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Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)

Subscribe to New Research on Immunoglobulin Heavy Chains

The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.

Also Known As:

Immunoglobulin Heavy Chain; Heavy Chain, Immunoglobulin; Heavy-Chain Immunoglobulins; Ig Heavy Chains; Immunoglobulin Heavy Chain Subgroup VH-I; Immunoglobulin Heavy Chain Subgroup VH-III; Heavy Chain Immunoglobulins; Heavy Chains, Ig; Heavy Chains, Immunoglobulin; Immunoglobulin Heavy Chain Subgroup VH I; Immunoglobulin Heavy Chain Subgroup VH III; Immunoglobulins, Heavy Chain; Immunoglobulins, Heavy-Chain

Networked: 1295 relevant articles (13 outcomes, 88 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Blood Proteins: 4303
    - Serum Globulins: 75
      - Immunoglobulins: 23980
        Immunoglobulin Subunits: 30
        Immunoglobulin Heavy Chains: 1295
        Immunoglobulin mu-Chains: 23
        Immunoglobulin alpha-Chains: 5
        Immunoglobulin epsilon-Chains: 2
        Immunoglobulin gamma-Chains: 2
        human HS1,2-A enhancer protein
        Immunoglobulin delta-Chains
        monoclonal antibody B23 heavy chain
        zebrafish immunoglobulin zeta
    - Immunoproteins: 33
      - Immunoglobulins: 23980
        Immunoglobulin Subunits: 30
        Immunoglobulin Heavy Chains: 1295
        Immunoglobulin mu-Chains: 23
        Immunoglobulin alpha-Chains: 5
        Immunoglobulin epsilon-Chains: 2
        Immunoglobulin gamma-Chains: 2
        human HS1,2-A enhancer protein
        Immunoglobulin delta-Chains
        monoclonal antibody B23 heavy chain
        zebrafish immunoglobulin zeta
  - Globulins: 334
    - Serum Globulins: 75
      - Immunoglobulins: 23980
        Immunoglobulin Subunits: 30
        Immunoglobulin Heavy Chains: 1295
        Immunoglobulin mu-Chains: 23
        Immunoglobulin alpha-Chains: 5
        Immunoglobulin epsilon-Chains: 2
        Immunoglobulin gamma-Chains: 2
        human HS1,2-A enhancer protein
        Immunoglobulin delta-Chains
        monoclonal antibody B23 heavy chain
        zebrafish immunoglobulin zeta

Experts

1.	Medeiros, L Jeffrey: 11 articles (04/2013 - 04/2002)
2.	Keating, Michael J: 10 articles (08/2014 - 06/2003)
3.	Nakamura, Naoya: 10 articles (07/2013 - 06/2002)
4.	Gribben, John G: 9 articles (01/2015 - 07/2002)
5.	Wierda, William G: 9 articles (08/2014 - 06/2003)
6.	Yoshino, Tadashi: 9 articles (07/2013 - 09/2004)
7.	Abe, Masafumi: 8 articles (07/2013 - 06/2002)
8.	Neri, Antonino: 8 articles (06/2013 - 02/2005)
9.	Taniwaki, Masafumi: 8 articles (04/2011 - 04/2003)
10.	Gaidano, Gianluca: 7 articles (09/2014 - 05/2002)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/01/1993 - "The PCR was used to detect monoclonal rearrangements of the immunoglobulin heavy chain and/or T-cell receptor gamma chain genes in archival marrow specimens from 185 children with acute lymphoblastic leukemia who achieved remission during two consecutive Australasian trials of treatment. " 11/01/2001 - "Absence of somatic hypermutation of immunoglobulin heavy chain variable region genes in precursor B-lymphoblastic lymphoma: a study of four cases in childhood and adolescence." 05/01/1989 - "Comparison studies of immunoglobulin heavy-chain gene rearrangements and also delta Mo + SV M-MuLV proviral integration sites confirmed that the macrophage cell line was derived from the original B-lymphoblastic lymphoma. " 01/01/2015 - "Translocations leading to fusions between the immunoglobulin heavy chain gene (IGH) and various partner genes have been reported in B-cell precursor acute lymphoblastic leukemia (B-ALL). " 01/01/2015 - "Submicroscopic deletions of immunoglobulin heavy chain gene (IGH) in precursor B lymphoblastic leukemia with IGH rearrangements."
2.	Residual Neoplasm 05/01/2014 - "In the case of long-term remission (≥5 years; n = 8), peripheral blood was tested for minimal residual disease (MRD) by t(11; 14) polymerase chain reaction (PCR) and immunoglobulin heavy-chain (IGH) PCR at the last follow-up. " 06/01/2014 - "In this study, we compared immunoglobulin heavy-chain-gene-based minimal residual disease (MRD) detection by real-time quantitative PCR (RQ-PCR) and next-generation sequencing (NGS) to assess whether NGS could overcome some limitations of RQ-PCR and further increase sensitivity, specificity, accuracy and reproducibility. " 04/01/2013 - "In this study we aimed to assess the value of real-time polymerase chain reaction (RT-PCR) for detecting the immunoglobulin heavy chain (IgH) gene rearrangement using allele-specific molecular beacons as fluorescence probes to quantify minimal residual disease (MRD) and also to correlate post-treatment flow cytometric detection of plasma cells' (PCs) expression of CD19, CD38, CD45, CD56 and CD138 in MM. After diagnosis of 17 MM patients, the CDR1, CDR2 and CDR3 regions of the IgH gene were analysed and sequenced to identify IgH's clonal nature. " 06/01/2011 - "Furthermore, progress in the identification of minimal residual disease (MRD) using consensus primer or patient specific polymerase chain reaction for the immunoglobulin heavy chain variable region gene (IGHV), as well as multiparameter flow cytometry, allows for the detection and eradication of MRD. " 06/01/2006 - "Minimal residual tumor clone identical with the primary lesion was detected using the polymerase chain reaction (PCR) clonality assay for immunoglobulin heavy chain gene (IgH) rearrangement. "
3.	Lymphoma (Lymphomas) 05/01/2009 - "The authors investigate the efficacy of using the cytokine levels and clonal heavy-chain immunoglobulin (IgH) gene rearrangements in the vitreous as adjunctive tools to diagnose intraocular lymphoma (IOL). " 04/25/2010 - "In this study, multiplex PCR studies for immunoglobulin heavy-chain or T-cell receptor gene rearrangements were useful for demonstrating clonality, and FISH studies were able to detect translocations or gene rearrangements that allowed for the subclassification of B-cell non-Hodgkin lymphomas." 12/01/2006 - "Molecular genetic studies of immunoglobulin heavy chain (IgH) gene rearrangement by polymerase chain reaction (PCR) showed clonal bands in 6 of 12 lymphomas, 1 of 3 RLH (polyclonal by immunophenotyping) and 1 ALH. " 03/01/2005 - "Molecular genetic studies showed that these 2 lymphomas had immunoglobulin heavy-chain gene rearrangements that were of identical size, suggesting that they were derived from the same clone. " 11/01/2003 - "Immunoglobulin heavy chain gene and T-cell receptor gene rearrangement studies demonstrated a germline pattern, confirming the putative NK (natural killer cell), non-B and non-T lineage of the lymphoma cells. "
4.	B-Cell Lymphoma (Lymphoma, B Cell) 05/01/2003 - "We investigated whether the determination of clonality by polymerase chain reaction (PCR) analysis of immunoglobulin heavy chain (IgH) gene rearrangements could be helpful in the evaluation of B-cell lymphoma (BCL) involvement of bone marrow (BM) biopsy specimens. " 10/01/2014 - "We performed FCI on 73 skin specimens from 67 patients clinically suspected of having a cutaneous B-cell lymphoma (CBCL) and compared the results with those obtained from immunoglobulin heavy chain (IGH) gene molecular studies (58 cases, primarily by polymerase chain reaction) and either immunohistochemistry (IHC) or in situ hybridization to evaluate for light chain restriction (22 and 2 cases, respectively). " 11/01/2013 - "Thus, the aim of this study was to analyze immunoglobulin heavy chain (IgH) gene rearrangement in a series of oral B cell lymphomas to investigate the sensitivity of seminested polymerase chain reaction (snPCR). " 10/01/2002 - "Here we describe the first case of CD5+ T-cell/histiocyte-rich large B-cell lymphoma that is well documented by histomorphology, immunohistochemistry, flow cytometry immunophenotyping and sorting, and immunoglobulin heavy-chain gene rearrangement study by polymerase chain reaction. " 01/01/2002 - "Immunohistopathologic examination and immunoglobulin heavy chain gene rearrangement studies led to a diagnosis of B-cell lymphoma. "
5.	Neoplasms (Cancer) 09/01/1992 - "Improved PCR method for detecting monoclonal immunoglobulin heavy chain rearrangement in B cell neoplasms." 12/01/2008 - "It was concluded from this study that RP215 reacts specifically with carbohydrate-associated epitope(s) of immunoglobulin heavy chains expressed by various human cancer cells." 11/01/1998 - "Immunoglobulin heavy chain (IgH) gene rearrangement and murine leukemia virus (MuLV) proviral integration patterns were used to study the clonal identities of the sequential tumor pairs in 11 informative mice by Southern blot hybridization. " 01/15/1986 - "Recent studies indicate that the selective advantage conferred by the 14q+ chromosome in B cell neoplasms appears to result from an oncogene being brought adjacent to a rearranged and transcriptionally active immunoglobulin heavy chain locus. " 11/01/2015 - "Chromosome translocations involving the immunoglobulin heavy chain (IGH) gene locus at chromosome region 14q32 are often observed in B-cell lymphoid neoplasms. "

Related Drugs and Biologics

1.	Complementarity Determining Regions (Complementarity Determining Region)
2.	DNA (Deoxyribonucleic Acid)
3.	gamma-delta T-Cell Antigen Receptors (T-Cell Receptor delta-Chain)
4.	Oligonucleotides
5.	Recombinant DNA (Recombinant DNA Research)
6.	T-Cell Antigen Receptors (T-Cell Receptor)
7.	Paraffin
8.	Carbon Monoxide
9.	Immunoglobulins (Immunoglobulin)
10.	alpha-beta T-Cell Antigen Receptors (T-Cell Receptor alpha-Chain)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Stem Cell Transplantation
3.	Transplants (Transplant)
4.	Aftercare (After-Treatment)
5.	Vitrectomy