Immunoglobulin Light Chains (Immunoglobulin Light Chain)

Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.
Also Known As:
Immunoglobulin Light Chain; Immunoglobulin Light-Chain; Light-Chain Immunoglobulins; Chains, Immunoglobulin Light; Immunoglobulins, Light Chain; Light Chain Immunoglobulins; Light Chain, Immunoglobulin; Light Chains, Immunoglobulin; Light-Chain, Immunoglobulin; Immunoglobulins, Light-Chain
Networked: 752 relevant articles (17 outcomes, 47 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Gertz, Morie A: 50 articles (01/2016 - 01/2002)
2. Dispenzieri, Angela: 42 articles (01/2016 - 01/2002)
3. Merlini, Giampaolo: 25 articles (11/2015 - 06/2002)
4. Lacy, Martha Q: 23 articles (01/2016 - 01/2002)
5. Seldin, David C: 23 articles (11/2014 - 03/2003)
6. Leung, Nelson: 20 articles (08/2015 - 07/2005)
7. Hayman, Suzanne R: 18 articles (01/2016 - 11/2005)
8. Ramirez-Alvarado, Marina: 17 articles (12/2015 - 07/2006)
9. Palladini, Giovanni: 17 articles (10/2015 - 04/2004)
10. Dingli, David: 15 articles (01/2016 - 10/2009)

Related Diseases

1. Amyloidosis
2. Multiple Myeloma
3. Lymphoma (Lymphomas)
4. Neoplasms (Cancer)
5. Pseudolymphoma
05/01/2013 - "A group of these lesions correspond to atypical lymphoid hyperplasias, including follicular hyperplasias, atypical marginal zone hyperplasias, and florid reactive lymphoid hyperplasias of the lower female genital tract in which immunoglobulin light chain restriction with or without clonal IGH rearrangements may be found in some cases. "
06/01/2006 - "MALT-type lymphoma demonstrated characteristic negative staining for CD3, CD5 and CD43, positive staining for CD20, and monotypic staining for either kappa or lambda light chain immunoglobulin markers, whereas reactive lymphoid hyperplasia all expressed B and T cell markers. "
04/01/2000 - "All cases of reactive lymphoid hyperplasia were DNA diploid and showed a polyclonal expression of immunoglobulin light chains. "
08/01/2001 - "The histologic distinction of myoepithelial sialadenitis from low-grade B-cell mucosa-associated lymphoid tissue lymphoma can be a difficult diagnostic challenge and many of these lesions continue to be ambiguously diagnosed as "pseudolymphoma." Immunophenotypic or flow cytometric analysis may be useful in showing an aberrant phenotype or immunoglobulin light-chain restriction, which helps to support a diagnosis of malignant lymphoma in most cases. "
04/01/1986 - "Although follow-up was short or inconclusive in some patients with lymphoma and pseudolymphoma, it was concluded that evaluation of T and B cell antigens and immunoglobulin light chains in frozen tissue is helpful in classifying lymphocytic neoplasms, especially in cases without definite cytologic evidence of malignancy. "

Related Drugs and Biologics

1. Melphalan (Alkeran)
2. Amyloid (Amyloid Fibrils)
3. Dexamethasone (Maxidex)
4. Antigens
5. Muramidase (Lysozyme)
6. Troponin
7. CD45 Antigens (CD45 Antigen)
8. von Willebrand Factor
9. Vincristine (Oncovin)
10. Pancreatic Elastase (Elastase)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Stem Cell Transplantation
3. Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
4. Aftercare (After-Treatment)
5. Hematopoietic Stem Cell Transplantation