Immunosorbents

An insoluble support for an ANTIGEN or ANTIBODIES that is used in AFFINITY CHROMATOGRAPHY to adsorb the homologous antibody or antigen from a mixture. Many different substances are used, among them SEPHAROSE; GLUTARALDEHYDE; copolymers of ANHYDRIDES; polyacrylamides, etc.

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Networked: 18278 relevant articles (298 outcomes, 1377 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Zhang, Wei: 25 articles (11/2022 - 02/2003)
2.	Wang, Wei: 25 articles (01/2022 - 03/2002)
3.	Li, Jing: 24 articles (10/2022 - 08/2004)
4.	Li, Li: 24 articles (01/2022 - 02/2003)
5.	Zhang, Li: 21 articles (05/2022 - 01/2003)
6.	Xuan, Xuenan: 20 articles (12/2020 - 09/2002)
7.	Wang, Li: 18 articles (01/2022 - 04/2006)
8.	Igarashi, Ikuo: 18 articles (11/2019 - 09/2002)
9.	Zhang, Yan: 17 articles (12/2021 - 10/2004)
10.	Wang, Yan: 17 articles (11/2021 - 08/2004)

Related Diseases

1.	Infections 04/01/2020 - "Existing immunosorbents are nonselective and increase the risk of infection. " 06/01/2011 - "HTLV-1 infection was positive in 7.2% (35/483) of the participants according to the results of enzymelinked immunosorbent assay (ELISA) and western blot (WB) tests. " 07/01/2007 - "Signals of HBV infection were tested by solid-phase reverse immunosorbent test. " 01/01/1993 - "The aim of this investigation was to determine the time of toxoplasma infection more precisely by using an indirect fluorescent antibody test and indirect hemagglutination test in 51 pregnant women whose Sabin-Feldman test and immunosorbent agglutination assay were positive. " 01/01/1992 - "Prevalence of hepatitis C virus infections in dialysis patients and their contacts using a second generation enzymed-linked immunosorbent assay."
2.	Neoplasms (Cancer) 05/01/1977 - "The degree of increased tumor localization of affinity-purified antibody was similar to its improved immunoreactivity as observed in radioimmunoassay and binding to CEA immunoadsorbent. " 01/01/2023 - "Under optimal conditions, the CPXD-AD-based fluorescence-linked immunosorbent assay (FLISA) was successfully established and used for both qualitative and quantitative detection of tumor-derived exosomes." 12/27/2022 - "This strategy offers a way to construct an efficient nanozyme-linked immunosorbent assay system for the diagnosis of cancer through the highly sensitive SERS identification of exosomes." 09/01/2022 - "In this research, we develop a fluorescent approach for the identification of rare tumor cells based on a combination of immunosorbent capture and a three-step signal amplification strategy. " 01/01/2018 - "Conclusion: Compared to conventional staining methods, which are laborious (e.g., over 30 min is needed for antibody-based immunosorbent assays) and complex (e.g., diagnosis is based on discrimination of the nucleus morphology of cancer cells from that of normal cells), our probe, with its simplicity and quickness, might become a promising candidate for tumor-section staining as well as fluorescence imaging-guided surgery."
3.	Tuberculosis (Tuberculoses) 01/01/1992 - "The efficacy of enzyme-linked immunosorbent assay (ELISA) was evaluated in the sera of 215 individuals as a diagnostic aid in abdominal tuberculosis. " 04/01/1990 - "The efficacy of enzyme-linked immunosorbent assay (ELISA) in the diagnosis of gut tuberculosis was evaluated. " 03/01/2007 - "The diagnostic value of the PGL-Tb1 enzyme-linked immunosorbent assays (ELISA) was established following a survey study using sera from 220 Tuberculosis patients (including 69 HIV coinfected) and 324 controls. " 01/01/1994 - "This study was set in a general, university hospital in the Canary Islands, with the objective to evaluate an enzyme-linked immunosorbent assay (ELISA) using A60 in the serodiagnosis of tuberculosis. " 01/01/2023 - "Development of an enzyme-linked immunosorbent assay for the diagnosis of feline tuberculosis."
4.	Inflammation (Inflammations) 12/01/2023 - "Finally, enzym-linked immunosorbent assay (ELISA) was used to verify that AA could reduce inflammation after TBI. " 01/01/2022 - "Enzyme linked immunosorbent assay (ELISA) was performed to evaluate the inflammation level as well as the SDF-1 levels in the infarcted border zone of the heart. " 01/01/2021 - "Reverse transcription‑quantitative PCR, enzymy‑linked immunosorbent assay, western blotting and immunofluorescence staining were performed to detect the expressions of inflammation related factors and adhesion molecules. " 04/01/2016 - "The inflammation of LPS‑stimulated synoviocytes and CIA rats was assessed using enzyme‑linked immunosorbent assays and western blotting. " 02/06/2021 - "Subsequently, lung injury and inflammation were evaluated by histology and enzyme‑linked immunosorbent assay (ELISA), respectively. "
5.	Necrosis 04/09/2021 - "目的： 探讨粪肠球菌培养上清液诱导人牙周膜细胞（human periodontal ligament cell，hPDLC）的炎症反应及其在压力状态下的表达变化。 方法： 噻唑蓝（methyl thiazolyl tetrazolium，MTT）法检测不同体积分数［0%（对照组）、1%、2%、5%、10%和20%］的粪肠球菌上清液对hPDLC增殖活性的影响，采用流式细胞术检测粪肠球菌上清液刺激24 h后hPDLC表面Toll样受体2（Toll-like receptor 2，TLR-2）表达的改变；依据MTT及流式细胞术结果，将hPDLC分为不含粪肠球菌上清液的非诱导组与含5%粪肠球菌上清液的诱导组，每组均分别加载0、49及196 Pa的静压力，非诱导组和诱导组均以未加力（0 Pa）状态为对照。24 h 后观察hPDLC的形态变化，通过反转录PCR（reverse transcription-PCR，RT-PCR）和酶联免疫吸附测定（enzyme linked immunosorbent assay，ELISA）法检测hPDLC肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）及白介素-1β（interleukin-1β，IL-1β）的mRNA和蛋白表达水平。 结果： MTT法结果显示，培养48 h时，与对照组相比体积分数≥5%的粪肠球菌上清液能显著降低hPDLC的增殖活性（P<0.05）。流式细胞术结果显示，粪肠球菌上清液刺激hPDLC 24 h后其表面TLR-2阳性细胞率随上清液体积分数的增加而增加，0%、1%、2%、5%、10%和20%体积分数的上清液TLR-2阳性细胞率分别为（2.12±0.07）%、（2.41±0.32）%、（2.65±0.27）%、（4.76±0.46）%、（9.91±0.92）%、（12.01±1.35）%，体积分数≥5%时与对照组相比差异均有统计学意义（P<0.05）。RT-PCR结果显示，非诱导组施加49 Pa压力时，hPDLC IL-1β和TNF-α mRNA表达与对照组相比差异均无统计学意义（P>0.05），施加196 Pa压力时，hPDLC IL-1β和TNF-α mRNA表达与对照组相比差异均有统计学意义（P<0.05）；而诱导组施加49和196 Pa压力时，hPDLC IL-1β和TNF-α mRNA表达均显著升高，与对照组相比差异均有统计学意义（P<0.05）。ELISA结果与PCR结果趋势一致。 结论： 高浓度的粪肠球菌上清液能抑制hPDLC的增殖活性；粪肠球菌上清液可以促进hPDLC表面TLR-2的表达；过度的机械压力可引起hPDLC细胞的炎症反应，导致hPDLC对压力不耐受，引起炎症反应加重。." 02/20/2017 - "背景与目的 T肽是Tuftsin的衍生物，其基本功能是刺激巨噬细胞，提高巨噬细胞吞噬及分泌能力，通过增强效应细胞的细胞杀伤作用而被广泛用于多种恶性肿瘤术后抗肿瘤治疗。本研究旨在探讨T肽与化疗药物顺铂的联合能否提高铂类药物的抗肿瘤疗效及机制。方法 应用酶联免疫吸附剂测定（enzyme-linked immunosorbent assay, ELISA）T肽和/或顺铂处理人巨噬细胞株U937后肿瘤坏死因子-α（tumor necrosis factor-α, TNF-α）和干扰素-γ（interferon-γ, IFN-γ）分泌水平的变化；应用裸鼠荷瘤动物模型，分析T肽和/或顺铂处理小鼠肿瘤变化情况以及小鼠用药期间外周血中巨噬细胞变化情况。结果 ①应用ELISA检测发现在T肽组和T肽联合顺铂组中，U937细胞培养液中TNF-α水平明显高于对照组和顺铂组；T肽联合顺铂组中IFN-γ水平明显高于对照组、顺铂组和T肽组；②在小鼠荷瘤模型中，T肽联合顺铂组的肿瘤体积明显小于对照组、顺铂组和T肽组，并且小鼠没有明显的体重下降；③在小鼠外周血的检测分析中发现，T肽联合顺铂组中活化巨噬细胞数呈现增长趋势。免疫组化分析各组中肿瘤组织Ki67显示T肽联合顺铂组抑制肿瘤细胞增殖。结论 T肽能够促进巨噬细胞增殖和促进其分泌肿瘤细胞杀伤因子（TNF-α、IFN-γ）；在体内动物模型中，T肽能够提高化疗药物如顺铂的疗效，使联合组具有更强的肿瘤抑制作用，同时能够减轻化疗药物的毒副作用。." 11/01/2017 - "Inflammatory factor interleukin‑13 (IL‑13) and tumor necrosis factor‑α (TNF‑α) levels in serum and bronchoalveolar lavage fluid (BALF) were determined by enzyme‑linked immunosorbent assay. " 05/01/2017 - "Furthermore, enzyme‑linked immunosorbent assay analysis showed that OA significantly decreased the levels of tumor necrosis factor‑α and transforming growth factor‑β1. " 02/01/1990 - "Improvement in sensitivity of enzyme-linked immunosorbent assay for tumour necrosis factor."

Related Drugs and Biologics

1.	Enzymes
2.	Antigens
3.	Antibodies
4.	Immunoglobulin G (IgG)
5.	Immunoglobulin M (IgM)
6.	Proteins (Proteins, Gene)
7.	Vaccines
8.	Cytokines
9.	Immunoglobulin A (IgA)
10.	Autoantibodies

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Plasmapheresis
4.	Drug Therapy (Chemotherapy)
5.	Blood Component Removal (Apheresis)