Immunoglobulin kappa-Chains (kappa-Chain, Immunoglobulin)

One of the types of light chains of the immunoglobulins with a molecular weight of approximately 22 kDa.

Also Known As:

kappa-Chain, Immunoglobulin; Immunoglobulin kappa-Chain; kappa-Chain Immunoglobulins; kappa-Immunoglobulin Light Chain; kappa-Immunoglobulin Subgroup VK-12; kappa-Immunoglobulin Subgroup VK-21; Chains, Ig kappa; Immunoglobulin kappa Chain; Immunoglobulin kappa Chains; Immunoglobulins, kappa Chain; Light Chain, kappa-Immunoglobulin; Light Chains, kappa-Immunoglobulin; kappa Chain Immunoglobulins; kappa Chains, Ig; kappa Immunoglobulin Light Chain; kappa Immunoglobulin Light Chains; kappa Immunoglobulin Subgroup VK 12; kappa Immunoglobulin Subgroup VK 21; kappa-Chains, Immunoglobulin; Ig kappa Chains; Immunoglobulins, kappa-Chain; kappa-Immunoglobulin Light Chains

Networked: 39 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Immunoglobulin Subunits: 40
        Immunoglobulin Light Chains: 1132
        Immunoglobulin kappa-Chains: 39
        Immunoglobulin Km Allotypes: 52
        amyloid protein BAN: 1
        myeloma-associated membrane antigen KMA: 1
        human amyloid protein GRA
        rabbits kappa allotype b4
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Immunoglobulin Subunits: 40
        Immunoglobulin Light Chains: 1132
        Immunoglobulin kappa-Chains: 39
        Immunoglobulin Km Allotypes: 52
        amyloid protein BAN: 1
        myeloma-associated membrane antigen KMA: 1
        human amyloid protein GRA
        rabbits kappa allotype b4
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Immunoglobulin Subunits: 40
        Immunoglobulin Light Chains: 1132
        Immunoglobulin kappa-Chains: 39
        Immunoglobulin Km Allotypes: 52
        amyloid protein BAN: 1
        myeloma-associated membrane antigen KMA: 1
        human amyloid protein GRA
        rabbits kappa allotype b4

Experts

1.	Chen, Carl P C: 2 articles (12/2020 - 01/2017)
2.	Chen, Jean-Lon: 2 articles (12/2020 - 01/2017)
3.	Hsu, Chih-Chin: 2 articles (12/2020 - 01/2017)
4.	Huang, Shu-Chun: 1 article (12/2020)
5.	Lin, Mu-Yun: 1 article (12/2020)
6.	Lin, Shin-Yi: 1 article (12/2020)
7.	Chi, Y T: 1 article (11/2020)
8.	Li, B B: 1 article (11/2020)
9.	Liu, C L: 1 article (11/2020)
10.	Zhang, Q L: 1 article (11/2020)

Related Diseases

1.	Plasmacytoma 09/01/2020 - "Chromogenic in situ hybridization for the detection of lambda and kappa immunoglobulin light chains as a potential auxiliary diagnostic technique in canine plasmacytomas." 07/01/1985 - "DNA fragments containing immunoglobulin kappa-chain sequences from two different plasmacytomas (PC 3609 and PC 7043) were found by blot-hybridization studies to be dissociated from germ-line sequences on both the 3' and 5' ends. " 10/01/1988 - "The nuclear extracts of plasmacytomas producing antibodies were found to contain factors which formed complexes with the promoter fragment of the gene for immunoglobulin kappa-chains. " 01/01/2001 - "The biochemical nature of the amyloid deposits was also shown to be of kappa immunoglobulin light chain, suggesting the pathogenetic relationship between the plasmacytoma and amyloid deposition in the larynx of this patient. " 06/01/1986 - "To elucidate the molecular features of active chromatin, we have mapped, by two-dimensional electrophoresis, the protein composition of nucleosomes that package the immunoglobulin kappa chain gene of mouse plasmacytoma cells. "
2.	Neoplasms (Cancer) 01/23/2010 - "Histologically, the tumor cells exhibited plasmablastic morphology with expression of Bob-1, CD4, CD10, CD45, CD56, CD138, EMA, MUM1, Oct-2, and kappa immunoglobulin light chain, but negative for CD20, CD30, CD79a, PAX-5, and lambda. " 10/01/2007 - "Underexpression of immunoglobulin kappa chain constant region was observed in the sera of tumor bearing mice compared with controls (2.5-fold, P < or = 0.05). " 01/01/1987 - "The endogenous mouse mammary tumor provirus (Mtv-8) previously has been reported to reside on mouse chromosome 6 near the immunoglobulin kappa chain locus. " 01/01/2007 - "Kappa immunoglobulin light chain polymorphisms and survival after allogeneic transplantation for B-cell malignancies: a potential graft-vs-leukaemia target." 10/01/2012 - "Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors."
3.	Inflammation (Inflammations) 12/01/2013 - "In tear samples of GO subjects, the protein fractions of inflammation-related protein immunoglobulin kappa chain C region (IgKC) and serum albumin were essentially reduced, whereas a novel isoform of complement component 3 (C3), which we detected in control subjects, was completely absent in the GO patients' tears. " 12/01/2020 - "Proteins associated with inflammation, such as apolipoprotein A-I, haptoglobin, immunoglobulin kappa chain, transferrin, and matrix metalloproteinase also decreased significantly. " 01/01/2017 - "Proteins associated with inflammation, such as apolipoprotein A-I, haptoglobin, immunoglobulin kappa chain, transferrin, and matrix metalloproteinase decreased at least 2-fold in concentrations. "
4.	Amyloid Plaque 12/01/2015 - "The amyloid deposits were positive for kappa immunoglobulin light chain on immunohistochemistry. " 01/01/2001 - "The biochemical nature of the amyloid deposits was also shown to be of kappa immunoglobulin light chain, suggesting the pathogenetic relationship between the plasmacytoma and amyloid deposition in the larynx of this patient. "
5.	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 04/01/1996 - "A morphologically and immunohistochemically typical, monotypical mu-kappa immunoglobulin light chain secreting B-cell MALT-lymphoma was diagnosed. " 11/10/2020 - "The positive detection rates of immunoglobulin heavy chain (IgH)-FR1, IgH-FR2, IgH-FR3, immunoglobulin kappa chain (IgK)-A, and IgK-B in SS-MALT lymphoma group were 33.3%, 53.3%, 33.3%, 20.0%, and 26.7%, respectively, and 93.3% when together used with IgH and IgK. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Proteins (Proteins, Gene)
3.	Matrix Metalloproteinases (MMPs)
4.	Apolipoprotein A-I (Apolipoprotein A1)
5.	Biomarkers (Surrogate Marker)
6.	Transferrin (beta 2 Transferrin)
7.	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)
8.	Haptoglobins
9.	Antibodies
10.	IgK

Related Therapies and Procedures

1.	Homologous Transplantation
2.	Transplantation
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)