Indapamide

A benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure is different enough (lacking the thiazo-ring) so it is not clear that the mechanism is comparable.

Also Known As:

Networked: 504 relevant articles (83 outcomes, 154 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Chalmers, John: 18 articles (01/2015 - 05/2003)
2.	Woodward, Mark: 13 articles (01/2015 - 05/2003)
3.	MacMahon, Stephen: 9 articles (01/2015 - 05/2003)
4.	Patel, Anushka: 8 articles (10/2014 - 01/2007)
5.	Peters, Ruth: 8 articles (03/2013 - 01/2006)
6.	Poulter, Neil: 6 articles (01/2015 - 05/2009)
7.	Safar, Michel E: 6 articles (01/2015 - 08/2002)
8.	Arima, Hisatomi: 6 articles (10/2014 - 06/2006)
9.	Neal, Bruce: 6 articles (10/2014 - 05/2003)
10.	Beckett, Nigel: 6 articles (03/2013 - 01/2006)

Related Diseases

1.	Hypertension (High Blood Pressure) 03/01/2003 - "This study will complete the knowledge of the efficacy of indapamide SR in hypertension and target organ damage and will provide valuable information on the management of type 2 diabetic hypertensives with microalbuminuria." 01/01/1994 - "These results confirm the clinical efficacy of indapamide and its beneficial effects on quality of life in patients with mild and moderate hypertension when administered in monotherapy." 09/01/1984 - "Thus, indapamide appears to offer a suitable alternative to more established drugs as a 'first-line' treatment in patients with mild to moderate hypertension. " 09/28/2001 - "Indapamide is an oral diuretic antihypertensive drug effective for patients with mild or moderate essential hypertension. " 03/01/1983 - "Indapamide: clinical pharmacology, therapeutic efficacy in hypertension, and adverse effects."
2.	Stroke (Strokes) 06/01/2013 - "It is mainly the combination of an ACE inhibitor + indapamide that seems to be modern and promising, and it is, on the basis of large clinical trials, recommended also for diabetics (ADVANCE) or for secondary prevention following a cerebrovascular accident (PROGRESS) or for the elderly (HYVET). " 09/01/1995 - "The findings of this trial indicate that in patients with a history of stroke or TIA, blood pressure reduction of 5/2 mmHg with 2.5 mg indapamide reduced the first incidence of fatal and nonfatal stroke by 29%, with three-year absolute benefit of 29 events per 1000 participants." 11/01/2009 - "In conclusion, BP lowering by indapamide treatment reduced the recurrence of stroke and the incidence of cardiovascular events in Chinese patients with cerebrovascular disease. " 11/01/2009 - "In total, 143 patients on indapamide and 219 patients on placebo had recurrent strokes (hazard ratio for indapamide, 0.69; 95% confidence interval (CI): 0.54-0.89; P<0.001). " 07/01/2007 - "Indapamide is efficacious in prevention of further stroke, reduces effectively the blood pressure and the left ventricular mass index. "
3.	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 05/01/2004 - "Left ventricular hypertrophy in hypertensive patients in Indian primary care: prevalence and effect of treatment with sustained release indapamide." 10/01/2000 - "Effects of indapamide in rats with pressure overload left ventricular hypertrophy." 01/01/1993 - "Indapamide reduces hypertensive left ventricular hypertrophy: an international multicenter study." 12/01/1990 - "The effects of a diuretic, indapamide, on the regression of left ventricular hypertrophy were studied in a group of 9 patients with mild hypertension treated in an open therapeutic trial over a 12 month period. " 07/01/2012 - "Indapamide has protecting effects in a variety of conditions associated with high cardiovascular risk, such as diabetes, left ventricular hypertrophy, nephropathy and stroke. "
4.	Hypertrophy 01/01/1993 - "Morphometric analysis of myocyte cross-sectional areas evidenced that indapamide was the most effective in preventing myocyte hypertrophy (-33%, p < or = 0.0001). " 02/01/2001 - "Significant hypertrophy regression with indapamide sustained release 1.5 mg." 08/01/2009 - "It is concluded that the complex protective effects of the combined indapamide plus captopril treatment on hypertension may be exerted via its effects on blood pressure, hypertrophy and vasorelaxation." 08/01/1999 - "In experimental models of hypertension, perindopril/indapamide restored endothelial function, improved microvascular density, reduced left ventricular and aortic hypertrophy, and reversed renal end-organ damage. " 01/01/2011 - "The aim of this study was to analyze the effect of indapamide and its combination with ACE inhibitor (captopril) and antioxidant (Provinols™) on both myocardial hypertrophy and fibrosis. "
5.	Edema 01/01/1984 - "Indapamide, a new antihypertensive/diuretic agent, in the treatment of patients with edema." 07/01/1983 - "Clinical efficacy and safety of indapamide in the treatment of edema." 01/01/2013 - "Authors aimed to present a rare case of indapamide-induced transient myopia with ciliary body edema and supraciliary effusion. " 07/01/1983 - "Indapamide is a new antihypertensive diuretic agent indicated for the treatment of hypertension and edema. " 07/01/1983 - "This study concluded that indapamide in once-daily oral doses of 2.5, 5.0, or 10.0 mg was as safe and effective as a once-daily 100 mg dose of hydrochlorothiazide for the treatment of 219 patients with edema from various causes."

Related Drugs and Biologics

1.	Perindopril
2.	Hydrochlorothiazide (Esidrix)
3.	Enalapril
4.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
5.	Antihypertensive Agents (Antihypertensives)
6.	delapril
7.	Captopril (Capoten)
8.	Diuretics
9.	Amlodipine (Norvasc)
10.	Furosemide (Lasix)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Renal Dialysis (Hemodialysis)
4.	Oral Administration
5.	Protein-Restricted Diet (Diet, Protein Restricted)