Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)

The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.

Also Known As:

Immunoglobulin Heavy Chain; Heavy Chain, Immunoglobulin; Heavy-Chain Immunoglobulins; Ig Heavy Chains; Immunoglobulin Heavy Chain Subgroup VH-I; Immunoglobulin Heavy Chain Subgroup VH-III; Heavy Chain Immunoglobulins; Heavy Chains, Ig; Heavy Chains, Immunoglobulin; Immunoglobulin Heavy Chain Subgroup VH I; Immunoglobulin Heavy Chain Subgroup VH III; Immunoglobulins, Heavy Chain; Immunoglobulins, Heavy-Chain

Networked: 1667 relevant articles (23 outcomes, 112 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Immunoglobulin Subunits: 40
        Immunoglobulin Heavy Chains: 1667
        Immunoglobulin mu-Chains: 26
        Immunoglobulin alpha-Chains: 5
        Immunoglobulin gamma-Chains: 4
        Immunoglobulin epsilon-Chains: 2
        ALZ 0081
        human HS1,2-A enhancer protein
        human IGHV4-34 protein
        Immunoglobulin delta-Chains
        monoclonal antibody B23 heavy chain
        zebrafish immunoglobulin zeta
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Immunoglobulin Subunits: 40
        Immunoglobulin Heavy Chains: 1667
        Immunoglobulin mu-Chains: 26
        Immunoglobulin alpha-Chains: 5
        Immunoglobulin gamma-Chains: 4
        Immunoglobulin epsilon-Chains: 2
        ALZ 0081
        human HS1,2-A enhancer protein
        human IGHV4-34 protein
        Immunoglobulin delta-Chains
        monoclonal antibody B23 heavy chain
        zebrafish immunoglobulin zeta
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Immunoglobulin Subunits: 40
        Immunoglobulin Heavy Chains: 1667
        Immunoglobulin mu-Chains: 26
        Immunoglobulin alpha-Chains: 5
        Immunoglobulin gamma-Chains: 4
        Immunoglobulin epsilon-Chains: 2
        ALZ 0081
        human HS1,2-A enhancer protein
        human IGHV4-34 protein
        Immunoglobulin delta-Chains
        monoclonal antibody B23 heavy chain
        zebrafish immunoglobulin zeta

Experts

1.	Yoshino, Tadashi: 12 articles (09/2021 - 09/2004)
2.	Nakamura, Naoya: 12 articles (09/2018 - 06/2002)
3.	Keating, Michael J: 12 articles (01/2018 - 06/2003)
4.	Medeiros, L Jeffrey: 12 articles (04/2013 - 04/2002)
5.	Neri, Antonino: 10 articles (01/2020 - 02/2005)
6.	Xu, Wei: 10 articles (01/2020 - 07/2009)
7.	Fan, Lei: 9 articles (01/2020 - 07/2009)
8.	Gribben, John G: 9 articles (01/2015 - 07/2002)
9.	Wierda, William G: 9 articles (08/2014 - 06/2003)
10.	Gattei, Valter: 8 articles (01/2022 - 09/2004)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/01/1993 - "The PCR was used to detect monoclonal rearrangements of the immunoglobulin heavy chain and/or T-cell receptor gamma chain genes in archival marrow specimens from 185 children with acute lymphoblastic leukemia who achieved remission during two consecutive Australasian trials of treatment. " 11/01/2001 - "Absence of somatic hypermutation of immunoglobulin heavy chain variable region genes in precursor B-lymphoblastic lymphoma: a study of four cases in childhood and adolescence." 05/01/1989 - "Comparison studies of immunoglobulin heavy-chain gene rearrangements and also delta Mo + SV M-MuLV proviral integration sites confirmed that the macrophage cell line was derived from the original B-lymphoblastic lymphoma. " 11/06/2023 - "Childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) can be traced back to birth using leukemic clone-specific immunoglobulin heavy chain (IGH) rearrangements, implying prenatal origin of this disease. " 11/06/2023 - "Presence of leukemic clone-specific immunoglobulin heavy chain rearrangements in neonatal blood spots of children with B-cell precursor acute lymphoblastic leukemia."
2.	Residual Neoplasm 05/01/2014 - "In the case of long-term remission (≥5 years; n = 8), peripheral blood was tested for minimal residual disease (MRD) by t(11; 14) polymerase chain reaction (PCR) and immunoglobulin heavy-chain (IGH) PCR at the last follow-up. " 01/01/2020 - "Test trial of spike-in immunoglobulin heavy-chain (IGH) controls for next generation sequencing quantification of minimal residual disease in acute lymphoblastic leukaemia." 06/01/2014 - "In this study, we compared immunoglobulin heavy-chain-gene-based minimal residual disease (MRD) detection by real-time quantitative PCR (RQ-PCR) and next-generation sequencing (NGS) to assess whether NGS could overcome some limitations of RQ-PCR and further increase sensitivity, specificity, accuracy and reproducibility. " 04/01/2013 - "In this study we aimed to assess the value of real-time polymerase chain reaction (RT-PCR) for detecting the immunoglobulin heavy chain (IgH) gene rearrangement using allele-specific molecular beacons as fluorescence probes to quantify minimal residual disease (MRD) and also to correlate post-treatment flow cytometric detection of plasma cells' (PCs) expression of CD19, CD38, CD45, CD56 and CD138 in MM. After diagnosis of 17 MM patients, the CDR1, CDR2 and CDR3 regions of the IgH gene were analysed and sequenced to identify IgH's clonal nature. " 04/01/2021 - "This review of laboratory testing in CLL focuses on emerging technologies for prognostication including single nucleotide polymorphism microarray for karyotypic analysis, targeted next generation sequencing analysis of the immunoglobulin heavy chain variable region gene as well as genes recurrently mutated in the disease such as TP53, and detection of minimal residual disease."
3.	Neoplasms (Cancer) 07/01/1997 - "In the present report we have explored the recently described improved strategy for assessment of clonality of rearranged immunoglobulin heavy chain (IgH) genes in more detail in a series of 101 B cell malignancies and 50 polyclonal controls. " 03/01/2000 - "Molecular detection of the immunoglobulin heavy chain gene third complementary determining region rearrangement is helpful in the diagnosis of the malignancy. " 09/01/1992 - "Improved PCR method for detecting monoclonal immunoglobulin heavy chain rearrangement in B cell neoplasms." 11/01/1998 - "Immunoglobulin heavy chain (IgH) gene rearrangement and murine leukemia virus (MuLV) proviral integration patterns were used to study the clonal identities of the sequential tumor pairs in 11 informative mice by Southern blot hybridization. " 12/01/1994 - "Recent polymerase chain reaction (PCR)-based studies focused on the detection of immunoglobulin heavy chain gene (IgH) rearrangements have suggested that clonal populations may be amplified more easily from certain categories of B-cell neoplasia than others and that primer makeup can be a critical factor in successful amplification. "
4.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 10/06/2015 - "The immunoglobulin heavy-chain variable region (IGHV) mutational status is a strong determinant of remission duration in chronic lymphocytic leukemia (CLL). " 01/01/2017 - "The immunoglobulin heavy-chain variable region gene (IgHV) mutational status is considered the gold standard of prognostication in chronic lymphocytic leukemia (CLL) and is currently determined by Sanger sequencing that allows the analysis of the major clone. " 01/01/2020 - "Patients with chronic lymphocytic leukemia and unmutated immunoglobulin heavy-chain variable region gene (IGHV) have inferior survival from time of treatment in clinical studies. " 12/28/2022 - "Here, we report a case of RS isolated in the CNS that was confirmed to be clonally related to chronic lymphocytic leukemia (CLL) by immunoglobulin heavy chain gene analysis. " 11/08/2022 - "Objective: To investigate the mutational features of the immunoglobulin heavy chain variable region (IgHV) gene in patients with chronic lymphocytic leukemia (CLL) using immunophenotypic and molecular genetic methods. "
5.	B-Cell Lymphoma (Lymphoma, B Cell) 05/01/2003 - "We investigated whether the determination of clonality by polymerase chain reaction (PCR) analysis of immunoglobulin heavy chain (IgH) gene rearrangements could be helpful in the evaluation of B-cell lymphoma (BCL) involvement of bone marrow (BM) biopsy specimens. " 10/01/2014 - "We performed FCI on 73 skin specimens from 67 patients clinically suspected of having a cutaneous B-cell lymphoma (CBCL) and compared the results with those obtained from immunoglobulin heavy chain (IGH) gene molecular studies (58 cases, primarily by polymerase chain reaction) and either immunohistochemistry (IHC) or in situ hybridization to evaluate for light chain restriction (22 and 2 cases, respectively). " 11/01/2013 - "Thus, the aim of this study was to analyze immunoglobulin heavy chain (IgH) gene rearrangement in a series of oral B cell lymphomas to investigate the sensitivity of seminested polymerase chain reaction (snPCR). " 10/01/2002 - "Here we describe the first case of CD5+ T-cell/histiocyte-rich large B-cell lymphoma that is well documented by histomorphology, immunohistochemistry, flow cytometry immunophenotyping and sorting, and immunoglobulin heavy-chain gene rearrangement study by polymerase chain reaction. " 01/01/2002 - "Immunohistopathologic examination and immunoglobulin heavy chain gene rearrangement studies led to a diagnosis of B-cell lymphoma. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	T-Cell Antigen Receptors (T-Cell Receptor)
3.	Complementarity Determining Regions (Complementarity Determining Region)
4.	Messenger RNA (mRNA)
5.	RNA (Ribonucleic Acid)
6.	gamma-delta T-Cell Antigen Receptors (T-Cell Receptor delta-Chain)
7.	Monoclonal Antibodies
8.	Oligonucleotides
9.	Cytokines
10.	Recombinant DNA (Recombinant DNA Research)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Stem Cell Transplantation
3.	Induction Chemotherapy
4.	Therapeutics
5.	Aftercare (After-Treatment)