Immunoglobulin gamma-Chains (gamma-Chain, Immunoglobulin)

Heavy chains of IMMUNOGLOBULIN G having a molecular weight of approximately 51 kDa. They contain about 450 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region. The gamma heavy chain subclasses (for example, gamma 1, gamma 2a, and gamma 2b) of the IMMUNOGLOBULIN G isotype subclasses (IgG1, IgG2A, and IgG2B) resemble each other more closely than the heavy chains of the other IMMUNOGLOBULIN ISOTYPES.

Also Known As:

gamma-Chain, Immunoglobulin; Immunoglobulin gamma-Chain; gamma Immunoglobulin Heavy Chain; gamma Immunoglobulin Heavy Chains; gamma-1-Immunoglobulin Heavy Chain; gamma-2a-Immunoglobulin Heavy Chain; gamma-2b-Immunoglobulin Heavy Chain; gamma-Chain Immunoglobulins; Heavy Chain, gamma-1-Immunoglobulin; Heavy Chain, gamma-2a-Immunoglobulin; Heavy Chain, gamma-2b-Immunoglobulin; Immunoglobulin gamma Chain; Immunoglobulin gamma Chains; Immunoglobulins, gamma Chain; gamma 1 Immunoglobulin Heavy Chain; gamma 2a Immunoglobulin Heavy Chain; gamma 2b Immunoglobulin Heavy Chain; gamma Chain Immunoglobulins; gamma-Chains, Immunoglobulin; Immunoglobulins, gamma-Chain

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Immunoglobulin Isotypes: 1085
        Immunoglobulin G: 58863
        Immunoglobulin gamma-Chains: 4
        Immunoglobulin Gm Allotypes: 110
        Ro 45-2081: 23
        human CHA heavy chain disease protein
        human FOR heavy chain disease protein
        human heavy chain disease proteins
        human IgC3kappa Jir protein
        human RIV immunoglobulin variant protein
        human Wis heavy-chain disease protein
        immunorphin
        recombinant CD4-IgG1 hinge fusion protein
        Immunoglobulin Subunits: 40
        Immunoglobulin Heavy Chains: 1667
        Immunoglobulin gamma-Chains: 4
        Immunoglobulin Gm Allotypes: 110
        Ro 45-2081: 23
        human CHA heavy chain disease protein
        human FOR heavy chain disease protein
        human heavy chain disease proteins
        human IgC3kappa Jir protein
        human RIV immunoglobulin variant protein
        human Wis heavy-chain disease protein
        immunorphin
        recombinant CD4-IgG1 hinge fusion protein
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Immunoglobulin Isotypes: 1085
        Immunoglobulin G: 58863
        Immunoglobulin gamma-Chains: 4
        Immunoglobulin Gm Allotypes: 110
        Ro 45-2081: 23
        human CHA heavy chain disease protein
        human FOR heavy chain disease protein
        human heavy chain disease proteins
        human IgC3kappa Jir protein
        human RIV immunoglobulin variant protein
        human Wis heavy-chain disease protein
        immunorphin
        recombinant CD4-IgG1 hinge fusion protein
        Immunoglobulin Subunits: 40
        Immunoglobulin Heavy Chains: 1667
        Immunoglobulin gamma-Chains: 4
        Immunoglobulin Gm Allotypes: 110
        Ro 45-2081: 23
        human CHA heavy chain disease protein
        human FOR heavy chain disease protein
        human heavy chain disease proteins
        human IgC3kappa Jir protein
        human RIV immunoglobulin variant protein
        human Wis heavy-chain disease protein
        immunorphin
        recombinant CD4-IgG1 hinge fusion protein
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Immunoglobulin Isotypes: 1085
        Immunoglobulin G: 58863
        Immunoglobulin gamma-Chains: 4
        Immunoglobulin Gm Allotypes: 110
        Ro 45-2081: 23
        human CHA heavy chain disease protein
        human FOR heavy chain disease protein
        human heavy chain disease proteins
        human IgC3kappa Jir protein
        human RIV immunoglobulin variant protein
        human Wis heavy-chain disease protein
        immunorphin
        recombinant CD4-IgG1 hinge fusion protein
        Immunoglobulin Subunits: 40
        Immunoglobulin Heavy Chains: 1667
        Immunoglobulin gamma-Chains: 4
        Immunoglobulin Gm Allotypes: 110
        Ro 45-2081: 23
        human CHA heavy chain disease protein
        human FOR heavy chain disease protein
        human heavy chain disease proteins
        human IgC3kappa Jir protein
        human RIV immunoglobulin variant protein
        human Wis heavy-chain disease protein
        immunorphin
        recombinant CD4-IgG1 hinge fusion protein

Experts

1.	Gondek, Michał: 1 article (01/2020)
2.	Herosimczyk, Agnieszka: 1 article (01/2020)
3.	Knysz, Przemysław: 1 article (01/2020)
4.	Lepczyński, Adam: 1 article (01/2020)
5.	Ożgo, Małgorzata: 1 article (01/2020)
6.	Szkucik, Krzysztof: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 06/01/1995 - "The breakpoint of 14q32 translocations found in B-cell malignancies was delineated specifically in both metaphase spreads and interphase nuclei by double-color fluorescence in situ hybridization (FISH) using bacteriophage clones containing the human immunoglobulin gamma chain gene locus (Ig gamma) and a cosmid clone, CY24-68, containing VH segments. " 01/01/1995 - "Two of the biopsies from dogs with cutaneous plasmacotyoma were shown to express immunoglobulin alpha chain (one with lambda chain) and two neoplasms were positive for immunoglobulin gamma chain (both with lambda chain). "
2.	Plasmacytoma 12/10/1983 - "c-myc Gene rearrangements involving gamma immunoglobulin heavy chain gene switch regions in murine plasmacytomas."
3.	Infections 01/11/2020 - "Depending on the Trichinella species triggering the infection and the time point of serum collection, they were IgM heavy-chain constant region, antithrombin III-precursor, immunoglobulin gamma-chain, clusterin, homeobox protein Mohawk, apolipoprotein E precursor, serum amyloid P-component precursor, Ig lambda chains, complement C3 isoform X1, and apolipoprotein A-I. Our results demonstrate that various Trichinella species and different phases of the invasion produce a distinct, characteristic proteomic pattern in the serum of experimentally infected pigs."

Related Drugs and Biologics

1.	Clusterin
2.	Protein Isoforms (Isoforms)
3.	Homeodomain Proteins (Proteins, Homeobox)
4.	Apolipoprotein A-I (Apolipoprotein A1)
5.	Immunoglobulin lambda-Chains
6.	Immunoglobulin alpha-Chains
7.	Immunoglobulin M (IgM)
8.	Complement C3 (C3 Complement)
9.	Apolipoproteins
10.	Antithrombin III