Immunoglobulin mu-Chains (mu-Chain, Immunoglobulin)

The class of heavy chains found in IMMUNOGLOBULIN M. They have a molecular weight of approximately 72 kDa and they contain about 57 amino acid residues arranged in five domains and have more oligosaccharide branches and a higher carbohydrate content than the heavy chains of IMMUNOGLOBULIN G.

Also Known As:

mu-Chain, Immunoglobulin; Immunoglobulin mu-Chain; mu Immunoglobulin Heavy Chain; mu Immunoglobulin Heavy Chains; mu-Chain Immunoglobulins; Chains, Ig mu; Immunoglobulin mu Chain; Immunoglobulin mu Chains; Immunoglobulins, mu Chain; mu Chain Immunoglobulins; mu Chains, Ig; mu-Chains, Immunoglobulin; Ig mu Chains; Immunoglobulins, mu-Chain

Networked: 26 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Immunoglobulin Isotypes: 1085
        Immunoglobulin M: 26578
        Immunoglobulin mu-Chains: 26
        human IGHM protein
        Immunoglobulin Subunits: 40
        Immunoglobulin Heavy Chains: 1667
        Immunoglobulin mu-Chains: 26
        human IGHM protein
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Immunoglobulin Isotypes: 1085
        Immunoglobulin M: 26578
        Immunoglobulin mu-Chains: 26
        human IGHM protein
        Immunoglobulin Subunits: 40
        Immunoglobulin Heavy Chains: 1667
        Immunoglobulin mu-Chains: 26
        human IGHM protein
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Immunoglobulin Isotypes: 1085
        Immunoglobulin M: 26578
        Immunoglobulin mu-Chains: 26
        human IGHM protein
        Immunoglobulin Subunits: 40
        Immunoglobulin Heavy Chains: 1667
        Immunoglobulin mu-Chains: 26
        human IGHM protein

Experts

1.	Daheshia, M: 1 article (04/2000)
2.	Deshpande, S P: 1 article (04/2000)
3.	Rouse, B T: 1 article (04/2000)
4.	Zheng, M: 1 article (04/2000)

Related Diseases

1.	Plasmacytoma 06/01/1988 - "Alternative expression of secreted and membrane forms of immunoglobulin mu-chain is regulated by transcriptional termination in stable plasmacytoma transfectants." 12/11/1982 - "We describe the unique features of an aberrantly rearranged mu immunoglobulin heavy chain gene isolated from MPC-11 cells (a gamma 2b producing Balb/c plasmacytoma). " 04/27/1984 - "The productively rearranged immunoglobulin mu chain gene and the translocated cellular oncogene c-myc are transcribed at high levels both in human Burkitt lymphoma cells carrying the t(8;14) chromosome translocation and in mouse plasmacytoma X Burkitt lymphoma cell hybrids. " 01/01/1980 - "To elucidate the structure of the gene for the constant region of immunoglobulin mu chains, we have cloned a 9.9-kilobase-pair fragment of mouse DNA bearing a gene for the constant region of the mu chain (C mu gene) from an IgM-secreting mouse plasmacytoma. "
2.	Narcolepsy 01/01/1992 - "This gene may be related to the mu-immunoglobulin heavy-chain switch-like segment that has been implicated in canine narcolepsy. " 04/15/1991 - "Genetic linkage of autosomal recessive canine narcolepsy with a mu immunoglobulin heavy-chain switch-like segment." 07/01/1996 - "Canine narcolepsy is not linked with DLA, the canine equivalent of HLA, but co-segregates with a DNA segment with high homology with the mu immunoglobulin heavy-chain (IgH) switch-like region (S mu). "
3.	Burkitt Lymphoma (Burkitt's Lymphoma) 10/01/1988 - "Burkitt's lymphoma cell lines producing truncated mu immunoglobulin heavy chains lacking part of the variable region." 12/22/1983 - "Transcription enhancer identified near the human C mu immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma." 04/27/1984 - "The productively rearranged immunoglobulin mu chain gene and the translocated cellular oncogene c-myc are transcribed at high levels both in human Burkitt lymphoma cells carrying the t(8;14) chromosome translocation and in mouse plasmacytoma X Burkitt lymphoma cell hybrids. "
4.	Neoplasms (Cancer) 08/01/1984 - "Sparse amounts of cytoplasmic mu-immunoglobulin heavy chains were present in most of these cells, suggesting that the tumor originated in pre-B-lymphocytes. " 08/05/2022 - "Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. "
5.	Leukemia 12/15/1993 - "This effect could be mimicked by cross-linking the leukemia cells' surface IgM receptors with immobilized murine mAb specific for human Ig mu-chains, but not by immobilized mAb of irrelevant specificity. " 08/01/1989 - "Leukemic cell populations classified as belonging to the B lineage according to their surface antigenic patterns revealed increasing expression of mRNA for the IgM heavy chain (mu mRNA) in a maturation-dependent fashion, which was not correlated to rearrangement of the immunoglobulin mu chain gene--only 66% of the leukemias with rearranged mu gene also transcribed it. "

Related Drugs and Biologics

1.	Immunoglobulin M (IgM)
2.	Antibodies
3.	A-Form DNA (A-DNA)
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	DNA (Deoxyribonucleic Acid)
7.	Concanavalin A
8.	Amino Acids
9.	Interferon gamma Receptor
10.	immunoglobulin M receptor