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IMP Dehydrogenase

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An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.

Also Known As:

Inosine-5-Monophosphate Dehydrogenase; Acid Dehydrogenase, Inosinic; Dehydrogenase, IMP; Dehydrogenase, Inosine-5-Monophosphate; Dehydrogenase, Inosinic Acid; Inosine 5 Monophosphate Dehydrogenase; Inosinic Acid Dehydrogenase; IMP:NAD+ oxidoreductase

Networked: 115 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - Alcohol Oxidoreductases: 1
      - IMP Dehydrogenase: 115
        human IMPDH1 protein
        human IMPDH2 protein
        mouse IMPDH1
        mouse IMPDH2
        S cerevisiae IMD2 protein

Experts

1.	Hall, I H: 6 articles (07/2001 - 07/2000)
2.	Hedstrom, Lizbeth: 4 articles (01/2014 - 08/2005)
3.	Barnes, B J: 4 articles (07/2001 - 04/2001)
4.	Izydore, R A: 4 articles (07/2001 - 01/2001)
5.	Warren, A E: 3 articles (07/2001 - 01/2001)
6.	Wheaton, J R: 3 articles (07/2001 - 01/2001)
7.	Mizushina, Yoshiyuki: 2 articles (08/2013 - 01/2009)
8.	Takeuchi, Toshifumi: 2 articles (08/2013 - 01/2009)
9.	Yoshida, Hiromi: 2 articles (08/2013 - 01/2009)
10.	Sugawara, Fumio: 2 articles (08/2013 - 01/2009)

Related Diseases

1.	Infection 07/01/2015 - "When mice were immunized with an attenuated mutant strain into which IMP dehydrogenase had been inserted with a transposon, they were protected against V. vulnificus infection. " 12/01/2011 - "IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice." 08/01/2006 - "Our data do not support the use of ribavirin or other IMP dehydrogenase inhibitors for treating SARS infections in humans." 08/01/2006 - "Because of the conflicting data concerning the SARS-CoV inhibitory efficacy of ribavirin, an inosine monophosphate (IMP) dehydrogenase inhibitor, studies were done to evaluate the efficacy of ribavirin and other IMP dehydrogenase inhibitors (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR), mizoribine, and mycophenolic acid) in preventing viral replication in the lungs of BALB/c mice, a replication model for severe acute respiratory syndrome (SARS) infections (Subbarao, K., McAuliffe, J., Vogel, L., Fahle, G., Fischer, S., Tatti, K., Packard, M., Shieh, W.J., Zaki, S., Murphy, B., 2004. " 08/01/2014 - "We evaluated the potency of bafilomycin (BAF; inhibitor of vacuolar H+-ATPase (vATPase)), mycophenolic acid (MPA; inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH)), castanospermine (CAS; inhibitor of glucosidase), and deoxynojirimycin (DNJ; inhibitor of glucosidase) in blocking DENV infection of the mosquito midgut, using various treatment methods that included direct injection, ingestion by sugar feeding or blood feeding, and silencing of target genes by RNA interference (RNAi). "
2.	Severe Acute Respiratory Syndrome 08/01/2006 - "Because of the conflicting data concerning the SARS-CoV inhibitory efficacy of ribavirin, an inosine monophosphate (IMP) dehydrogenase inhibitor, studies were done to evaluate the efficacy of ribavirin and other IMP dehydrogenase inhibitors (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR), mizoribine, and mycophenolic acid) in preventing viral replication in the lungs of BALB/c mice, a replication model for severe acute respiratory syndrome (SARS) infections (Subbarao, K., McAuliffe, J., Vogel, L., Fahle, G., Fischer, S., Tatti, K., Packard, M., Shieh, W.J., Zaki, S., Murphy, B., 2004. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/1989 - "Kinetic properties of IMP dehydrogenase purified from rat hepatoma 3924A." 01/01/1989 - "3. Similarity of the kinetics of human leukemic cell IMP dehydrogenase to the rat hepatoma enzyme was documented. " 05/31/1988 - "Now we show that the binding to IMP dehydrogenase of these drugs at two separate sites is translated into synergistic inhibition of de novo guanylate biosynthesis and synergistic toxicity in rat hepatoma 3924A cells. " 03/22/1988 - "The hepatoma IMP dehydrogenase has a tetrameric structure with a subunit molecular weight of 60,000. " 01/01/1988 - "2. IMP dehydrogenase was purified 4,900-fold to homogeneity from rat hepatoma 3924A with a yield of 30%. "
4.	Neoplasms (Cancer) 07/01/2007 - "Recent development of IMP dehydrogenase inhibitors for the treatment of cancer." 07/01/2001 - "Implications of selective type II IMP dehydrogenase (IMPDH) inhibition by the 6-ethoxycarbonyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones on tumor cell death." 07/01/1999 - "Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis." 12/03/1993 - "The activity of IMP dehydrogenase (EC 1.2.1.14), the key enzyme of de novo guanylate biosynthesis, was shown to be increased in tumor cells. " 10/15/1992 - "To assess this role we examined IMP dehydrogenase expression in a series of human solid tumor tissues and tumor cell lines in comparison with their normal counterparts. "
5.	Leukemia 07/01/2001 - "It was shown previously that three 1,5-diazabicyclo[3.1.0]hexane-2,4-diones selectively inhibited human Type II IMP dehydrogenase (IMPDH) from Tmolt4 cell leukemia [Barnes et al., Biochemistry 2000;39:13641-50]. " 04/01/2001 - "The 1,2,4-triazolidine-3,5-diones, 1-(1-(3-methylphenyl)ethylidineamino)-4,4-diethyl-3,5-azetidinediones, and 4,4-disubstituted-3,5-pyrazolidinediones proved to be potent competitive inhibitors of human Tmolt4 leukemia Type II IMP dehydrogenase [IMPDH] activity, an enzyme isoform which is induced in highly proliferating cells. " 09/01/2011 - "Our previous studies have classified 3-Hydrogenkwadaphnin (3-HK), isolated from Dendrostellera lessertii (Thymelaeaceae), as a strong anti-proliferative agent that induces apoptosis among the treated leukemia cells mainly through IMP dehydrogenase inhibition. " 06/01/1992 - "Reciprocal alterations of GMP reductase and IMP dehydrogenase activities during differentiation in HL-60 leukemia cells." 01/01/1991 - "IMP dehydrogenase and GTP as targets in human leukemia treatment."

Related Drugs and Biologics

1.	tiazofurin
2.	Ribavirin (Virazole)
3.	Inosine Monophosphate (IMP)
4.	Guanosine Triphosphate (GTP)
5.	DNA (Deoxyribonucleic Acid)
6.	purine
7.	Mycophenolic Acid
8.	Transferases
9.	Enzymes
10.	RNA (Ribonucleic Acid)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Heterologous Transplantation (Xenotransplantation)
5.	Intraperitoneal Injections