxis. "
01/01/1978 - "Eight patients suffering from both asthma and migraine underwent a clinical trial for 3 months of indoramin, an alpha adrenoceptor antagonist with antihistamine and antiserotonin activity. "
01/01/1984 - "The findings suggest that specific 5-HT receptors may be present in the human temporal artery and that alpha-adrenoceptor antagonism may be the pharmacological property of most relevance to the efficacy of indoramin in migraine prophylaxis."
06/01/1988 - "[Comparative study of indoramin versus dihydroergotamine in the preventive treatment of migraine]."