IMP Dehydrogenase

An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC
Also Known As:
Inosine-5-Monophosphate Dehydrogenase; Acid Dehydrogenase, Inosinic; Dehydrogenase, IMP; Dehydrogenase, Inosine-5-Monophosphate; Dehydrogenase, Inosinic Acid; Inosine 5 Monophosphate Dehydrogenase; Inosinic Acid Dehydrogenase; IMP:NAD+ oxidoreductase
Networked: 115 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Hall, I H: 6 articles (07/2001 - 07/2000)
2. Hedstrom, Lizbeth: 4 articles (01/2014 - 08/2005)
3. Barnes, B J: 4 articles (07/2001 - 04/2001)
4. Izydore, R A: 4 articles (07/2001 - 01/2001)
5. Warren, A E: 3 articles (07/2001 - 01/2001)
6. Wheaton, J R: 3 articles (07/2001 - 01/2001)
7. Mizushina, Yoshiyuki: 2 articles (08/2013 - 01/2009)
8. Takeuchi, Toshifumi: 2 articles (08/2013 - 01/2009)
9. Yoshida, Hiromi: 2 articles (08/2013 - 01/2009)
10. Sugawara, Fumio: 2 articles (08/2013 - 01/2009)

Related Diseases

1. Infection
07/01/2015 - "When mice were immunized with an attenuated mutant strain into which IMP dehydrogenase had been inserted with a transposon, they were protected against V. vulnificus infection. "
12/01/2011 - "IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice."
08/01/2006 - "Our data do not support the use of ribavirin or other IMP dehydrogenase inhibitors for treating SARS infections in humans."
08/01/2006 - "Because of the conflicting data concerning the SARS-CoV inhibitory efficacy of ribavirin, an inosine monophosphate (IMP) dehydrogenase inhibitor, studies were done to evaluate the efficacy of ribavirin and other IMP dehydrogenase inhibitors (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR), mizoribine, and mycophenolic acid) in preventing viral replication in the lungs of BALB/c mice, a replication model for severe acute respiratory syndrome (SARS) infections (Subbarao, K., McAuliffe, J., Vogel, L., Fahle, G., Fischer, S., Tatti, K., Packard, M., Shieh, W.J., Zaki, S., Murphy, B., 2004. "
08/01/2014 - "We evaluated the potency of bafilomycin (BAF; inhibitor of vacuolar H+-ATPase (vATPase)), mycophenolic acid (MPA; inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH)), castanospermine (CAS; inhibitor of glucosidase), and deoxynojirimycin (DNJ; inhibitor of glucosidase) in blocking DENV infection of the mosquito midgut, using various treatment methods that included direct injection, ingestion by sugar feeding or blood feeding, and silencing of target genes by RNA interference (RNAi). "
2. Severe Acute Respiratory Syndrome
3. Hepatocellular Carcinoma (Hepatoma)
4. Neoplasms (Cancer)
5. Leukemia

Related Drugs and Biologics

1. tiazofurin
2. Ribavirin (Virazole)
3. Inosine Monophosphate (IMP)
4. Guanosine Triphosphate (GTP)
5. DNA (Deoxyribonucleic Acid)
6. purine
7. Mycophenolic Acid
8. Transferases
9. Enzymes
10. RNA (Ribonucleic Acid)

Related Therapies and Procedures

1. Transplantation (Transplant Recipients)
2. Drug Therapy (Chemotherapy)
3. Aftercare (After-Treatment)
4. Heterologous Transplantation (Xenotransplantation)
5. Intraperitoneal Injections