Immunoglobulin Light Chains (Immunoglobulin Light Chain)

Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.

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Networked: 752 relevant articles (17 outcomes, 47 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gertz, Morie A: 50 articles (01/2016 - 01/2002)
2.	Dispenzieri, Angela: 42 articles (01/2016 - 01/2002)
3.	Merlini, Giampaolo: 25 articles (11/2015 - 06/2002)
4.	Lacy, Martha Q: 23 articles (01/2016 - 01/2002)
5.	Seldin, David C: 23 articles (11/2014 - 03/2003)
6.	Leung, Nelson: 20 articles (08/2015 - 07/2005)
7.	Hayman, Suzanne R: 18 articles (01/2016 - 11/2005)
8.	Ramirez-Alvarado, Marina: 17 articles (12/2015 - 07/2006)
9.	Palladini, Giovanni: 17 articles (10/2015 - 04/2004)
10.	Dingli, David: 15 articles (01/2016 - 10/2009)

Related Diseases

1.	Amyloidosis 06/01/2011 - "Recent advances in the treatment of immunoglobulin light chain amyloidosis (AL) have dramatically improved survival. " 06/01/2012 - "Herein, we demonstrate a case of treated immunoglobulin light chain cardiac amyloidosis with echocardiographic wall thinning and cardiac biopsies demonstrating complete histologic remission. " 08/01/2014 - "Patient survival is superior to renal immunoglobulin light chain-derived amyloidosis and reactive amyloidosis largely due to the absence of cardiac involvement. " 04/01/2009 - "No therapy is uniformly effective in the management of immunoglobulin light chain amyloidosis (AL amyloidosis). " 06/01/2015 - "Natural history and outcomes in localised immunoglobulin light-chain amyloidosis: a long-term observational study."
2.	Multiple Myeloma 05/01/1993 - "These findings indicate that comparison of histological and cytological results with immunohistological studies for immunoglobulin light chains in bone marrow biopsy sections can be helpful in the evaluation of patients with a suspicion of multiple myeloma and when the marrow contains less than 10% of plasma cells." 08/01/2014 - "High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS." 03/01/2012 - "We have previously described the use of the 3' κ immunoglobulin light chain enhancer (3'KE) to target transgenic expression in murine B and plasma cells, resulting in bcl-X(L) and c-myc-driven murine models of multiple myeloma. " 09/01/2006 - "Multiple myeloma represents a malignant proliferation of plasma cells in the bone marrow, which often overproduces immunoglobulin light chains. " 07/01/2005 - "Subsequent tests revealed multiple myeloma confirmed by bone marrow biopsy and identification of a monoclonal kappa light chain immunoglobulin by serum and urine immunoelectrophoresis and immunofixation. "
3.	Lymphoma (Lymphomas) 01/01/2001 - "The expression pattern of immunoglobulin light chains was not found helpful in favoring one lymphoma type over another. " 09/01/2010 - "The aim of this study was to find out a potential diagnostic value of free immunoglobulin light chains released into the CSF of CNS lymphoma patients. " 08/01/1985 - "The results of the study, however, suggest that the development of lymphoma with expression of a different immunoglobulin light chain may not necessarily indicate the occurrence of a second primary. " 11/01/2014 - "Evaluation diagnostic usefulness of immunoglobulin light chains (Igκ, Igλ) and incomplete IGH D-J clonal gene rearrangements in patients with B-cell non-Hodgkin lymphomas using BIOMED-2 protocol." 03/01/2014 - "We searched a consecutive series of CSF specimens submitted to our laboratory for polychromatic (8-color) flow cytometric immunophenotyping between June, 2010 and December, 2012 for cases in which a B-cell population with monotypic immunoglobulin light chain expression was detected in patients without clinical or radiographic evidence of lymphoma. "
4.	Neoplasms (Cancer) 03/01/1994 - "Immunohistochemical study revealed that both neoplasms have the same immunoglobulin light chain type (kappa-light chain). " 11/01/2015 - "Intense cytoplasmic expression of a restricted immunoglobulin light chain was significantly more frequent in SOX11-negative than -positive tumors (58 vs 13%) (P=0.001). " 01/01/2015 - "Antibody clonality of B cells derived from tumor and lymph node was determined by analyzing heavy and light chain immunoglobulin sequences. " 07/01/2013 - "Our results demonstrated that the expression of Prx IV was induced as cells became competent to synthesize immunoglobulin light chains, as observed by immunohistochemistry in tissue sections of B cell neoplasms and also by qPCR and Western blotting analyses in malignant B cell lines. " 01/01/2012 - "For differentiating reactive plasmacytosis from clonal plasma cell (PC) neoplasms such as PCM, it is important to accurately determine the expression of cytoplasmic immunoglobulin light chains. "
5.	Pseudolymphoma 05/01/2013 - "A group of these lesions correspond to atypical lymphoid hyperplasias, including follicular hyperplasias, atypical marginal zone hyperplasias, and florid reactive lymphoid hyperplasias of the lower female genital tract in which immunoglobulin light chain restriction with or without clonal IGH rearrangements may be found in some cases. " 06/01/2006 - "MALT-type lymphoma demonstrated characteristic negative staining for CD3, CD5 and CD43, positive staining for CD20, and monotypic staining for either kappa or lambda light chain immunoglobulin markers, whereas reactive lymphoid hyperplasia all expressed B and T cell markers. " 04/01/2000 - "All cases of reactive lymphoid hyperplasia were DNA diploid and showed a polyclonal expression of immunoglobulin light chains. " 08/01/2001 - "The histologic distinction of myoepithelial sialadenitis from low-grade B-cell mucosa-associated lymphoid tissue lymphoma can be a difficult diagnostic challenge and many of these lesions continue to be ambiguously diagnosed as "pseudolymphoma." Immunophenotypic or flow cytometric analysis may be useful in showing an aberrant phenotype or immunoglobulin light-chain restriction, which helps to support a diagnosis of malignant lymphoma in most cases. " 04/01/1986 - "Although follow-up was short or inconclusive in some patients with lymphoma and pseudolymphoma, it was concluded that evaluation of T and B cell antigens and immunoglobulin light chains in frozen tissue is helpful in classifying lymphocytic neoplasms, especially in cases without definite cytologic evidence of malignancy. "

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3.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
4.	Aftercare (After-Treatment)
5.	Hematopoietic Stem Cell Transplantation