Indoprofen (Dexindoprofen)

A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)

Also Known As:

Networked: 81 relevant articles (13 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bi, Xiaowen: 1 article (12/2021)
2.	Jiang, Baolin: 1 article (12/2021)
3.	Liang, Juanjuan: 1 article (12/2021)
4.	Liu, Jie: 1 article (12/2021)
5.	Lu, Shuai: 1 article (12/2021)
6.	Luo, Lan: 1 article (12/2021)
7.	Yan, Xintong: 1 article (12/2021)
8.	Yin, Zhimin: 1 article (12/2021)
9.	Zhou, Jinyi: 1 article (12/2021)
10.	Cho, Sung Chun: 1 article (01/2020)

Related Diseases

1.	Pain (Aches) 01/01/1981 - "Both active drugs were significantly better than placebo on relief of pain, Ritchie index, and number of active, painful and swollen joints, morning stiffness; only indoprofen significantly improved grip strength. " 01/01/1981 - "A significant improvement was obtained with indoprofen in the different parameters measuring pain, from the first treatment period; results were similar at the end of the second period. " 01/01/1986 - "The pain and preference assessments were significantly in favor of indoprofen. " 01/01/1985 - "At 2-5 min after injection, pain reduction was greater with indoprofen, and more patients in this group had pain relief after 3-5 hours. " 01/01/1984 - "Intra-articular indoprofen was not superior to placebo as regards pain relief or increased joint mobility. "
2.	Osteoarthritis 01/01/1979 - "A multi-centre trial was carried out in 1629 patients with osteoarthrosis in 233 clinical centres to investigate the therapeutic efficacy and tolerability of indoprofen in this clinical condition. " 01/01/1982 - "Safety data on indoprofen are presented, deriving from three sources: the first was a phase 4 multicentre clinical study based on 4042 patients suffering from osteoarthritis and treated with 400-800 mg daily by mouth for about 4 weeks; the second was a survey based on a heterogeneous series of 2722 subjects belonging to phase 1, 2 and 3 investigations, and treated with 200 to 1200 mg daily by the oral and/or parenteral route for from 1 to more than 180 days; the third was a safety laboratory study conducted in 472 patients, most of whom had participated in the first study, while the remainder were included in the second. " 01/01/1981 - "The results of this study have confirmed the usefulness of indoprofen in the treatment of osteoarthritis." 01/01/1979 - "Indoprofen, a new non-steroidal anti-inflammatory drug, in the treatment of osteoarthrosis: report on a multi-centre study in 1629 patients." 01/01/1982 - "The influence of i.v. administration of indoprofen on template bleeding time and other haemostatic parameters was investigated in ten elderly subjects with osteoarthritis. "
3.	Postoperative Pain 06/01/1983 - "Dose-response study with indoprofen i.v. as an analgesic in postoperative pain." 01/01/1978 - "A double-blind, controlled trial is described in which a total of forty hospital in-patients suffering from severe post-operative pain were randomly allocated to treatment with one of two non-steroidal anti-inflammatory drugs, namely, either indoprofen which has a short half-life (two-hours) or naproxen which has a long half-life (thirteen hours). " 11/01/1985 - "The relative potency of intravenous indoprofen and intramuscular pentazocine in postoperative pain was evaluated. " 07/01/1980 - "The results demonstrate the analgesic efficacy of indoprofen in patients with severe postoperative pain, a dose-dependent effect, and a 13-to-16 potency ratio to ASA as judged from total pain relief." 11/01/1985 - "A study of the analgesic potency of indoprofen and pentazocine in postoperative pain."
4.	Headache (Headaches) 05/01/1985 - "Flunarizine was found effective in over 65% of the patients, while indoprofen was able to improve headache severity in only 30% of the subjects. " 05/01/1985 - "Forty-two migraineurs with interval headache (MIH) were treated with flunarizine in a 6-month open trial, while indoprofen was administered to 23 patients with MIH and 7 with chronic tension headache (CTH) in a 2-month, double-blind, cross-over placebo-controlled study. " 01/01/1982 - "One patient taking indomethacin developed headache and dizziness, requiring discontinuation of treatment; three patients on indoprofen complained of mild or moderate gastric pain."
5.	Cancer Pain 03/01/1975 - "Indoprofen, a new analgesic and anti-inflammatory drug in cancer pain." 03/01/1975 - "In a group of only 24 patients, the data supported the following conclusions: indoprofen at 100 and 200 mg single doses is effective in relieving cancer pain; it displays a dose-related analgesic effect comparable to that of aspirin with only one-tenth the dose." 03/01/1975 - "Evaluation of the analgesic activity of indoprofen was carried out in patients with cancer pain under double-blind conditions and compared with aspirin and placebo. " 09/01/1983 - "Effect of i.v. indoprofen on cancer pain and serum prolactin and growth hormone levels--a controlled pharmacologic study vs i. m. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Aspirin (Acetylsalicylic Acid)
3.	Ibuprofen (Motrin)
4.	Tablets
5.	Flunarizine
6.	Morphine (MS Contin)
7.	Narcotics (Narcotic Analgesics)
8.	aloxiprin
9.	Indomethacin (Indometacin)
10.	Naproxen (Naprosyn)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Episiotomy
3.	Oral Surgery (Maxillofacial Surgery)
4.	Punctures
5.	Cesarean Section (Caesarean Section)