Immunoglobulin lambda-Chains

One of the types of light chain subunits of the immunoglobulins with a molecular weight of approximately 22 kDa.

Also Known As:

Immunoglobulin lambda-Chain; lambda-1-Immunoglobulin; lambda-2-Immunoglobulin; lambda-Chain Immunoglobulins; lambda-Immunoglobulin Light Chain; lambda-Immunoglobulin Light Chains; lambda-x Immunoglobulin; Chains, Ig lambda; Chains, lambda-Immunoglobulin Light; Immunoglobulin lambda Chain; Immunoglobulin lambda Chains; Immunoglobulin, lambda-x; Immunoglobulins, lambda Chain; Light Chain, lambda-Immunoglobulin; Light Chains, lambda-Immunoglobulin; lambda 1 Immunoglobulin; lambda 2 Immunoglobulin; lambda Chain Immunoglobulins; lambda Chains, Ig; lambda Immunoglobulin Light Chain; lambda Immunoglobulin Light Chains; lambda x Immunoglobulin; lambda-Chain, Immunoglobulin; lambda-Chains, Immunoglobulin; Ig lambda Chains; Immunoglobulins, lambda-Chain

Networked: 34 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Immunoglobulin Subunits: 40
        Immunoglobulin Light Chains: 1132
        Immunoglobulin lambda-Chains: 34
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Immunoglobulin Subunits: 40
        Immunoglobulin Light Chains: 1132
        Immunoglobulin lambda-Chains: 34
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Immunoglobulin Subunits: 40
        Immunoglobulin Light Chains: 1132
        Immunoglobulin lambda-Chains: 34

Experts

1.	Clark, Raynell J: 2 articles (01/2008 - 08/2005)
2.	Dispenzieri, Angela: 2 articles (01/2008 - 08/2005)
3.	Gertz, Morie A: 2 articles (01/2008 - 01/2007)
4.	Katzmann, Jerry A: 2 articles (01/2008 - 08/2005)
5.	Kyle, Robert A: 2 articles (01/2008 - 08/2005)
6.	Melton, L Joseph: 2 articles (01/2008 - 08/2005)
7.	Rajkumar, S Vincent: 2 articles (01/2008 - 08/2005)
8.	Therneau, Terry M: 2 articles (01/2008 - 08/2005)
9.	Garus, Bartosz: 1 article (02/2022)
10.	Grywalska, Ewelina: 1 article (02/2022)

Related Diseases

1.	Lymphoma (Lymphomas) 01/01/2015 - "The system can detect scant lymphoma cells and quantitate their kappa/lambda immunoglobulin light chain restriction patterns. " 09/01/2010 - "B-cell lymphomas such as CNS lymphomas are clonally restricted and express either kappa or lambda immunoglobulin light chains. " 06/01/2006 - "To increase awareness of the existence of the dual kappa/lambda immunoglobulin light-chain expressing B-cell leukemia/lymphoma, to emphasize the importance of visual inspection of flow cytometric data, and to present the guidelines for flow cytometric interpretation of dual kappa/lambda coexpressing populations. " 04/08/2004 - "Lymphomas with integrations at Ebfaz or Evi3 express the pre-B-cell-specific marker immunoglobulin lambda chain 5, and contain immunoglobulin heavy-chain rearrangements, suggesting that they are blocked at an early B-cell stage. " 12/01/1997 - "Immunocytochemical stains were performed in five cases using the following antibodies: L26 (Pan B), UCHL1 (Pan T), kappa and lambda immunoglobulin light chains (three cases) in order to distinguish inflammatory pseudotumours from low-grade non-Hodgkin's lymphomas. "
2.	Amyloidosis 02/09/2022 - "AL (light-chain) amyloidosis is a systemic disease in which amyloid fibers are formed from kappa or lambda immunoglobulin light chains, or fragments thereof, produced by a neoplastic clone of plasmocytes. " 01/01/1991 - "There is a possibility that some components of amyloid in some cases of primary localized cutaneous nodular amyloidosis may consist of both kappa and lambda immunoglobulin light chains." 07/01/2009 - "The classification of amyloidosis was made by immunofluorescence and immunohistochemical staining with antibodies to kappa and lambda immunoglobulin light chains, and for serum amyloid A protein. " 06/01/2007 - "The classification of amyloidosis is made by immunostaining with antibodies to kappa and lambda immunoglobulin light chains and for serum amyloid A protein. " 07/01/1981 - "Characterization of an amyloid fibril protein from localized amyloidosis of the skin as lambda immunoglobulin light chains of variable subgroup I (A lambda I)."
3.	Plasmacytoma 09/01/1991 - "Excisional biopsy of the lesion revealed a plasmacytoma which produced a monoclonal lambda chain immunoglobulin. " 10/16/1980 - "Additional somatic mechanisms probably also contribute to the ultimate heterogeneity; one-third of murine plasmacytomas producing lambda 1 immunoglobulin carry a somatically mutated Ig1-V gene. " 04/15/1983 - "The post-translational fates of three immunoglobulin lambda chain variants of MOPC 315 were investigated in mouse plasmacytoma cell lines and in mRNA-microinjected Xenopus oocytes. " 08/01/2007 - "The amyloid deposits were also shown to be reactive with lambda immunoglobulin light chain, suggesting the pathogenetic relationship between the plasmacytoma and amyloid deposition in the larynx. "
4.	Amyloid Plaque 08/01/2007 - "The amyloid deposits were also shown to be reactive with lambda immunoglobulin light chain, suggesting the pathogenetic relationship between the plasmacytoma and amyloid deposition in the larynx. " 08/01/2018 - "Our results showed that Tat peptide binds amyloid deposits made up of Aβ, PrP, and immunoglobulin lambda chains in the brain and other tissues processed by alcoholic fixatives but not in formalin-fixed tissue. "
5.	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 06/01/2009 - "We report the first case in Korea of lambda-expressing MALT lymphoma that is shown to have dual clonal rearrangements of kappa and lambda immunoglobulin light chain gene by multiplex PCR." 06/01/2009 - "[A case of lambda-expressing pulmonary MALT lymphoma with dual clonal rearrangements of kappa and lambda immunoglobulin light chain gene]." 12/01/2006 - "Several balanced translocations have been identified in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) but there are few data regarding their frequency in different anatomic sites or the frequency of translocations involving BCL6 or kappa or lambda immunoglobulin light chain genes (IGK or IGL), particularly in patients from geographic regions other than Europe and Japan. "

Related Drugs and Biologics

1.	Antibodies
2.	Amyloid (Amyloid Fibrils)
3.	Proteins (Proteins, Gene)
4.	Muramidase (Lysozyme)
5.	Formaldehyde (Formol)
6.	Serum Amyloid A Protein (Serum Amyloid A)
7.	Lipocalin 1
8.	Clusterin
9.	Protein Isoforms (Isoforms)
10.	Cyclin D1